{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:12:22Z","timestamp":1791043942973,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Pulmonary vein isolation (PVI) represents the gold standard in the treatment of atrial fibrillation (AF) and the use of single-shot techniques, such as cryoballoon ablation (CBA) and pulsed field ablation (PFA) using a pentaspline catheter, has gained prominence. Recent studies hypothesize that PFA might be superior to CBA, although procedural efficacy and safety data are inconsistent. A meta-analysis was conducted to compare both energy sources for the treatment of AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A structured systematic database search and meta-analysis were performed on studies investigating outcomes, periprocedural complications, and\/or procedural parameters of AF patients treated by either CBA or PFA. Eleven studies reporting data from 3805 patients were included. Pulmonary vein isolation by PFA was associated with a significantly lower recurrence of atrial fibrillation\/atrial tachycardia [odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.54\u20130.98, I2 = 20%] and fewer periprocedural complications (OR = 0.62, 95% CI = 0.40\u20130.96, I2 = 6%) compared to CBA. The lower complication rate following PFA was mainly driven by fewer phrenic nerve injuries (OR = 0.19, 95% CI = 0.08\u20130.43, I2 = 0%). However, there were more cases of cardiac tamponades after PFA (OR = 2.56, 95% CI = 1.01\u20136.49, I2 = 0%). Additionally, using PFA for PVI was associated with shorter total procedure times [mean difference (MD) = \u22129.68, 95% CI = \u221214.92 to \u22124.43\u2005min, I2 = 92%] and lower radiation exposure (MD = \u2212148.07, 95% CI = \u2212276.50 to \u221219.64\u2005\u00b5Gy\u00b7mI2 = 7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that PFA for PVI, compared to CBA, enables shorter procedure times with lower arrhythmia recurrence and a reduced risk of periprocedural complications. Randomized controlled trials need to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeae044","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T08:56:18Z","timestamp":1716972978000},"source":"Crossref","is-referenced-by-count":25,"title":["Efficacy and safety of pulsed field ablation compared to cryoballoon ablation in the treatment of atrial fibrillation: a meta-analysis"],"prefix":"10.1093","volume":"4","author":[{"given":"Isabel","family":"Rudolph","sequence":"first","affiliation":[{"name":"School of Medicine and Health, Department of Clinical Medicine\u2014Clinical Department for Cardiology, University Medical Centre, Technical University of Munich , Ismaninger Stra\u00dfe 22, 81675 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Mastella","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Department of Clinical 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