{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:09:23Z","timestamp":1783181363600,"version":"3.54.6"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Research Committee"},{"DOI":"10.13039\/501100011769","name":"St Olavs Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019902","name":"Faculty of Medicine and Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006397","name":"NTNU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006397","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liaison Committee for Education","award":["2017\/38202"],"award-info":[{"award-number":["2017\/38202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Exercise is effective in preventing and treating cardiovascular disease. High-intensity interval training (HIIT) has shown promising effects on cardiorespiratory fitness and quality of life (QoL). However, evidence of risks and beneficial effects of HIIT in patients at high risk of ventricular arrhythmias (VA) is limited. This study evaluated the effects of HIIT on peak oxygen uptake (VO2peak), QoL, and the burden of VA in patients with an implantable cardioverter defibrillator (ICD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Fifty-six ICD patients with coronary artery disease (CAD) or non-ischaemic dilated cardiomyopathy (DCM) were randomized to a 12-week supervised HIIT programme with intervals at 85\u201395% of maximum heart rate, or to usual activity (control). Primary outcomes were changes in VO2peak and QoL. Secondary outcomes included changes in VA burden, with or without ICD therapy. High-intensity interval training increased VO2peak by 7.0% vs. no change in the control group, with a between-group difference of 1.7\u2005mL\/kg\/min (95% confidence interval, 0.7\u20132.6; P &amp;lt; 0.001). After correction for multiple testing, HIIT improved QoL on the SF-36 health change domain, while most other domains showed favourable but non-significant trends. Clinically relevant VA occurred in two patients during baseline exercise testing and in two patients during HIIT. Sustained ventricular tachycardia incidence was lower in the HIIT group (P = 0.037), although the number of events was small and unevenly distributed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In ICD patients with CAD or non-ischaemic DCM, a supervised 12-week HIIT programme significantly improved exercise capacity and QoL. However, its overall impact on VA remains inconclusive, and the risk of exercise-induced arrhythmias remains a concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag058","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:43:40Z","timestamp":1775735020000},"source":"Crossref","is-referenced-by-count":1,"title":["Effect of high-intensity interval training on peak oxygen uptake, quality of life, and ventricular arrhythmias in patients with an implantable cardioverter defibrillator: a randomized controlled trial"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-5107","authenticated-orcid":false,"given":"Mathias","family":"Nyman","sequence":"first","affiliation":[{"name":"Clinic of Cardiology, St.Olavs Hospital, Trondheim University Hospital , Postboks 3250 Torgarden, 7006 Trondheim ,","place":["Norway"]},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU) , Postboks 8905, 7491 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-4838","authenticated-orcid":false,"given":"Ole Christian","family":"Mj\u00f8lstad","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St.Olavs Hospital, Trondheim University Hospital , Postboks 3250 Torgarden, 7006 Trondheim ,","place":["Norway"]},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU) , Postboks 8905, 7491 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Cecilie","family":"Dale","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St.Olavs Hospital, Trondheim University Hospital , Postboks 3250 Torgarden, 7006 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-7395","authenticated-orcid":false,"given":"Brage H\u00f8yem","family":"Amundsen","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St.Olavs Hospital, Trondheim University Hospital , Postboks 3250 Torgarden, 7006 Trondheim ,","place":["Norway"]},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU) , Postboks 8905, 7491 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Rossvoll","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St.Olavs Hospital, Trondheim University Hospital , Postboks 3250 Torgarden, 7006 Trondheim ,","place":["Norway"]},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU) , Postboks 8905, 7491 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-3587","authenticated-orcid":false,"given":"Ulrik","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU) , Postboks 8905, 7491 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P\u00e5l","family":"Loennechen","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St.Olavs Hospital, Trondheim University Hospital , Postboks 3250 Torgarden, 7006 Trondheim ,","place":["Norway"]},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU) , Postboks 8905, 7491 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"2026041617122810800_oeag058-B1","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1177\/2047487316671181","article-title":"The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: a systematic review and meta-analysis of randomized and non-randomized studies - 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