{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:22:36Z","timestamp":1784290956155,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIH\/NCI Cancer Center Support","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cardiac impairment in AL amyloidosis is the major determinant of survival. Treatment goals include reducing circulating light chains to improve organ function. Global longitudinal strain (GLS) is an independent predictor of survival and useful for assessing cardiac function before and after therapy. This study aimed to describe GLS change from baseline to one year post-treatment, identify factors associated with GLS improvement (GLS+), and evaluate its prognostic significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Ninety-seven patients with AL amyloidosis and cardiac stage II\/III disease who underwent echocardiogram and haematologic evaluation at baseline and one year were included. GLS+ was defined as a 2.0%-point increase. A cardiac or B-type natriuretic peptide (BNP+) response was defined as a 30% reduction from baseline. Overall survival was measured from baseline echocardiogram to death. Of 97 patients, 62% had Stage II, 29% Stage IIIa, and 9% Stage IIIb disease. Baseline median left ventricular ejection fraction, GLS, and septal thickness were 65%, \u221214.9%, and 1.3\u2005cm, respectively. GLS+ was observed in 36% of patients and BNP+ in 51%. Median overall survival was 113.4 months. The hazard ratio for survival was 0.42 in the GLS+ group and 0.46 in the BNP+ group, after adjusting for haematologic response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>GLS improvement post-treatment confers a significant survival benefit. This study supports GLS as an important marker for risk stratification and cardiac response.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeaf104","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T11:53:48Z","timestamp":1755258828000},"source":"Crossref","is-referenced-by-count":4,"title":["Improvement in global longitudinal strain following plasma cell-directed therapy is associated with long-term survival among patients with AL amyloidosis"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0444-7056","authenticated-orcid":false,"given":"Kristine H","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Stony Brook University Hospital , Stony Brook, NY 11794 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F","family":"Yu","sequence":"additional","affiliation":[{"name":"Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY 10065 ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY 10065 ,","place":["USA"]},{"name":"Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Dept of Biostatistics, Weill Cornell Medical College , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-5998","authenticated-orcid":false,"given":"Richard K","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington , Seattle, WA 98195 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew S","family":"Mauer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Lee","family":"Chuy","sequence":"additional","affiliation":[{"name":"Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-0154","authenticated-orcid":false,"given":"Daniel","family":"Lenihan","sequence":"additional","affiliation":[{"name":"St Francis Healthcare , Cape Girardeau, MO 63703 ,","place":["USA"]},{"name":"International Cardio-Oncology Society , Tampa, FL 33606 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Can","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northwell Health\u2014Southshore University Hospital , Bay Shore Island, NY 11706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol L","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY 10065 ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1716-1950","authenticated-orcid":false,"given":"Jennifer E","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY 10065 ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2025091920403808400_oeaf104-B1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1182\/blood-2016-11-751628","article-title":"Improved outcomes for newly diagnosed AL amyloidosis between 2000 and 2014: cracking the glass ceiling of early death","volume":"129","author":"Muchtar","year":"2017","journal-title":"Blood"},{"key":"2025091920403808400_oeaf104-B2","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1200\/JCO.2011.37.7614","article-title":"New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes","volume":"30","author":"Palladini","year":"2012","journal-title":"J Clin 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