{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:43:56Z","timestamp":1788385436127,"version":"build-2803163510"},"reference-count":223,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Currently, there is no established treatment for post-ischaemic reperfusion-related injury, namely reperfusion injury (RI), which paradoxically exacerbates microvascular and tissue damage in any reperfused ischaemic organ territory. During the ischaemic phase, the autoregulatory apparatus in a subtended organ region temporarily loses its pressure-regulating function because of the combined effects of drastically increased oxygen demand and ischaemic insult. Therefore, it cannot protect the hypoxically injured distal capillary bed from the detrimental effect of the sudden and uncontrolled pressure rise that occurs during the initial phase of reperfusion. This acute capillary barotrauma caused by abruptly initiated reperfusion at systemic pressure can be regarded as an iatrogenic trigger for subsequent damage in the reperfused organ territory. From this haemodynamic perspective, RI can be redefined as a \u2018capillary hyperpressurization syndrome\u2019, dictated by the \u2018initial reperfusion pressure\u2019. Accordingly, initiating reperfusion gently at lower pressures [pressure-controlled reperfusion (PCR)] and maintaining it at that level until protective autoregulatory myogenic control mechanisms recover may provide substantial benefit in limiting the progressive damage caused by post-ischaemic abrupt and full-pressure reperfusion. In this review, we revisit RI from this haemodynamic perspective and suggest that the same pathomechanism\u2014namely, acute exposure of ischaemically injured microvascular endothelium to an uncontrolled pressure rise during the initial reperfusion phase\u2014predominantly dictates post-reperfusion damage in the heart and in other organ ischaemia\u2013reperfusion settings, where PCR techniques may help limit post-reperfusion damage.<\/jats:p>","DOI":"10.1093\/ehjopen\/oeag098","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:48:56Z","timestamp":1780487336000},"source":"Crossref","is-referenced-by-count":1,"title":["Reperfusion injury from a haemodynamic standpoint and role of pressure-controlled reperfusion in avoiding reperfusion injury"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-1614","authenticated-orcid":false,"given":"Murat","family":"Sezer","sequence":"first","affiliation":[{"name":"Department of Cardiology, Acibadem International Hospital , Yesilkoy, Yesilkoy Istanbul Cd. No:82, 34149 Istanbul ,","place":["Turkey"]},{"name":"Faculty of Medicine, Istanbul University , Turgut Ozal Millet Cd., 34093 Istanbul ,","place":["Turkey"]},{"name":"Department of Cardiology, Istanbul University , Turgut Ozal Millet Cd., 34093 Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-2576","authenticated-orcid":false,"given":"Ahmet","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC, Heart Centre, Amsterdam Cardiovascular Sciences , Meibergdreef 9, 1105 AZ Amsterdam ,","place":["the Netherlands"]},{"name":"Emergency Department, Gomec State Hospital , Ayanoglu Sk. No:14, 10715 Balikesir ,","place":["Turkey"]},{"name":"Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital , Turgut Ozal Bulvari No:11, 34303 Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-2391","authenticated-orcid":false,"given":"Yaren","family":"Alan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Istanbul University , Turgut Ozal Millet Cd., 34093 Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilke Kara","family":"Tas","sequence":"additional","affiliation":[{"name":"Emergency Department, Gomec State Hospital , Ayanoglu Sk. No:14, 10715 Balikesir ,","place":["Turkey"]},{"name":"Department of Pathology, Istanbul Training and Research Hospital , Org. Abdurrahman Nafiz Gurman Cd. No:24, 34098 Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koc University School of Medicine , Davutpasa Cd. 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