{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:28:24Z","timestamp":1786368504638,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/F\/21\/110047"],"award-info":[{"award-number":["RG\/F\/21\/110047"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T015713\/1"],"award-info":[{"award-number":["MR\/T015713\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Estriol (E3) is a natural estrogen produced during pregnancy whose physiological role in the adult cardiovascular and pulmonary systems remains poorly understood. Given the established association between estrogens and obesity, our study aims to investigate the interplay between obesity, E3, and their potential cardiopulmonary effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Effect of E3 on the cardiopulmonary system was evaluated in lean and high-fat diet-induced obese mice using right heart catheterization. Plasma triglyceride and adipokines were quantified using immunological assays, and circulating E3 levels were measured via LC-MS\/MS. In vitro experiments were carried out in a human adipocyte cell line and pulmonary artery smooth muscle cells (PASMCs) isolated from rats and patients with pulmonary arterial hypertension. E3 reduces visceral adipose tissue mass in vivo, primarily by attenuating adipocyte inflammation and proliferation. E3 treatment significantly reduced plasma leptin levels, contributing to improved metabolic profiles. In adipocytes, E3 reduced pro-proliferation and inflammatory markers while increasing the expression of antioxidant genes. Additionally, E3 reduced proliferation in isolated PASMCs and E3-induced signalling was observed to be mediated through the ER\u03b1 receptors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate, for the first time, that E3 reduces visceral adipose tissue mass, indicating its role in modulating adipose tissue characteristics while concurrently enhancing metabolic profiles. These results lay the groundwork for future research to investigate the role of E3 in disease prevention and its therapeutic application in cardiopulmonary disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag001","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:43:48Z","timestamp":1768394628000},"source":"Crossref","is-referenced-by-count":0,"title":["Estriol attenuates visceral adiposity and pulmonary artery smooth muscle cell proliferation via ER\u03b1-mediated signalling"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-8815","authenticated-orcid":false,"given":"Smriti","family":"Sharma","sequence":"first","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street, G4 0RE Glasgow ,","place":["UK"]},{"name":"Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna , Waehringer Guertel 18-20, Vienna A-1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P","family":"Dignam","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street, G4 0RE Glasgow ,","place":["UK"]},{"name":"Centre for Microvascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Aitchison","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street, G4 0RE Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Gaw","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street, G4 0RE Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Stasinopoulos","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh , 47 Little France Crescent, Edinburgh EH16 4TJ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Gebril","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street, G4 0RE Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-8430","authenticated-orcid":false,"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, Ulm University Medical Center , Eythstrasse 24, 89075 Ulm ,","place":["Germany"]},{"name":"German Center for Child and Adolescent Health (DZKJ), partner site Ulm , 89075 Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-2994","authenticated-orcid":false,"given":"Ruth","family":"Andrew","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh , 47 Little France Crescent, Edinburgh EH16 4TJ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R","family":"MacLean","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street, G4 0RE Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"2026081008320526000_oeag001-B1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0083-6729(08)60522-1","article-title":"Estrogens in pregnancy","volume":"35","author":"Levitz","year":"1977","journal-title":"Vitam Horm"},{"key":"2026081008320526000_oeag001-B2","first-page":"167","article-title":"Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions","volume":"102","author":"Schoen","year":"2003","journal-title":"Obstet Gynecol"},{"key":"2026081008320526000_oeag001-B3","first-page":"102","article-title":"HPL and estriol serum levels of placental perfusion as indexes of placental function in EPH gestosis and placental insufficiency","volume":"11","author":"Gitsch","year":"1980","journal-title":"Gynecol Obstet Invest"},{"key":"2026081008320526000_oeag001-B4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.canlet.2004.10.007","article-title":"Cytochrome P450-mediated metabolism of estrogens and its regulation in human","volume":"227","author":"Tsuchiya","year":"2005","journal-title":"Cancer Lett"},{"key":"2026081008320526000_oeag001-B5","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1210\/en.2006-0113","article-title":"Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: insights into the structural determinants favoring a differential subtype binding","volume":"147","author":"Zhu","year":"2006","journal-title":"Endocrinology"},{"key":"2026081008320526000_oeag001-B6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/endo.138.3.4979","article-title":"Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"2026081008320526000_oeag001-B7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000401992","article-title":"Clinical and experimental aspects of the anti-mammary carinogenic activity of estriol","volume":"5","author":"Lemon","year":"1977","journal-title":"Front Horm Res"},{"key":"2026081008320526000_oeag001-B8","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/humrep\/15.5.1028","article-title":"Safety and efficacy of oestriol for symptoms of natural or surgically induced menopause","volume":"15","author":"Takahashi","year":"2000","journal-title":"Hum Reprod"},{"key":"2026081008320526000_oeag001-B9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0378-5122(00)00157-2","article-title":"Comparison of the long-term effects of oral estriol with the effects of conjugated estrogen on serum lipid profile in early menopausal women","volume":"36","author":"Itoi","year":"2000","journal-title":"Maturitas"},{"key":"2026081008320526000_oeag001-B10","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/eurjpc\/zwae025","article-title":"Obesity and cardiovascular health","volume":"31","author":"Welsh","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"2026081008320526000_oeag001-B11","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1210\/jc.2017-01474","article-title":"Estrogen metabolism in abdominal subcutaneous and visceral adipose tissue in postmenopausal women","volume":"102","author":"Hetem\u00e4ki","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2026081008320526000_oeag001-B12","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/CIRCULATIONAHA.111.062927","article-title":"Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension\/clinical perspective","volume":"126","author":"White","year":"2012","journal-title":"Circulation"},{"key":"2026081008320526000_oeag001-B13","doi-asserted-by":"crossref","first-page":"1801524","DOI":"10.1183\/13993003.01524-2018","article-title":"Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension","volume":"53","author":"Mair","year":"2019","journal-title":"Eur Respir J"},{"key":"2026081008320526000_oeag001-B14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1513\/AnnalsATS.202006-671OC","article-title":"Insights from the menstrual cycle in pulmonary arterial hypertension","volume":"18","author":"Baird","year":"2021","journal-title":"Ann Am Thorac Soc"},{"key":"2026081008320526000_oeag001-B15","doi-asserted-by":"crossref","first-page":"2045894020908783","DOI":"10.1177\/2045894020908783","article-title":"Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension","volume":"10","author":"Denver","year":"2020","journal-title":"Pulm Circ"},{"key":"2026081008320526000_oeag001-B16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1183\/13993003.01083-2015","article-title":"Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function","volume":"47","author":"Ventetuolo","year":"2016","journal-title":"Eur Respir J"},{"key":"2026081008320526000_oeag001-B17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCRESAHA.122.321554","article-title":"BMPR2 mutation and metabolic reprogramming in pulmonary arterial hypertension","volume":"132","author":"Cuthbertson","year":"2023","journal-title":"Circ Res"},{"key":"2026081008320526000_oeag001-B18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2042-6410-3-6","article-title":"BMPR2 expression is suppressed by signaling through the estrogen receptor","volume":"3","author":"Austin","year":"2012","journal-title":"Biol Sex Differ"},{"key":"2026081008320526000_oeag001-B19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jneuroim.2003.12.015","article-title":"Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis","volume":"149","author":"Palaszynski","year":"2004","journal-title":"J Neuroimmunol"},{"key":"2026081008320526000_oeag001-B20","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/rccm.201103-0412OC","article-title":"A novel murine model of severe pulmonary arterial hypertension","volume":"184","author":"Ciuclan","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026081008320526000_oeag001-B21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.aca.2018.12.023","article-title":"Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry","volume":"1054","author":"Denver","year":"2019","journal-title":"Anal Chim Acta"},{"key":"2026081008320526000_oeag001-B22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.steroids.2015.03.016","article-title":"Steroid biosynthesis in adipose tissue","volume":"103","author":"Li","year":"2015","journal-title":"Steroids"},{"key":"2026081008320526000_oeag001-B23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-5122(90)90003-O","article-title":"Pharmacokinetics of oestrogens and progestogens","volume":"12","author":"Kuhl","year":"1990","journal-title":"Maturitas"},{"key":"2026081008320526000_oeag001-B24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000145784","article-title":"Human SGBS cells\u2014a unique tool for studies of human fat cell biology","volume":"1","author":"Fischer-Posovszky","year":"2008","journal-title":"Obes Facts"},{"key":"2026081008320526000_oeag001-B25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2012.03.007","article-title":"Estrogen and the cardiovascular system","volume":"135","author":"Knowlton","year":"2012","journal-title":"Pharmacol Ther"},{"key":"2026081008320526000_oeag001-B26","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/CIRCULATIONAHA.111.062927","article-title":"Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension","volume":"126","author":"White","year":"2012","journal-title":"Circulation"},{"key":"2026081008320526000_oeag001-B27","doi-asserted-by":"crossref","first-page":"e002636","DOI":"10.1161\/CIRCHEARTFAILURE.115.002636","article-title":"Right ventricular myocardial stiffness in experimental pulmonary arterial hypertension: relative contribution of fibrosis and myofibril stiffness","volume":"9","author":"Rain","year":"2016","journal-title":"Circ Heart Fail"},{"key":"2026081008320526000_oeag001-B28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jid.2019.07.719","article-title":"Estrogens counteract the profibrotic effects of TGF-beta and their inhibition exacerbates experimental dermal fibrosis","volume":"140","author":"Avouac","year":"2020","journal-title":"J Invest Dermatol"},{"key":"2026081008320526000_oeag001-B29","doi-asserted-by":"crossref","first-page":"14747","DOI":"10.1074\/jbc.M109.093039","article-title":"Estrogen inhibits transforming growth factor beta signaling by promoting Smad2\/3 degradation","volume":"285","author":"Ito","year":"2010","journal-title":"J Biol Chem"},{"key":"2026081008320526000_oeag001-B30","doi-asserted-by":"crossref","first-page":"166454","DOI":"10.1016\/j.bbadis.2022.166454","article-title":"Obesity induces adipose fibrosis and collagen cross-linking through suppressing AMPK and enhancing lysyl oxidase expression","volume":"1868","author":"Liu","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026081008320526000_oeag001-B31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12916-022-02672-y","article-title":"Obese visceral fat tissue inflammation: from protective to detrimental?","volume":"20","author":"Kolb","year":"2022","journal-title":"BMC Med"},{"key":"2026081008320526000_oeag001-B32","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2337\/db08-1054","article-title":"Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism","volume":"58","author":"Macotela","year":"2009","journal-title":"Diabetes"},{"key":"2026081008320526000_oeag001-B33","doi-asserted-by":"crossref","first-page":"951186","DOI":"10.3389\/fendo.2022.951186","article-title":"The importance of estradiol for body weight regulation in women","volume":"13","author":"Vigil","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026081008320526000_oeag001-B34","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.4049\/jimmunol.166.3.2080","article-title":"Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains","volume":"166","author":"Bebo","year":"2001","journal-title":"J Immunol"},{"key":"2026081008320526000_oeag001-B35","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1128\/MCB.25.8.2957-2968.2005","article-title":"17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization","volume":"25","author":"Ghisletti","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2026081008320526000_oeag001-B36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0960-0760(96)00175-6","article-title":"Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor","volume":"60","author":"Kurebayashi","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2026081008320526000_oeag001-B37","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1161\/hq1001.097064","article-title":"Catecholamines abrogate antimitogenic effects of 2-hydroxyestradiol on human aortic vascular smooth muscle cells","volume":"21","author":"Zacharia","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026081008320526000_oeag001-B38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/368237a0","article-title":"The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth","volume":"368","author":"Fotsis","year":"1994","journal-title":"Nature"},{"key":"2026081008320526000_oeag001-B39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0165-5728(94)90030-2","article-title":"Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis in mice","volume":"53","author":"Jansson","year":"1994","journal-title":"J Neuroimmunol"},{"key":"2026081008320526000_oeag001-B40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ana.10301","article-title":"Treatment of multiple sclerosis with the pregnancy hormone estriol","volume":"52","author":"Sicotte","year":"2002","journal-title":"Ann Neurol"},{"key":"2026081008320526000_oeag001-B41","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF01488797","article-title":"Estriol: a potent regulator of TNF and IL-6 expression in a murine model of endotoxemia","volume":"20","author":"Zuckerman","year":"1996","journal-title":"Inflammation"},{"key":"2026081008320526000_oeag001-B42","doi-asserted-by":"crossref","first-page":"105849","DOI":"10.1016\/j.jsbmb.2021.105849","article-title":"Adipose tissue estrogen production and metabolism in premenopausal women","volume":"209","author":"Hetemaki","year":"2021","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2026081008320526000_oeag001-B43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1158\/1940-6207.CAPR-10-0381","article-title":"Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland","volume":"4","author":"Subbaramaiah","year":"2011","journal-title":"Cancer Prev Res"},{"key":"2026081008320526000_oeag001-B44","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/sj.ijo.0802142","article-title":"Leptin: a review of its peripheral actions and interactions","volume":"26","author":"Margetic","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2026081008320526000_oeag001-B45","doi-asserted-by":"crossref","first-page":"PR13","DOI":"10.12659\/MSM.882030","article-title":"Waist circumference, ghrelin and selected adipose tissue-derived adipokines as predictors of insulin resistance in obese patients: preliminary results","volume":"17","author":"Stepien","year":"2011","journal-title":"Med Sci Monit"},{"key":"2026081008320526000_oeag001-B46","doi-asserted-by":"crossref","first-page":"3127S","DOI":"10.1093\/jn\/130.12.3127S","article-title":"Regulation of leptin production in humans","volume":"130","author":"Fried","year":"2000","journal-title":"J Nutr"},{"key":"2026081008320526000_oeag001-B47","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat Metab"},{"key":"2026081008320526000_oeag001-B48","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1097\/CCM.0b013e31817d1a92","article-title":"The effects of estrogen on pulmonary artery vasoreactivity and hypoxic pulmonary vasoconstriction: potential new clinical implications for an old hormone","volume":"36","author":"Lahm","year":"2008","journal-title":"Crit Care Med"},{"key":"2026081008320526000_oeag001-B49","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.vph.2008.02.001","article-title":"2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling","volume":"48","author":"Tofovic","year":"2008","journal-title":"Vascul Pharmacol"},{"key":"2026081008320526000_oeag001-B50","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1164\/rccm.201403-0483OC","article-title":"Sex-dependent influence of endogenous estrogen in pulmonary hypertension","volume":"190","author":"Mair","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026081008320526000_oeag001-B51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/cvr\/cvt064","article-title":"Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension","volume":"99","author":"Dempsie","year":"2013","journal-title":"Cardiovasc Res"},{"key":"2026081008320526000_oeag001-B52","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3143\/geriatrics.33.353","article-title":"Effect of estriol and bone mineral density of lumbar vertebrae in elderly and postmenopausal women","volume":"33","author":"Nishibe","year":"1996","journal-title":"Nihon Ronen Igakkai Zasshi"},{"key":"2026081008320526000_oeag001-B53","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1471-0528.1978.tb14895.x","article-title":"The effects of long-term therapy with oestriol succinate on the haemostatic mechanism in postmenopausal women","volume":"85","author":"Toy","year":"1978","journal-title":"Br J Obstet Gynaecol"},{"key":"2026081008320526000_oeag001-B54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molmet.2018.09.002","article-title":"Activation of estrogen receptor alpha induces beiging of adipocytes","volume":"18","author":"Santos","year":"2018","journal-title":"Mol Metab"},{"key":"2026081008320526000_oeag001-B55","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/jne.12152","article-title":"Sex differences in expression of oestrogen receptor alpha but not androgen receptor mRNAs in the foetal lamb brain","volume":"26","author":"Reddy","year":"2014","journal-title":"J Neuroendocrinol"},{"key":"2026081008320526000_oeag001-B56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1262\/jrd.2012-139","article-title":"Rat uterine oxytocin receptor and estrogen receptor alpha and beta mRNA levels are regulated by estrogen through multiple estrogen receptors","volume":"60","author":"Murata","year":"2014","journal-title":"J Reprod Dev"},{"key":"2026081008320526000_oeag001-B57","doi-asserted-by":"crossref","first-page":"e161284","DOI":"10.1172\/jci.insight.161284","article-title":"The different natural estrogens promote endothelial healing through distinct cell targets","volume":"8","author":"Davezac","year":"2023","journal-title":"JCI Insight"},{"key":"2026081008320526000_oeag001-B58","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/ani15101467","article-title":"Estradiol reverses ovariectomy-induced disruption of hypothalamic gene expression and behavior via modulation of gonadotropin releasing hormone and calcium signaling pathways","volume":"15","author":"Muhammad","year":"2025","journal-title":"Animals (Basel)"}],"container-title":["European Heart Journal Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjopen\/advance-article-pdf\/doi\/10.1093\/ehjopen\/oeag001\/66438821\/oeag001.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/6\/1\/oeag001\/66438821\/oeag001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/6\/1\/oeag001\/66438821\/oeag001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:32:23Z","timestamp":1786365143000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjopen\/article\/doi\/10.1093\/ehjopen\/oeag001\/8428383"}},"subtitle":[],"editor":[{"given":"Daniel F J","family":"Ketelhuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjopen\/oeag001","relation":{},"ISSN":["2752-4191"],"issn-type":[{"value":"2752-4191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]},"article-number":"oeag001"}}