{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:02:18Z","timestamp":1772636538434,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European grant \u2018EndoTAVI\u2019","award":["PO-FESR 2014\u20132020"],"award-info":[{"award-number":["PO-FESR 2014\u20132020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Post-implant thrombocytopenia and subclinical leaflet thrombosis (SLT) are two common phenomena, yet their potential interplay remains unexplored. This study aimed to determine whether early platelet dynamics differed in patients diagnosed with SLT on multidetector computed tomography (MDCT) compared with those without SLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 118 consecutive patients treated with self-expandable supra-annular and intra-annular prostheses were longitudinally analysed. Platelet count was assessed using the corrected platelet count (CPC) from baseline to day 7 (or hospital discharge) and at 30 days. Platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) were also measured as inflammatory markers. Spleen volume was assessed at baseline. MDCT was performed at 6-month follow-up to evaluate SLT. SLT, ranging from mild to severe, was detected in 22 patients at the 6-month MDCT follow-up. The SLT group had a lower baseline platelet count compared to the No-SLT group, with persistently lower levels from day 1 to day 7 post-implant. Platelet count was significantly lower in the SLT group on days 5 and 6 (CPC: 170 (IQR: 50) \u00d7 10\u00b3\/\u03bcL vs. 215 (IQR: 72) \u00d7 10\u00b3\/\u03bcL, P = 0.048; and 175 (IQR: 55) \u00d7 10\u00b3\/\u03bcL vs. 240 (IQR: 85) \u00d7 10\u00b3\/\u03bcL, P = 0.038). No significant differences were observed in PLR or LMR. Spleen volume was also significantly lower in the SLT group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrated a reversible thrombocytopenia during the first week post-implant, which was more pronounced in the SLT group than in the No-SLT group. Additionally, spleen volume was smaller in the SLT group, suggesting a potential interplay between these factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag011","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:39:28Z","timestamp":1769603968000},"source":"Crossref","is-referenced-by-count":0,"title":["Early post-TAVI thrombocytopenia recovery and subsequent subclinical leaflet thrombosis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-8486","authenticated-orcid":false,"given":"Marco","family":"Moscarelli","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Maria Eleonora Hospital , Viale Regione Siciliana Nord Ovest 1571, 90135 Palermo ,","place":["Italy"]},{"name":"Department of Surgery and Cancer, Hammersmith Hospital , Du Cane Road, London W12 0NN ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-5515","authenticated-orcid":false,"given":"Thanos","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Hammersmith Hospital , Du Cane Road, London W12 0NN ,","place":["UK"]},{"name":"Department of Cardiac Surgery, Hammersmith Hospital , Du Cane Road, London W12 0HS ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Casula","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Hammersmith Hospital , Du Cane Road, London W12 0NN ,","place":["UK"]},{"name":"Department of Cardiac Surgery, Hammersmith Hospital , Du Cane Road, London W12 0HS ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai-Linh Nguyen","family":"Trung","sequence":"additional","affiliation":[{"name":"GIGA Institutes, Cardiovascular Sciences and Metabolism, Department of Cardiology, CHU \u2013 B34 Quartier H\u00f4pital , Avenue de l'H\u00f4pital, 11 4000 Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petitjean","family":"H\u00e9l\u00e8ne","sequence":"additional","affiliation":[{"name":"GIGA Institutes, Cardiovascular Sciences and Metabolism, Department of Cardiology, CHU \u2013 B34 Quartier H\u00f4pital , Avenue de l'H\u00f4pital, 11 4000 Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oury","family":"Cecile","sequence":"additional","affiliation":[{"name":"GIGA Institutes, Cardiovascular Sciences and Metabolism, Department of Cardiology, CHU \u2013 B34 Quartier H\u00f4pital , Avenue de l'H\u00f4pital, 11 4000 Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Salardino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Maria Eleonora Hospital , Viale Regione Siciliana Nord Ovest 1571, 90135 Palermo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Pernice","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Maria Eleonora Hospital , Viale Regione Siciliana Nord Ovest 1571, 90135 Palermo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregorio","family":"Zaccone","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Maria Eleonora Hospital , Viale Regione Siciliana Nord Ovest 1571, 90135 Palermo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Milo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maria Eleonora Hospital , Viale Regione Siciliana Nord Ovest 1571, 90135 Palermo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Speziale","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Santa Maria Hospital , Via Antonio De Ferrariis 22, 70124 Bari ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-9519","authenticated-orcid":false,"given":"Khalil","family":"Fattouch","sequence":"additional","affiliation":[{"name":"Kore University of Medicine, Piazza della Universit\u00e0 , 94100 Enna ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Lancellotti","sequence":"additional","affiliation":[{"name":"GIGA Institutes, Cardiovascular Sciences and Metabolism, Department of Cardiology, CHU \u2013 B34 Quartier H\u00f4pital , Avenue de l'H\u00f4pital, 11 4000 Li\u00e8ge 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