{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T17:59:07Z","timestamp":1780768747797,"version":"3.54.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["204977"],"award-info":[{"award-number":["204977"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>New-onset atrial fibrillation (NOAF) frequently occurs in critically ill patients admitted to intensive care units (ICUs), yet definitions and outcome reporting remain inconsistent across clinical studies. This heterogeneity impedes evidence synthesis and limits the development of standardized management strategies. A scoping review was conducted following the Arksey and O\u2019Malley framework and reported using PRISMA-ScR guidelines. Electronic databases were searched from 1990 to 2024 for randomized controlled trials and observational studies reporting on NOAF in acutely unwell ICU patients. Data on arrhythmia definitions and reported outcomes were extracted and categorized using the ISPOR framework. This is the first study to systematically examine and compare diagnostic criteria for NOAF in ICU-based research. Out of 8477 records, 44 studies (4 RCTs, 12 prospective, and 28 retrospective observational studies) met inclusion criteria. Significant heterogeneity was found in how NOAF was defined, including arrhythmia duration thresholds, diagnostic criteria, and heart rate cut-offs. Outcomes were primarily clinician-reported (n = 101), followed by observer-reported (n = 74), biomarker (n = 25), and patient-reported outcomes (n = 4), with no performance outcomes identified. Common outcomes included rhythm and heart rate control, arrhythmia recurrence, mortality, and length of stay, though definitions and timeframes varied considerably across studies. This review identifies substantial methodological variation in both the definition and measurement of NOAF in ICU research. The findings are immediately applicable to clinical practice, enabling ICU teams to benchmark diagnostic and monitoring approaches, align practice with guideline-based definitions, and identify patients who may benefit from structured post-discharge follow-up. They also provide evidence for the importance of the development a Core Outcome Set for NOAF.<\/jats:p>","DOI":"10.1093\/ehjopen\/oeag075","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:47:38Z","timestamp":1778240858000},"source":"Crossref","is-referenced-by-count":0,"title":["Definitions and outcomes reported in studies investigating the management of new onset atrial fibrillation in acutely unwell patients admitted to the intensive care unit: a scoping review"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-3297","authenticated-orcid":false,"given":"Brian W","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , 6 West Derby Street, Liverpool L78TX ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"University Hospitals of Liverpool Group, Royal Liverpool University Hospital, Department of Critical Care Medicine , Mount Vernon Street, Liverpool L78YE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joby","family":"Mathew","sequence":"additional","affiliation":[{"name":"Liverpool School of Medicine, University of Liverpool , Cedar House, Ashton Street, Liverpool L69 3GE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calum","family":"Voller","sequence":"additional","affiliation":[{"name":"Liverpool School of Medicine, University of Liverpool , Cedar House, Ashton Street, Liverpool L69 3GE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaraidh A","family":"Hill","sequence":"additional","affiliation":[{"name":"Liverpool Reviews and Implementation Group (LRiG), University of Liverpool, Department of Health Data Science, Institute of Population Health , Waterhouse Building, Block B, Brownlow Building, Block B, Liverpool L69 3GF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronagh","family":"Blackwood","sequence":"additional","affiliation":[{"name":"Wellcome Wolfson Institute for Experimental Medicine, Queens University Belfast , 97 Lisburn Road, Belfast BT9 7BL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Williams","sequence":"additional","affiliation":[{"name":"University Hospitals of Liverpool Group, Royal Liverpool University Hospital, Department of Critical Care Medicine , Mount Vernon Street, Liverpool L78YE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hall","sequence":"additional","affiliation":[{"name":"University Hospitals of Liverpool Group, Royal Liverpool University Hospital, Department of Critical Care Medicine , Mount Vernon Street, Liverpool L78YE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Wilson","sequence":"additional","affiliation":[{"name":"Liverpool Heart and Chest Hospital NHS Foundation Trust , Thomas Drive, Liverpool L14 3PE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudie H","family":"Lobban","sequence":"additional","affiliation":[{"name":"Arrhythmia Alliance, Heart Rhythm Alliances and STARS , Celixir House, Stratford Business and Technology Park, Innovation Way, Stratford upon Avon, Warickshire CV37 7GZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , 6 West Derby Street, Liverpool L78TX ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Fredrik Bajers Vej 7K, 9920 Aalborg ,","place":["Denmark"]},{"name":"Medical University of Bialystok , Jana Killnskiego 1, 15-089 Bialystok ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-8798","authenticated-orcid":false,"given":"Ingeborg D","family":"Welters","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , 6 West Derby Street, Liverpool L78TX ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"University Hospitals of Liverpool Group, Royal Liverpool University Hospital, Department of Critical Care Medicine , Mount Vernon Street, Liverpool L78YE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"2026060613014006900_oeag075-B1","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"2026060613014006900_oeag075-B2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jcrc.2019.06.015","article-title":"Risk factors for new-onset atrial fibrillation on the general adult ICU: a systematic 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