{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:45:44Z","timestamp":1762868744847,"version":"build-2065373602"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Endogenous endophthalmitis (EE) is a rarely reported complication of infective endocarditis (IE). In an international series, we sought to determine the clinical and microbiological profile, treatment, and outcome of patients presenting with IE-related EE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Cases recorded from 2014 to 2023 in nine centres in Europe and the United States were collected. Results were compared to a matched control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sixty-six patients with EE were reported, mean age of 65.2 \u00b1 14.9 years, 71% (n = 47) male. Blood cultures were positive in 97% (64 cases) of patients, with a predominance of streptococci (46%, n = 30).<\/jats:p>\n                    <jats:p>As compared with the control group (n = 264), the EE group presented with more frequent diabetes (35% vs. 21%, P = 0.02), history of cirrhosis (9% vs. 3%, P = 0.04), glomerulonephritis (15% vs. 0.4%, P &amp;lt; 0.001), embolism before admission (92% vs. 55%, P &amp;lt; 0.001), and Janeway lesions (9% vs. 1%, P = 0.002). Streptococcal infection (46% vs. 26%, P = 0.001) was more frequent and Enterococcal infection (0% vs. 18%, P &amp;lt; 0.001) less frequent in the EE group.<\/jats:p>\n                    <jats:p>The main ocular symptoms were a decrease in visual acuity (96%), red eye (55%), and ocular pain (55%). Treatment of EE consisted of intravitreal antibiotic injection in 55 (83%) patients and vitrectomy in 17 (26%). Improvement of visual acuity was observed in 36 (55%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EE is a serious complication of IE with severe residual vision impairment. Patients with IE should be evaluated for ocular complications, since early detection of EE is crucial to prevent delays in management and to preserve visual function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeaf136","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:43:41Z","timestamp":1760618621000},"source":"Crossref","is-referenced-by-count":0,"title":["Endogenous endophthalmitis complicating infective endocarditis: a multicentre case-matched control cohort"],"prefix":"10.1093","volume":"5","author":[{"given":"Iris","family":"Layani","sequence":"first","affiliation":[{"name":"Department of Cardiology, La Timone Hospital Marseille , Boulevard Jean Moulin 13005, Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Arregle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Timone Hospital Marseille , Boulevard Jean Moulin 13005, Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian Santos","family":"Patarroyo","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases and Occupation Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW | Rochester, MN 55905 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurore","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Nord and Conception, Aix-Marseille University, Bd jean Moulin 13005 Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Mancini","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, APHM, INSERM, IRD, SESSTIM, Hop Timone, Public Health Department, BIOSTIC , Boullevard Jean Moulin 13005 Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Ternacle","sequence":"additional","affiliation":[{"name":"Unit\u00e9 M\u00e9dico-Chirurgicale des Valvulopathies H\u00f4pital Cardiologique Haut-L\u00e9v\u00eaque, CHU de Bordeaux , Avenue Magellan, Pessac 33600 ,","place":["France"]},{"name":"Centre de Recherche Cardio-Thoracique de Bordeaux, Univ. Bordeaux, INSERM, U1045 , Avenue Magellan, Pessac F-33604 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-6283","authenticated-orcid":false,"given":"Peter Laursen","family":"Graversen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9 2100, Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Foesbol","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9 2100, Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-344X","authenticated-orcid":false,"given":"Nuria","family":"Fern\u00e1ndez-Hidalgo","sequence":"additional","affiliation":[{"name":"Servei de Malalties Infeccioses, Hospital Universitari Vall D\u2019Hebron , Paseo de la Vall d'Hebron, 119-129 Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-4342","authenticated-orcid":false,"given":"Marco","family":"Tomasino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Vall D'Hebron , Paseo de la Vall d'Hebron 119-129, Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-5559","authenticated-orcid":false,"given":"Antonia","family":"Sambola","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Vall D'Hebron , Paseo de la Vall d'Hebron 119-129, Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Le Bot","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital , rue Abb\u00e9 Huet 2 r Henri Le Guilloux, Rennes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-5411","authenticated-orcid":false,"given":"Pierre","family":"Tattevin","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital , rue Abb\u00e9 Huet 2 r Henri Le Guilloux, Rennes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-3668","authenticated-orcid":false,"given":"Christophe","family":"Tribouilloy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amiens University Hospital , 1 rond-point du Professeur Christian Cabrol 80054, Amiens ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Timone Hospital Marseille , Boulevard Jean Moulin 13005, Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-7750","authenticated-orcid":false,"given":"Elisabeth","family":"Botelho-Nevers","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Saint-Etienne, 25 bd Pasteur, Saint-Etienne cedex 2 42055, Saint Etienne ,","place":["France"]},{"name":"13CIRI\u2014Centre International de Recherche en Infectiologie, Team GIMAP, Universit\u00e9 Jean Monnet, 10, Rue Tr\u00e9filerie \u2013 CS 8230142023 Saint-Etienne Cedex 2, Universit\u00e9 de Lyon, Inserm, U1111, CNRS, UMR530, Saint-Etienne F42023 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-2029","authenticated-orcid":false,"given":"David","family":"Boutoille","sequence":"additional","affiliation":[{"name":"Maladies Infectieuses et Tropicales\u2014CHU de Nantes 1 place Alexis-Ricordeau 44093, Nantes, Cedex"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0281-4505","authenticated-orcid":false,"given":"Mary","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Timone Hospital Marseille , Boulevard Jean Moulin 13005, Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Hubert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Timone Hospital Marseille , Boulevard Jean Moulin 13005, Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Tadrist","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Nord and Conception, Aix-Marseille University, Bd jean Moulin 13005 Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natacha","family":"Stolowy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Nord and Conception, Aix-Marseille University, Bd jean Moulin 13005 Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-6115","authenticated-orcid":false,"given":"Nahema","family":"Issa","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Maladies Infectieuses, H\u00f4pital Saint-Andr\u00e9, CHU de Bordeaux , 1 r Jean Burguet, 33000 Bordeaux ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Gouriet","sequence":"additional","affiliation":[{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e Infection , Boulevard Jean Moulin, 13005 Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-7077","authenticated-orcid":false,"given":"Larry M","family":"Baddour","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases and Occupation Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW | Rochester, MN 55905 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-9983","authenticated-orcid":false,"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Timone Hospital Marseille , Boulevard Jean Moulin 13005, Marseille 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