{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:02:05Z","timestamp":1781247725165,"version":"3.54.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare","award":["RS-2023-00265440"],"award-info":[{"award-number":["RS-2023-00265440"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Pacing-associated heart failure (PaHF) has emerged as a clinically significant complication in patients with pacemakers, yet its prognostic factors and optimal management remain underexplored. We aimed to assess mortality risk and the clinical impact of cardiac resynchronisation therapy (CRT)-upgrade and heart failure (HF) medications in patients with PaHF using a nationwide real-world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed 4166 patients who developed PaHF after de novo permanent pacemaker implantation using a nationwide real-world cohort from the Korean National Health Insurance Service. To address confounding and immortal-time bias, propensity score matching and time-dependent Cox regression models were applied. During a median follow-up of 1.9 years, 330 patients underwent CRT-upgrade in addition to standard HF medical therapy, while 3836 received guideline-directed HF medications alone. Increasing age (HR = 1.05 per year, 95% CI 1.04\u20131.06, P &amp;lt; 0.001), male sex (HR = 1.41, 95% CI 1.16\u20131.71, P &amp;lt; 0.001), diabetes (HR = 1.28, 95% CI 1.02\u20131.60, P = 0.035), and chronic kidney disease or end-stage renal disease (HR = 1.69, 95% CI 1.32\u20132.17, P &amp;lt; 0.001) were independently associated with increased all-cause mortality. In contrast, CRT-upgrade (HR = 0.36, 95% CI 0.26\u20130.50, P &amp;lt; 0.001), angiotensin receptor\u2013neprilysin inhibitor (ARNI) use (HR = 0.37, 95% CI 0.19\u20130.68, P = 0.004), and beta-blockers (HR = 0.80, 95% CI 0.64\u20130.99, P = 0.042) were strongly associated with improved survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide real-world cohort, CRT-upgrade was associated with a significant reduction in all-cause mortality compared with medical therapy alone in patients with PaHF. These findings support the prognostic importance of device-based therapy in combination with contemporary HF medical treatment in real-world clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag027","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:38:39Z","timestamp":1771072719000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term mortality and treatment outcomes in pacemaker-associated heart failure: insights from a nationwide propensity-matched study"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-5597","authenticated-orcid":false,"given":"Young Jun","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine , 20 Ilsan-ro, Wonju 26426 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-4220","authenticated-orcid":false,"given":"Sungjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-238X","authenticated-orcid":false,"given":"Sungjun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]},{"name":"Medical AI Research Center, Research Institute for Future Medicine, Samsung Medical Center , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunga","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]},{"name":"Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-3428","authenticated-orcid":false,"given":"Ju Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-9691","authenticated-orcid":false,"given":"Kyoung-Min","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Keun","family":"On","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-0594","authenticated-orcid":false,"given":"Seung-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Seoul 06351 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"2026061202333087600_oeag027-B1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ejhf.1427","article-title":"Clinical features, predictors, and long-term prognosis of pacing-induced cardiomyopathy","volume":"21","author":"Cho","year":"2019","journal-title":"Eur J Heart 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