{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:17:05Z","timestamp":1793146625783,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondos Europeos de Desarrollo Regional FEDER","award":["PI23\/01150"],"award-info":[{"award-number":["PI23\/01150"]}]},{"name":"Fondos Europeos de Desarrollo Regional FEDER","award":["CIBERCV16\/11\/00486"],"award-info":[{"award-number":["CIBERCV16\/11\/00486"]}]},{"name":"Conselleria de Educaci\u00f3n\u2014Generalitat Valenciana"},{"name":"CIBER Cardiovascular"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We explored the association between indexed left ventricular end-diastolic volume (iLVEDV) on cardiac magnetic resonance (CMR) and the risk of incident heart failure (HF) (stage C) in patients with suspected coronary heart disease without overt HF (stages A and B). We also examined the risk-modifying effect of left ventricular ejection fraction (LVEF) and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively included 5471 patients who underwent vasodilator stress CMR for suspected coronary artery disease and without a history of HF. Multivariate Cox proportional hazards regression adapted for competing events models assessed the relationship between iLVEDV and new-onset HF (stage C), considering LVEF status as a potential modifier. The mean age was 651 \u00b1 11.6 years, and 2123 (38.8%) were women. The medians of CMR-iLVEDV and CMR-LVEF were 67\u2005mL\/m2 (55\u201380) and 66% (58\u201372), respectively. At a median (p25% to p75%) follow-up of 5.1 years (2.3\u20138.2), we registered 287 new-onset HF diagnosis. iLVEDV was associated with a U-shaped risk of incident HF. The risk was most pronounced with an iLVEDV &amp;gt; 100\u2005mL\/m2 and &amp;lt;45\u2005mL\/m2. Notably, the association between iLVEDV and HF risk was influenced by LVEF status. In patients with LVEF &amp;lt; 50%, a higher risk was found in those with larger iLVEDV. On the contrary, LVEF &amp;gt; 60%, lower iLVEDV identified those at increased risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In subjects with higher LVEF, smaller left ventricle volumes identified a subset of patients with an increased risk of incident HF. These findings reveal a need for a better understanding of the pathophysiological mechanisms of HF with supranormal ejection fraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag009","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:57:17Z","timestamp":1769086637000},"source":"Crossref","is-referenced-by-count":2,"title":["Left ventricular diastolic volume on cardiac magnetic resonance and risk of incident heart failure"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7119","authenticated-orcid":false,"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, Avenida Blasco Ib\u00e1\u00f1ez 17, Valencia CP 46010 ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, Calle Men\u00e9ndez y Pelayo, 4, Valencia 46010 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red - Cardiovascular (CIBER-CV), Calle Monforte de Lemos, 3-5, Pabell\u00f3n 11, Madrid 28029 ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine and Odontology, University of Valencia, Avenida de Blasco Ib\u00e1\u00f1ez, 15, Valencia 46010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-2588","authenticated-orcid":false,"given":"Gema","family":"Mi\u00f1ana","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, Avenida Blasco Ib\u00e1\u00f1ez 17, Valencia CP 46010 ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, Calle Men\u00e9ndez y Pelayo, 4, Valencia 46010 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red - Cardiovascular (CIBER-CV), Calle Monforte de Lemos, 3-5, Pabell\u00f3n 11, Madrid 28029 ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine and Odontology, University of Valencia, Avenida de Blasco Ib\u00e1\u00f1ez, 15, Valencia 46010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-8443","authenticated-orcid":false,"given":"Miguel","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, Avenida Blasco Ib\u00e1\u00f1ez 17, Valencia CP 46010 ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, Calle Men\u00e9ndez y Pelayo, 4, Valencia 46010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8720-3999","authenticated-orcid":false,"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, Avenida Blasco Ib\u00e1\u00f1ez 17, Valencia CP 46010 ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, Calle Men\u00e9ndez y Pelayo, 4, Valencia 46010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-0696","authenticated-orcid":false,"given":"Agust\u00edn","family":"Fern\u00e1ndez-Cisnal","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, Avenida Blasco Ib\u00e1\u00f1ez 17, Valencia CP 46010 ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, Calle Men\u00e9ndez y Pelayo, 4, Valencia 46010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3527-0337","authenticated-orcid":false,"given":"Nerea","family":"Perez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, Calle Men\u00e9ndez y Pelayo, 4, Valencia 46010 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-8839","authenticated-orcid":false,"given":"Elena","family":"De Dios","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red - 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