{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:12Z","timestamp":1792794072069,"version":"4.5.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Heart Association-Strategically Focused Research Network Grant in Disparities in Cardio-Oncology","award":["#847740"],"award-info":[{"award-number":["#847740"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association-Strategically Focused Research Network Grant in Disparities in Cardio-Oncology","award":["#863620"],"award-info":[{"award-number":["#863620"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Department of Defense Prostate Cancer Research Program\u2019s Physician Research","award":["#HT94252310158"],"award-info":[{"award-number":["#HT94252310158"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Malignancy-related pericardial effusion (MRPE) is a serious complication of advanced cancer, potentially leading to life-threatening cardiac tamponade. While both pericardiocentesis and surgical pericardial window are used for management, data on comparative efficacy and safety remain heterogeneous. This study aims to compare the efficacy and safety of pericardiocentesis vs. surgical pericardial window in the management of the first occurrence of MRPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Cochrane, and Google Scholar up until May 2025. Articles directly comparing pericardiocentesis to surgical pericardial window, which include patients with MRPE, have first occurrence procedure outcome data, and published in English, were included. Our outcomes consisted of procedure failure (composite of inability to drain, inability to relieve symptoms, or recurrence of effusion), bleeding, infection, pneumothorax, supraventricular tachyarrhythmias (SVT), and death. A total of six articles met our inclusion criteria, representing a total of 1369 patients, 1086 of whom underwent pericardiocentesis and 253 surgical pericardial windows. Procedure failure was significantly higher in the pericardiocentesis group when compared to the surgical approach [odds ratio (OR): 2.99, 95% CI 1.10\u20138.14, P = 0.03], while more deaths were reported in the surgical pericardial window group (OR: 0.68, 95%CI 0.46\u20130.99, P = 0.05). There was no difference between the two groups for bleeding (P = 0.051), infection (P = 0.11), pneumothorax (P = 0.56), or SVT (P = 0.31).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both pericardiocentesis and surgical pericardial window showed comparable rates of infection, bleeding, SVT, and pneumothorax in patients with MRPE. However, due to the nature of the procedures, a lower failure rate was seen in surgical pericardial window with a higher death rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag018","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:50:06Z","timestamp":1770295806000},"source":"Crossref","is-referenced-by-count":2,"title":["Pericardiocentesis vs. surgical pericardial window for first occurrence of malignancy-related pericardial effusion: a meta-analysis of retrospective studies"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4584-3308","authenticated-orcid":false,"given":"Tarek","family":"Nahle","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , 1410 Laney Walker Blvd, CB-3540, Augusta, GA 30912 ,","place":["USA"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bhave","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Abou","family":"Zeid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universit\u00e9 Saint-Joseph de Beyrouth , Beirut ,","place":["Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-4247","authenticated-orcid":false,"given":"Mohamad","family":"El Shami","sequence":"additional","affiliation":[{"name":"Department of Medicine, Corewell Health, Michigan State University , Grand Rapids, MI 49503 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viraj R","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , 1410 Laney Walker Blvd, CB-3540, Augusta, GA 30912 ,","place":["USA"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8361-9068","authenticated-orcid":false,"given":"Omar M","family":"Makram","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , 1410 Laney Walker Blvd, CB-3540, Augusta, GA 30912 ,","place":["USA"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]},{"name":"Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-7956","authenticated-orcid":false,"given":"Harikrishnan Hyma","family":"Kunhiraman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , 1410 Laney Walker Blvd, CB-3540, Augusta, GA 30912 ,","place":["USA"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Abou Khalil","sequence":"additional","affiliation":[{"name":"Tulane Research Innovation for Arrhythmia Discovery (TRIAD), Cardiac Electrophysiology, Tulane University School of Medicine , New Orleans, LA 70118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyoo A","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Program, Cleveland Clinic Abu Dhabi , Abu Dhabi ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-8578","authenticated-orcid":false,"given":"Nausheen","family":"Akhter","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Feinberg School of Medicine, Northwestern University , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medicine , New York, NY 10065 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Services, Barts Heart Centre, St Bartholomew\u2019s Hospital , London ,","place":["UK"]},{"name":"University College London Hospital London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-092X","authenticated-orcid":false,"given":"Jean-Sebastien","family":"Rachoin","sequence":"additional","affiliation":[{"name":"Medicine, Cooper Medical School of Rowan University , Camden, NJ 08103 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal L","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , 1410 Laney Walker Blvd, CB-3540, Augusta, GA 30912 ,","place":["USA"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avirup","family":"Guha","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , 1410 Laney Walker Blvd, CB-3540, Augusta, GA 30912 ,","place":["USA"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA 30912 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"2026041617121734700_oeag018-B1","first-page":"8","article-title":"Pericardial effusion in oncological patients: current knowledge and principles of management","volume":"10","author":"Mori","year":"2024","journal-title":"Cardiooncology"},{"key":"2026041617121734700_oeag018-B2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.amjcard.2020.12.092","article-title":"Pericardial involvement in cancer","volume":"145","author":"Chahine","year":"2021","journal-title":"Am J 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