{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:39:02Z","timestamp":1759538342000,"version":"build-2065373602"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Over recent decades, numerous measures have been implemented to improve treatment and timely intervention for ST-elevation myocardial infarction (STEMI). For deeper insights into the current state of care, this study investigates whether patient outcomes differ based on the timing of presentation (on-hours vs. off-hours) for primary percutaneous coronary intervention (PCI) for STEMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Data from STEMI PCIs performed from 2017 to October 2020, as registered within the Netherlands Heart Registration (NHR), were analysed. Off-hours presentation was defined as arrival at the catheterization laboratory (cath lab) on weekends, during working days between 17.00 and 08.00, or Monday between midnight and 08.00. Short-term outcomes included 30-day all-cause mortality and acute MI within 30 days. Long-term outcomes included all-cause mortality rates up till 5 years after PCI, target vessel revascularization within 1 year, and repeat revascularization with elective or non-STEMI PCI. The study included 19 090 STEMI patients from 17 centres, with 11 719 (61.4%) PCIs performed on-hours. No significant difference in 30-day mortality was observed between on-hours and off-hours patients (5.7% vs. 5.8%). On-hours patients had a longer time from symptom onset to cath lab arrival (\u22646\u2005h: 80.2% vs. 84.4%, P &amp;lt; 0.001) and were less likely to present with out-of-hospital cardiac arrest (7.6% vs. 9.5%, P &amp;lt; 0.001). No statistically significant differences in long-term outcomes were observed after adjusting for confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Outcomes after primary PCI for STEMI are comparable between on-hours and off-hours presentations. The quality of care appears to be independent of time of arrival at the cath lab.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeaf118","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T22:34:13Z","timestamp":1758321253000},"source":"Crossref","is-referenced-by-count":0,"title":["Netherlands Heart Registration-based multicentre retrospective cohort study on primary PCI for ST-elevation myocardial infarction: comparing patient relevant outcomes in on- vs. off-hour presentations"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8435-6474","authenticated-orcid":false,"given":"Lineke","family":"Derks","sequence":"first","affiliation":[{"name":"Netherlands Heart Registration , Moreelsepark 1, Utrecht 3511 EP ,","place":["The Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , PO Box 616, 6200 MD Maastricht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke J C","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Netherlands Heart Registration , Moreelsepark 1, Utrecht 3511 EP ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M F","family":"Claassens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tergooi MC , Postbus 10016, 1201 DA Hilversum ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Isala , Postbus 10400, 8000 GK Zwolle ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"van Veghel","sequence":"additional","affiliation":[{"name":"Netherlands Heart Registration , Moreelsepark 1, Utrecht 3511 EP ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krischan D","family":"Sjauw","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital , Postbus 2500, 3430 EM Nieuwegein ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Danse","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rijnstate , Postbus 9555, 6800 TA Arnhem ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0109-2792","authenticated-orcid":false,"given":"Karin","family":"Arkenbout","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tergooi MC , Postbus 10016, 1201 DA Hilversum ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Isala , Postbus 10400, 8000 GK Zwolle ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"2025100309121192700_oeaf118-B1","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/eurheartj\/ehn416","article-title":"Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology","volume":"29","author":"Van de Werf","year":"2008","journal-title":"Eur Heart J"},{"key":"2025100309121192700_oeaf118-B2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/jama.2010.1139","article-title":"System delay and mortality among patients with STEMI treated with primary percutaneous coronary 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with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"2025100309121192700_oeaf118-B6","first-page":"382","article-title":"Impact of admission hours on each stage of care and total reperfusion delays in patients with ST elevation myocardial infarction","volume":"11","author":"Haygert","year":"2021","journal-title":"Am J Cardiovasc Dis"},{"key":"2025100309121192700_oeaf118-B7","doi-asserted-by":"crossref","first-page":"E185","DOI":"10.25270\/jic\/22.00367","article-title":"Off-hours presentation, door-to-balloon time, and clinical outcomes in patients referred for primary percutaneous coronary intervention","volume":"35","author":"Rashid","year":"2023","journal-title":"J Invasive Cardiol"},{"key":"2025100309121192700_oeaf118-B8","doi-asserted-by":"crossref","first-page":"e001650","DOI":"10.1136\/openhrt-2021-001650","article-title":"Patient delay and benefit of timely reperfusion in 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