{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:03:41Z","timestamp":1788239021395,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CS\/15\/7\/31679"],"award-info":[{"award-number":["CS\/15\/7\/31679"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Women and older patients are underrepresented in randomized controlled trials (RCTs) investigating treatment strategies following acute coronary syndrome. This study aims to evaluate the benefit of invasive vs. conservative strategy of older women with non-ST-elevation acute coronary syndrome (NSTEACS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This analysis from an individual patient data meta-analysis included six RCTs comparing an invasive management with a conservative management in older NSTEACS patients. The primary endpoint was the composite of all-cause mortality or myocardial infarction (MI). Secondary endpoints included all-cause mortality, cardiovascular death, MI, urgent revascularization, and stroke. Follow-up time was censored at 1 year. In total, 717 women [median age 84.0 (interquartile range 81.0\u201387.0) years] were included. The primary endpoint occurred in 21.0% in the invasive strategy vs. 27.8% in the conservative strategy [hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.52\u20131.13, P = 0.160 using random effect] at 1-year follow-up. The invasive management was associated with reduced risk of MI (HR 0.49, 95% CI 0.32\u20130.73, P &amp;lt; 0.001) and urgent revascularization (HR 0.44, 95% CI 0.20\u20130.98, P = 0.045). No significant differences were identified in the risk of all-cause mortality, cardiovascular death, and stroke. Among males, there was no significant association between the treatment strategy and primary or secondary endpoints.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An invasive strategy compared with a conservative strategy did not reduce the composite outcome of all-cause mortality or MI in older NSTEACS women at 1-year follow-up. An invasive strategy reduced the individual risk of MI and urgent revascularization. Our results support the beneficial role of the invasive strategy in older NSTEACS women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>This meta-analysis is registered with PROSPERO (CRD42023379819).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeae093","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T22:56:13Z","timestamp":1729896973000},"source":"Crossref","is-referenced-by-count":5,"title":["Older women with non-ST-elevation acute coronary syndrome undergoing invasive or conservative management: an individual patient data meta-analysis"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-1032","authenticated-orcid":false,"given":"Francesca","family":"Rubino","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 4th Floor William Leech Building, Newcastle upon Tyne NE2 4HH ,","place":["UK"]},{"name":"Department of Cardiology, HartCentrum, Ziekenhuis aan de Stroom (ZAS) Middelheim, Lindendreef 1, 2020 \u00a0 Antwerp ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-0703","authenticated-orcid":false,"given":"Graziella","family":"Pompei","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 4th Floor William Leech Building, Newcastle upon Tyne NE2 4HH ,","place":["UK"]},{"name":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro 8, 44124 \u00a0 Cona, FE ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-3594","authenticated-orcid":false,"given":"Gregory B","family":"Mills","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 4th Floor William Leech Building, Newcastle upon Tyne NE2 4HH ,","place":["UK"]},{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust , Freeman Rd, High Heaton, Newcastle upon Tyne, NE7 7DN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos P","family":"Kotanidis","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 4th Floor William Leech Building, Newcastle upon Tyne NE2 4HH ,","place":["UK"]},{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust , Freeman Rd, High Heaton, Newcastle upon Tyne, NE7 7DN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-7402","authenticated-orcid":false,"given":"Claudio","family":"Laudani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliero Universitaria Policlinico \u2018G. Rodolico-San Marco\u2019, University of Catania , Via S. Sofia 78, 95123 Catania ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-6481","authenticated-orcid":false,"given":"Bj\u00f8rn","family":"Bendz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital , Postboks 4950 Nydalen, OUS HF Rikshospitalet, 0424 Oslo ,","place":["Norway"]},{"name":"Division of Medicine, Institute of Clinical Medicine, University of Oslo , P.O box 1171 Blindern, 0318 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlend S","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital , Postboks 4950 Nydalen, OUS HF Rikshospitalet, 0424 Oslo ,","place":["Norway"]},{"name":"Division of Medicine, Institute of Clinical Medicine, University of Oslo , P.O box 1171 Blindern, 0318 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-1436","authenticated-orcid":false,"given":"David","family":"Hildick-Smith","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, University Hospitals Sussex NHS Foundation Trust , Lyndhurst Road, Worthing, BN11 2DH, West Sussex ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Hirlekar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University , Gothenburg, SU Sahlgrenska, 41345 Gothenburg ,","place":["Sweden"]},{"name":"Department of Cardiology, Sahlgrenska University Hospital , Bl\u00e5 Str\u00e5ket 5, 413 45 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-8857","authenticated-orcid":false,"given":"Nuccia","family":"Morici","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, IRCCS Fondazione Don Carlo Gnocchi , Via Carlo Girola 30, 20162 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung","family":"Myat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medpace, Vitners' Place 68 , Upper Thames Street, London EC4V 3BJ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Tegn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital , Postboks 4950 Nydalen, OUS HF Rikshospitalet, 0424 Oslo ,","place":["Norway"]},{"name":"Division of Medicine, Institute of Clinical Medicine, University of Oslo , P.O box 1171 Blindern, 0318 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sanchis For\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario, INCLIVA, Universitat de Valencia, CIBER-CV , Avda Blasco Ib\u00e1\u00f1ez 17, 46010, Valencia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Savonitto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinica San Martino, Via Paradiso angolo Via Selvetta, 23864 , Malgrate ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"De Servi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Pavia , Viale Golgi 19, 27100 Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-6971","authenticated-orcid":false,"given":"Vijay","family":"Kunadian","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 4th Floor William Leech Building, Newcastle upon Tyne NE2 4HH ,","place":["UK"]},{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust , Freeman Rd, High Heaton, Newcastle upon Tyne, NE7 7DN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"2024122015554841700_oeae093-B1","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The Lancet women and cardiovascular disease commission: reducing the global burden by 2030","volume":"397","author":"Vogel","year":"2021","journal-title":"Lancet"},{"key":"2024122015554841700_oeae093-B2","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.amjmed.2016.05.031","article-title":"Age at menopause and extent of coronary artery disease among postmenopausal women with acute coronary syndromes","volume":"129","author":"Savonitto","year":"2016","journal-title":"Am J Med"},{"key":"2024122015554841700_oeae093-B3","first-page":"heartjnl-2024-324625","article-title":"Advancing the access to cardiovascular diagnosis and treatment among women with cardiovascular disease: a joint British Cardiovascular Societies\u2019 consensus document","author":"Tayal","year":"2024","journal-title":"Heart"},{"key":"2024122015554841700_oeae093-B4","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"key":"2024122015554841700_oeae093-B5","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/ehjqcco\/qcad007","article-title":"Representativeness in randomised clinical trials supporting acute coronary syndrome guidelines","volume":"9","author":"Mas-Llado","year":"2023","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"2024122015554841700_oeae093-B6","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1093\/eurheartj\/ehad452","article-title":"Raising awareness about cardiovascular disease in women","volume":"44","author":"Lawless","year":"2023","journal-title":"Eur Heart J"},{"key":"2024122015554841700_oeae093-B7","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1161\/CIR.0000000000001112","article-title":"Management of acute coronary syndrome in the older adult population: a scientific statement from the American Heart Association","volume":"147","author":"Damluji","year":"2023","journal-title":"Circulation"},{"key":"2024122015554841700_oeae093-B8","doi-asserted-by":"crossref","first-page":"e007123","DOI":"10.1161\/JAHA.117.007123","article-title":"Sex differences in treatments, relative survival, and excess mortality following acute myocardial infarction: national cohort study using the SWEDEHEART registry","volume":"6","author":"Alabas","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2024122015554841700_oeae093-B9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.2012.199","article-title":"Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality","volume":"307","author":"Canto","year":"2012","journal-title":"JAMA"},{"key":"2024122015554841700_oeae093-B10","doi-asserted-by":"crossref","first-page":"e001995","DOI":"10.1161\/JAHA.115.001995","article-title":"Trends in gender differences in cardiac care and outcome after acute myocardial infarction in western Sweden: a report from the Swedish Web system for enhancement of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART)","volume":"4","author":"Redfors","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2024122015554841700_oeae093-B11","doi-asserted-by":"crossref","first-page":"oead033","DOI":"10.1093\/ehjopen\/oead033","article-title":"Sex differences in treatment and outcomes amongst myocardial infarction patients presenting with and without obstructive coronary arteries: a prospective multicentre study","volume":"3","author":"Lawless","year":"2023","journal-title":"Eur Heart J Open"},{"key":"2024122015554841700_oeae093-B12","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jcin.2014.12.240","article-title":"Sex-related outcomes in elderly patients presenting with non-ST-segment elevation acute coronary syndrome: insights from the Italian elderly ACS study","volume":"8","author":"De Carlo","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"key":"2024122015554841700_oeae093-B13","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.amjmed.2021.03.025","article-title":"Association of sex with outcome in elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention","volume":"134","author":"De Rosa","year":"2021","journal-title":"Am J Med"},{"key":"2024122015554841700_oeae093-B14","doi-asserted-by":"crossref","first-page":"e022883","DOI":"10.1161\/JAHA.121.022883","article-title":"Sex differences in cardiovascular outcomes of older adults after myocardial infarction","volume":"10","author":"Kerola","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2024122015554841700_oeae093-B15","first-page":"101118","article-title":"Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: an ICON-1 sub-study","volume":"42","author":"Ratcovich","year":"2022","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2024122015554841700_oeae093-B16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.amjcard.2016.09.052","article-title":"Gender differences in outcomes and predictors of all-cause mortality after percutaneous coronary intervention (data from United Kingdom and Sweden)","volume":"119","author":"Kunadian","year":"2017","journal-title":"Am J Cardiol"},{"key":"2024122015554841700_oeae093-B17","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/eurheartj\/ehae151","article-title":"Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis","volume":"45","author":"Kotanidis","year":"2024","journal-title":"Eur Heart J"},{"key":"2024122015554841700_oeae093-B18","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jcin.2012.06.008","article-title":"Early aggressive versus initially conservative treatment in elderly patients with non-ST-segment elevation acute coronary syndrome: a randomized controlled trial","volume":"5","author":"Savonitto","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"2024122015554841700_oeae093-B19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejim.2016.07.003","article-title":"Randomized comparison between the invasive and conservative strategies in comorbid elderly patients with non-ST elevation myocardial infarction","volume":"35","author":"Sanchis","year":"2016","journal-title":"Eur J Intern Med"},{"key":"2024122015554841700_oeae093-B20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/jamainternmed.2023.0047","article-title":"Effect of routine invasive vs conservative strategy in older adults with frailty and non-ST-segment elevation acute myocardial infarction: a randomized clinical trial","volume":"183","author":"Sanchis","year":"2023","journal-title":"JAMA Intern Med"},{"key":"2024122015554841700_oeae093-B21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4244\/EIJ-D-20-00975","article-title":"Revascularisation or medical therapy in elderly patients with acute anginal syndromes: the RINCAL randomised trial","volume":"17","author":"de Belder","year":"2021","journal-title":"EuroIntervention"},{"key":"2024122015554841700_oeae093-B22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14017431.2020.1781243","article-title":"Percutaneous coronary intervention in the very elderly with NSTE-ACS: the randomized 80+ study","volume":"54","author":"Hirlekar","year":"2020","journal-title":"Scand Cardiovasc J"},{"key":"2024122015554841700_oeae093-B23","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(15)01166-6","article-title":"Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial","volume":"387","author":"Tegn","year":"2016","journal-title":"Lancet"},{"key":"2024122015554841700_oeae093-B24","doi-asserted-by":"crossref","first-page":"e001256","DOI":"10.1136\/openhrt-2020-001256","article-title":"Patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris randomised to an invasive versus conservative strategy: angiographic and procedural results from the After Eighty study","volume":"7","author":"Tegn","year":"2020","journal-title":"Open Heart"},{"key":"2024122015554841700_oeae093-B25","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.jacc.2023.09.809","article-title":"Long-term outcomes of invasive vs conservative strategies for older patients with non-ST-segment elevation acute coronary syndromes","volume":"82","author":"Berg","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2024122015554841700_oeae093-B26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0735-1097(01)01308-0","article-title":"Is early invasive treatment of unstable coronary artery disease equally effective for both women and men? FRISC II study group investigators","volume":"38","author":"Lagerqvist","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2024122015554841700_oeae093-B27","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.ehj.2004.07.032","article-title":"Do men benefit more than women from an interventional strategy in patients with unstable angina or non-ST-elevation myocardial infarction? The impact of gender in the RITA 3 trial","volume":"25","author":"Clayton","year":"2004","journal-title":"Eur Heart J"},{"key":"2024122015554841700_oeae093-B28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/heartjnl-2011-300453","article-title":"Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials","volume":"98","author":"Damman","year":"2012","journal-title":"Heart"},{"key":"2024122015554841700_oeae093-B29","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2407791","article-title":"Invasive treatment strategy for older patients with myocardial infarction","author":"Kunadian","year":"2024","journal-title":"N Engl J Med"},{"key":"2024122015554841700_oeae093-B30","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.amjmed.2014.12.032","article-title":"Cumulative incidence of death and rehospitalization among the elderly in the first year after NSTEMI","volume":"128","author":"Lopes","year":"2015","journal-title":"Am J Med"},{"key":"2024122015554841700_oeae093-B31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.recesp.2020.06.025","article-title":"Comorbidity burden and revascularization benefit in elderly patients with acute coronary syndrome","volume":"74","author":"Sanchis","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2024122015554841700_oeae093-B32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.300.1.71","article-title":"Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis","volume":"300","author":"O\u2019Donoghue","year":"2008","journal-title":"JAMA"},{"key":"2024122015554841700_oeae093-B33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0002-9149(01)01679-4","article-title":"Effect of gender on the outcomes of contemporary percutaneous coronary intervention","volume":"88","author":"Peterson","year":"2001","journal-title":"Am J Cardiol"},{"key":"2024122015554841700_oeae093-B34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ahj.2009.12.040","article-title":"Gender differences in adverse outcomes after contemporary percutaneous coronary intervention: an analysis from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) percutaneous coronary intervention registry","volume":"159","author":"Duvernoy","year":"2010","journal-title":"Am Heart J"},{"key":"2024122015554841700_oeae093-B35","doi-asserted-by":"crossref","first-page":"e061830","DOI":"10.1136\/bmjopen-2022-061830","article-title":"Impact of multimorbidity on long-term outcomes in older adults with non-ST elevation acute coronary syndrome in the north east of England: a multi-centre cohort study of patients undergoing invasive care","volume":"12","author":"Beska","year":"2022","journal-title":"BMJ Open"},{"key":"2024122015554841700_oeae093-B36","doi-asserted-by":"crossref","first-page":"oeac035","DOI":"10.1093\/ehjopen\/oeac035","article-title":"Five-year clinical outcomes in patients with frailty aged \u226575 years with non-ST elevation acute coronary syndrome undergoing invasive management","volume":"2","author":"Ratcovich","year":"2022","journal-title":"Eur Heart J Open"}],"container-title":["European Heart Journal Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjopen\/advance-article-pdf\/doi\/10.1093\/ehjopen\/oeae093\/60094483\/oeae093.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/4\/6\/oeae093\/61228422\/oeae093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/4\/6\/oeae093\/61228422\/oeae093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T15:56:13Z","timestamp":1734710173000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjopen\/article\/doi\/10.1093\/ehjopen\/oeae093\/7841958"}},"subtitle":[],"editor":[{"given":"Salvatore","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjopen\/oeae093","relation":{},"ISSN":["2752-4191"],"issn-type":[{"value":"2752-4191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,10,26]]},"article-number":"oeae093"}}