{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:07:28Z","timestamp":1782140848821,"version":"3.54.5"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018589","name":"Heart Care Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018589","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANMCO Research Centre"},{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici S.p.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>International guidelines recommend specific antithrombotic strategies for acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). However, real-world practice often diverges. This study aimed to assess antithrombotic therapy use in AMI patients admitted to cardiac care units (CCUs) across Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The EmploYEd Antithrombotic Therapies in Patients with Acute Coronary Syndromes Hospitalized in Italian Cardiac Care Units (EYESHOT-2) registry (NCT06316128) is an Italian nationwide, prospective study evaluating AMI management, focusing primarily on PCI-treated patients. Between 1 and 29 February 2024, 2806 patients were enrolled across 183 Italian CCUs. Percutaneous coronary intervention was performed in 83.5% of cases, while 16.5% received conservative treatment. Patients not undergoing PCI were older, more often female, had more comorbidities, and were more frequently diagnosed with NSTEMI. Pre-treatment with dual antiplatelet therapy before angiography was administered in 58.4% of PCI-treated patients. In the cath lab, most received oral P2Y12 inhibitors post-procedure. In-hospital outcomes favoured PCI, with lower rates of mortality, re-infarction, and major bleeding. Independent predictors of in-hospital bleeding among PCI patients included older age [odds ratio (OR) 1.05, 95% confidence interval (CI) 1.03\u20131.07, P &amp;lt; 0.0001], prior bleeding (OR 2.38, 95% CI 1.02\u20135.59, P = 0.046), recent surgery (OR 3.47, 95% CI 1.28\u20139.42, P = 0.01), Killip class III\/IV (OR 1.75, 95% CI 1.00\u20133.05, P = 0.049), and femoral access (OR 2.85, 95% CI 1.80\u20134.49, P &amp;lt; 0.0001), while, among patients treated conservatively, included history of anaemia (OR 4.83, 95% CI 2.24\u201310.41, P &amp;lt; 0.0001) and peripheral vascular disease (OR 2.75, 95% 1.24\u20136.12, P = 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This nationwide registry highlights improvements in AMI care in Italy but reveals persistent discrepancies between guideline-recommended and actual practice, underscoring the need for broader adoption of evidence-based strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>URL: http:\/\/www.clinicaltrials.gov. NCT06316128.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeaf154","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:35:29Z","timestamp":1763987729000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute pharmacologic management of myocardial infarction in patients undergoing percutaneous coronary intervention: insights from the Italian nationwide EYESHOT-2 prospective registry"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-1292","authenticated-orcid":false,"given":"Marco","family":"Zuin","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara , Via Savonarola 9, 0532 Ferrara ,","place":["Italy"]},{"name":"Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova , Via VIII Febbraio 2, 35122 Padua ,","place":["Italy"]},{"name":"Department of Cardiology, Madre Teresa Di Calcutta Hospital , AULSS 6, Ospedali Riuniti Padova Sud, Via Albere 30, 35043 Monselice ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donata","family":"Lucci","sequence":"additional","affiliation":[{"name":"Centro Studi ANMCO, Fondazione per il Tuo cuore , Via Alfonso La Marmora 34, 50121 Firenze ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-830X","authenticated-orcid":false,"given":"Paolo","family":"Calabr\u00f2","sequence":"additional","affiliation":[{"name":"Division of Cardiology, A.O.R.N. \u2018Sant'Anna e San Sebastiano\u2019 , Via Ferdinando Palasciano, 81100 Caserta ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-5751","authenticated-orcid":false,"given":"Antonino","family":"Nicosia","sequence":"additional","affiliation":[{"name":"Dipartimento CardioNeuroVascolare, ASP Ragusa , Via Dante Alighieri 102, 97100 Ragusa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Tizzani","sequence":"additional","affiliation":[{"name":"Dipartimento di Cardiologia, Ospedale degli Infermi , Via Rivalta 29, 10098 Rivoli, TO ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-2330","authenticated-orcid":false,"given":"Ciro","family":"Mauro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, \u2018A. Cardarelli\u2019 Hospital , Via Antonio Cardarelli 9, 80131 Naples ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Temporelli","sequence":"additional","affiliation":[{"name":"Division of Cardiac Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS , via per Revislate 13, 28013 Gattico-Veruno ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Gonzini","sequence":"additional","affiliation":[{"name":"Centro Studi ANMCO, Fondazione per il Tuo cuore , Via Alfonso La Marmora 34, 50121 Firenze ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Pietro","family":"Maggioni","sequence":"additional","affiliation":[{"name":"Centro Studi ANMCO, Fondazione per il Tuo cuore , Via Alfonso La Marmora 34, 50121 Firenze ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-8884","authenticated-orcid":false,"given":"Massimo","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Regional Hospital \u2018F. Miulli\u2019 , Strada Prov. 127 Acquaviva \u2013 Santeramo Km. 4, 70021 Acuqviva delle Fonti (Bari) ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-2234","authenticated-orcid":false,"given":"Furio","family":"Colivicchi","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Clinica e Riabilitativa, Presidio Ospedaliero San Filippo Neri - ASL Roma 1 , Via Giovanni Martinotti 20, 00135 Roma ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-0527","authenticated-orcid":false,"given":"Domenico","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Centro Studi ANMCO, Fondazione per il Tuo cuore , Via Alfonso La Marmora 34, 50121 Firenze ,","place":["Italy"]},{"name":"U.O.C. 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