{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:56:03Z","timestamp":1772128563778,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Cardiovascular Dynamics"},{"DOI":"10.13039\/100016924","name":"National Cerebral and Cardiovascular Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016924","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant-in-Aid for Scientific Research"},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["25K12264"],"award-info":[{"award-number":["25K12264"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["25K22628"],"award-info":[{"award-number":["25K22628"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["25K12304"],"award-info":[{"award-number":["25K12304"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23hk0102085h0002"],"award-info":[{"award-number":["23hk0102085h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23uk1024007h0001"],"award-info":[{"award-number":["23uk1024007h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009105","name":"Ministry of Internal Affairs and Communications","doi-asserted-by":"publisher","award":["JP225006004"],"award-info":[{"award-number":["JP225006004"]}],"id":[{"id":"10.13039\/501100009105","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Fund for Cardiovascular Diseases of National Cerebral and Cardiovascular Center","award":["JPMJPF2018"],"award-info":[{"award-number":["JPMJPF2018"]}]},{"DOI":"10.13039\/100020297","name":"Abiomed, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021086","name":"NTT-Research, Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Ventricular fibrillation (VF) is a frequent and life-threatening complication of acute myocardial infarction. Although the Impella device provides circulatory support solely to the left ventricle (LV), emerging reports have suggested that it may partially maintain haemodynamics even during VF. This study sought to examine this phenomenon under controlled experimental conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In eight Saanen goats, we recorded right atrial pressure (RAP), left atrial pressure (LAP), arterial pressure (AP), LV pressure, pulmonary artery flow (PAF), carotid artery flow (CAF), and coronary flow (CoF). We inserted an Impella CP and induced VF using direct current. In Protocol 1, we changed the stressed blood volume (SBV) by blood withdrawal\/infusion or pulmonary vascular resistance (PVR) by pulmonary microembolisation and measured the haemodynamics during VF with Impella P4 support (n = 1 each). In Protocol 2 (n = 6), we compared the central and peripheral blood flows between the baseline conditions and three Impella support levels (P0, P4, and P8) during VF. In Protocol 2, an increase of Impella support to P4 and P8 during VF significantly increased AP in a support level-dependent manner (P0, P4, and P8: 26.5 \u00b1 2.5, 57.7 \u00b1 8.7 and 72.0 \u00b1 15.3\u2005mmHg, respectively; P &amp;lt; 0.001) while lowering RAP and LAP. Impella partially maintained PAF (0, 1.2 \u00b1 0.6 and 1.6 \u00b1 0.9\u2005L\/min; P = 0.011), CAF (0, 177.6 \u00b1 26.3 and 235.5 \u00b1 44.1\u2005mL\/min; P &amp;lt; 0.001), and CoF (0, 68.5 \u00b1 32.0 and 57.8 \u00b1 20.6\u2005mL\/min; P = 0.002) during VF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Impella preserved systemic, cerebral, and coronary blood flow with adequate SBV and normal PVR conditions in a goat model of VF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeaf173","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:44:28Z","timestamp":1765889068000},"source":"Crossref","is-referenced-by-count":0,"title":["Impella preserves haemodynamics with adequate stressed blood volume and normal pulmonary vascular resistance in a goat model of ventricular fibrillation"],"prefix":"10.1093","volume":"6","author":[{"given":"Shohei","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Maruhashi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine , 1-15-1, Kitazato, Minami-ku, Sagamihara-shi, Kanagawa 252-0373 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Kakuuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-7831","authenticated-orcid":false,"given":"Takuya","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Research Promotion and Management, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Nishinaka","sequence":"additional","affiliation":[{"name":"Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-9362","authenticated-orcid":false,"given":"Keita","family":"Saku","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute , 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565 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