{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:40:40Z","timestamp":1789846840699,"version":"4.0.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CM30-124112"],"award-info":[{"award-number":["33CM30-124112"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CM30-140336"],"award-info":[{"award-number":["33CM30-140336"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32003B_207881"],"award-info":[{"award-number":["32003B_207881"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Overweight and obesity are common among patients with acute coronary syndromes (ACS), yet the long-term cardiovascular consequences of post-ACS weight change remain uncertain. We investigated the association between 1-year weight change after ACS and 5-year clinical outcomes in overweight and obese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed 1473 overweight and obese ACS participants from the Swiss ELIPS cohort with available weight measurements. Hazard ratios (HRs) were estimated per 1% and 5% weight change for the 5-year risk of major adverse cardiovascular events (MACE), defined as cardiovascular death, non-fatal myocardial infarction, coronary revascularization, stroke, or transient ischaemic attack. Models were adjusted for age, sex, body mass index (BMI), smoking, total cholesterol, hypertension, diabetes, and estimated glomerular filtration rate. Predefined subgroups included BMI \u2265 27\u2005kg\/m2 vs. 25\u201327\u2005kg\/m2. Among the participants (15.1% women, mean age 61.5 years), the median BMI was 28.1\u2005kg\/m2 (67% BMI \u2265 27\u2005kg\/m2). Median 1-year weight change was 0%; 47.5% lost weight and 18.7% achieved &amp;gt;5% weight loss. Patient characteristics associated with weight loss were older age, higher BMI, non-smoking status, and participation in cardiac rehabilitation. During follow-up, 278 MACE events occurred. Weight loss was associated with a lower risk of MACE [multivariate-adjusted HR per 5%: 0.90, 95% confidence interval (CI): 0.82\u20131.00, P = 0.04]. The association was stronger in patients with BMI \u2265 27\u2005kg\/m2 (adj HR per 5% 0.87, 95% CI: 0.77\u20130.97) compared to those with BMI 25\u201327\u2005kg\/m2 (adj HR per 5% 1.01, 95% CI: 0.85\u20131.20, interaction P = 0.16).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overweight and obese ACS patients who lose weight may have a lower risk of cardiovascular events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag105","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:23:19Z","timestamp":1780917799000},"source":"Crossref","is-referenced-by-count":1,"title":["Weight change and long-term cardiovascular outcomes in overweight and obese patients after acute coronary syndromes"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5063-4848","authenticated-orcid":false,"given":"Louise","family":"Artels","sequence":"first","affiliation":[{"name":"Department of Cardiology, Lausanne University Hospitals , Rue du Bugnon 46, Lausanne 1011 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-4978","authenticated-orcid":false,"given":"C\u00e9dric","family":"Follonier","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Cardiology, Geneva University Hospitals , Rue Gabrielle-Perret-Gentil 4, Geneva 1205 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Baggio","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , Mittelstrasse 43, Bern 3012 ,","place":["Switzerland"]},{"name":"Institute of Psychology, University of Lausanne , Geopolis, Chavannes-pr\u00e8s-Renens 1015 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carballo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Geneva University Hospitals , Rue Gabrielle-Perret-Gentil 4, Geneva 1205 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-3505","authenticated-orcid":false,"given":"David","family":"Nanchen","sequence":"additional","affiliation":[{"name":"Department of Ambulatory Care and Community Medicine, Lausanne University , Route de la Corniche 21, Lausanne 1010 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostantinos","family":"Koskinas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital , Freiburgstrasse 18, Bern 3010 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M","family":"Matter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University of Zurich , R\u00e4mistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-3026","authenticated-orcid":false,"given":"Lorenz","family":"R\u00e4ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital , Freiburgstrasse 18, Bern 3010 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-5799","authenticated-orcid":false,"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lausanne University Hospitals , Rue du Bugnon 46, Lausanne 1011 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