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This viewpoint explains the role of obesity-driven inflammation in the development and management of atherosclerosis in women. Abdominal obesity promotes a proinflammatory and prothrombotic environment that accelerates atherogenesis. Women with higher inflammatory biomarker levels and experience sex-specific risk-modifying stages, such as polycystic ovary syndrome, pregnancy-related conditions, and menopause, have higher risk for cardiovascular events, including atherosclerosis. We review evidence for antiobesity and anti-inflammatory therapies. Integrating obesity and inflammation into ASCVD care in women requires targeted screening, risk assessment, and sex-stratified research approaches. This viewpoint highlights the relation between obesity and atherosclerosis.<\/jats:p>","DOI":"10.1093\/ehjopen\/oeag055","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:41:35Z","timestamp":1774615295000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond the conventional risk factors in the management of atherosclerosis in women: a call to action for careful consideration of obesity and inflammation"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-0334","authenticated-orcid":false,"given":"Mirvat","family":"Alasnag","sequence":"first","affiliation":[{"name":"Cardiac Center, King Fahd Armed Forces Hospital , PO Box 126418, Alcorniche Jeddah 21372 ,","place":["Saudi 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