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Planning of these therapy concepts requires a detailed understanding of phenotypes, responses to therapies, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The prospective Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg (TRUST) combines deep phenotypic, procedural, and follow-up information in a contemporary cohort of patients with cardiac arrhythmias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>TRUST is an investigator-initiated, prospective, cohort study enrolling consecutive patients at the UHZ Hamburg. Comprehensive baseline work-up, imaging, and biobanking at baseline is combined with follow-up using a combination of in-person visits, online questionnaires, and remote rhythm-monitoring. Enrolment started in March 2021 and is ongoing. This paper describes the design and the clinical characteristics of the first 1500 enrolled patients with verified baseline datasets (562 women (37%), median age 64 (IQR 55, 74) years). Overall, 1077\/1500 patients (71%) were seen for atrial fibrillation, 161\/1500 (11%) for ventricular tachycardia and premature ventricular complexes, 239\/1500 (16%) for supraventricular tachycardia, and 23\/1500 (2%) patients for other reasons. Ablations, rhythm surgery, or invasive procedures were performed in 1363\/1500 (91%) within 1 month after inclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This snapshot of the first 1500 patients enrolled in TRUST illustrates current characteristics and comorbidity burden in patients undergoing arrhythmia treatment. This rich data set will provide information on treatment patterns, detailed phenotypes, and follow-up, offering insights into the natural progression and treatment responses of arrhythmias in routine care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag002","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:11:02Z","timestamp":1768378262000},"source":"Crossref","is-referenced-by-count":2,"title":["Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-0203","authenticated-orcid":false,"given":"Julius","family":"Obergassel","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5595-4391","authenticated-orcid":false,"given":"Jan Leon","family":"Rie\u00df","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4951-5383","authenticated-orcid":false,"given":"Sandro","family":"Jaeckle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4165-9824","authenticated-orcid":false,"given":"Silke","family":"van Elferen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]},{"name":"Institute for Computational Systems Biology, Universit\u00e4t Hamburg , Albert-Einstein-Ring 8-10 22761 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-4151","authenticated-orcid":false,"given":"Moritz","family":"Nies","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-7484","authenticated-orcid":false,"given":"Niklas","family":"Schenker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner 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for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-733X","authenticated-orcid":false,"given":"Shinwan","family":"Kany","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-8564","authenticated-orcid":false,"given":"Laura","family":"Rottner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Frankfurt , Theodor-Stern-Kai 7, 60590 Frankfurt 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Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-6396","authenticated-orcid":false,"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-0197","authenticated-orcid":false,"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 42, 20246 Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner Site Hamburg\/Kiel\/L\u00fcbeck 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