{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:59:23Z","timestamp":1776376763177,"version":"3.51.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Norwegian Regional Health Authorities","award":["22\/00793-5"],"award-info":[{"award-number":["22\/00793-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Population-based data on cardiac-related symptoms in individuals without diagnosed cardiac disease remain limited, despite important implications for early detection and management. We aimed to assess the prevalence of self-reported symptoms and the association with quality of life (QoL) among adults aged \u226565 years with \u22651 additional stroke risk factor, but without diagnosed cardiac disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This is a cross-sectional study of the NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial population at baseline. NORSCREEN is an ongoing, nationwide, randomized atrial fibrillation screening study in adults aged \u226565 years at increased risk of stroke (CHA2DS2-VA \u22652). All participants completed a baseline questionnaire capturing clinical information, symptoms, and QoL. Of the 50 549 participants enrolled from 2023 to 2025, 39 281 (78%) reported no diagnosed cardiac disease. Among those, 17 069 (43%) reported cardiac-related symptoms compared to 7551 (67%) of 11 268 individuals with known cardiac disease. The most common symptoms were fatigue, exertional dyspnoea, and tachycardia. Female sex [adjusted odds ratio 1.66, (95% CI 1.58\u20131.75)], physical inactivity [1.43 (1.32\u20131.55)], current smoking [1.24 (1.12\u20131.37)], age &amp;lt;75 years [1.14 (1.08\u20131.20)], living alone [1.13 (1.07\u20131.20)], and comorbidities including chronic obstructive pulmonary disease [6.51 (5.63\u20137.54)] and anxiety [3.99 (3.64\u20134.38)] were associated with cardiac-related symptoms. Symptomatic individuals reported significantly lower RAND-36 QoL scores across all domains compared to those without symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort of individuals aged \u226565 years at increased risk of stroke, but without diagnosed cardiac disease, nearly half reported cardiac-related symptoms, which were associated with substantially reduced QoL. These findings suggest there might be unmet needs in identifying and managing cardiovascular disease.<\/jats:p>\n                    <jats:p>Registration: Clinical trials: NCT05914883<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag032","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:57:13Z","timestamp":1771505833000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiac-related symptoms in individuals aged \u226565 years without diagnosed cardiac disease: insights from the NORSCREEN trial"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-9852","authenticated-orcid":false,"given":"Jarle","family":"Jortveit","sequence":"first","affiliation":[{"name":"Department of Cardiology, S\u00f8rlandet Hospital HF , Arendal, Box 416, Lundsiden, Kristiansand 4604 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