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Acute inflammation is a host defence response overlapping with safe clearance of inflammation, termed as resolution of inflammation, co-ordinated by nutritionally originated fatty acid's interaction with immune-responsive enzymes. Especially processing of polyunsaturated fatty acids by immune-responsive lipoxygenase and cyclooxygenase orchestrates the biosynthesis of specialized proresolving mediators. In contrast, dysregulation due to an imbalanced lifestyle, such as an unhealthy diet, lack of sleep, and exercise\/low physical activity, drives non-resolving inflammation. Overall, the quality of fatty acids, enzymatic processing, on-time biosynthesis of SPMs, and precise activation of SPM-specific receptors operate cardiac repair in heart failure with reduced ejection fraction; however, the dysfunction of specific receptors, such as FPR2, drives obesogenic ageing and heart failure with preserved ejection fraction. Thus, the overlapping inflammation\u2013resolution signalling pathways that are essential for cardiac repair and the prevention of cardiac damage are highly relevant to cardiometabolic disorders and the subsequent development of heart failure. Therefore, future research is warranted to study lifestyle factors that maintain the balance of inflammation-resolution signalling in cardiac health and develop new therapeutic targets for resolution medicine.<\/jats:p>","DOI":"10.1093\/ehjopen\/oeaf157","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T13:16:30Z","timestamp":1764854190000},"source":"Crossref","is-referenced-by-count":8,"title":["Inflammation-resolution signalling in cardiac repair, remodelling, and heart failure"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-9354","authenticated-orcid":false,"given":"Ganesh V","family":"Halade","sequence":"first","affiliation":[{"name":"Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, University of South Florida , 560 Channelside Dr., Tampa, FL 33602 ,","place":["USA"]},{"name":"Hypertension and Kidney Research Center, Heart Institute, University of South Florida , Tampa, FL 33602 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"B\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet , Stockholm 17176 ,","place":["Sweden"]},{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm 17176 ,","place":["Sweden"]},{"name":"Universit\u00e9 de Lorraine , Inserm, DCAC, Nancy 54000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-8553","authenticated-orcid":false,"given":"Vasundhara","family":"Kain","sequence":"additional","affiliation":[{"name":"Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine, University of South Florida , 560 Channelside Dr., Tampa, FL 33602 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