{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:49:20Z","timestamp":1791492560559,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Right ventricular dysfunction (RVD) is common in cardiogenic shock (CS) due to left ventricular failure and is associated with increased mortality, but its impact in patients requiring temporary mechanical circulatory support (tMCS) remains unclear. We explored RVD and its association with clinical outcomes in CS patients under tMCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Individuals with CS from the SWISS Circulatory Support Registry (NCT04117230) were included. RVD was defined by \u22651 of the following parameters: tricuspid annular plane systolic excursion (TAPSE) &amp;lt; 14\u2005mm, TAPSE\/systolic pulmonary artery pressure (sPAP) &amp;lt; 0.34, right atrial pressure (RAP) &amp;gt; 15\u2005mmHg, RAP\/pulmonary capillary wedge pressure &amp;gt;0.63 or pulmonary artery pulsatility index (PAPi) &amp;lt; 1.85. The primary endpoint was 6-month mortality; secondary endpoints were hemodynamic stabilization markers. 745 patients were included: 580 supported with left-side-Impella-devices\u00a9 (with 39 requiring concomitant second device) and 165 with VA-ECMO. RVD was more prevalent in patients on VA-ECMO compared to Impella (60% vs. 33%, P &amp;lt; 0.001). In Impella patients, RVD was associated with higher 6-month mortality (43% vs. 30%, P = 0.015), higher lactate levels (1.6\u2005mmol\/L vs. 1.3\u2005mmol\/L; P = 0.01), lower central venous saturation (55% vs. 61%; P = 0.005) and reduced mean arterial pressure (55\u2005mmHg vs. 58\u2005mmHg; P = 0.002). In VA-ECMO patients with RVD, 6-month mortality was numerically higher, without statistical significance (61% vs. 45%, P = 0.13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RVD was linked to increased mortality and worse haemodynamic stabilization in patients supported with Impella, whereas this association was not demonstrated in those under VA-ECMO. RV function is a key prognostic marker in CS patients under tMCS and should be assessed to guide device selection, management, and weaning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag139","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:51:50Z","timestamp":1788954710000},"source":"Crossref","is-referenced-by-count":0,"title":["Right ventricular dysfunction in cardiogenic shock on temporary mechanical circulatory support"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7657-1788","authenticated-orcid":false,"given":"Jan","family":"Estoppey","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10 , 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6537-3915","authenticated-orcid":false,"given":"Iulia Maia","family":"Muresan","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Bern , Freiburgstrasse 3, 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1587-2819","authenticated-orcid":false,"given":"Matthias","family":"Bossard","sequence":"additional","affiliation":[{"name":"Cardiology Division, Heart Center Lucerne, Luzerner Kantonsspital , Kantonsspital 37, 6004 Lucerne ,","place":["Switzerland"]},{"name":"Faculty of Health Sciences and Medicine, Alpenquai 4, University of Lucerne , 6005 Lucerne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-5397","authenticated-orcid":false,"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel , Petersgraben 4, 4031 Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4527-5542","authenticated-orcid":false,"given":"Gregor","family":"Fahrni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Stadtspital Z\u00fcrich , Birmensdorferstrasse 497, 8063 Z\u00fcrich ,","place":["Switzerland"]},{"name":"University of Basel , Petersplatz 1, 4001 Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6290-3148","authenticated-orcid":false,"given":"Stefan","family":"Bl\u00f6chlinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10 , 3010 Bern ,","place":["Switzerland"]},{"name":"Department of Cardiology, Kantonsspital Winterthur , Brauerstrasse 15, 8400 Winterthur ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9876-3258","authenticated-orcid":false,"given":"Roger","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital , Freiburgstrasse 10, 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-9112","authenticated-orcid":false,"given":"Anna S","family":"Messmer","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital , Freiburgstrasse 10, 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"K\u00f6chli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10 , 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2075","authenticated-orcid":false,"given":"Thomas","family":"Seiler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10 , 3010 Bern ,","place":["Switzerland"]},{"name":"Cardiology Division, Heart Center Lucerne, Luzerner Kantonsspital , Kantonsspital 37, 6004 Lucerne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3771-7972","authenticated-orcid":false,"given":"Armin","family":"Spahr","sequence":"additional","affiliation":[{"name":"Cardiology Division, Heart Center Lucerne, Luzerner Kantonsspital , Kantonsspital 37, 6004 Lucerne ,","place":["Switzerland"]},{"name":"Faculty of Health Sciences and Medicine, Alpenquai 4, University of Lucerne , 6005 Lucerne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-3503","authenticated-orcid":false,"given":"Alain M","family":"Bernheim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Stadtspital Z\u00fcrich , Birmensdorferstrasse 497, 8063 Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital Winterthur , Brauerstrasse 15, 8400 Winterthur ,","place":["Switzerland"]},{"name":"Pediatric Intensive Unit, Great Ormond Street Hospital NHS Foundation Trust , London, WC1N3JH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3331-8128","authenticated-orcid":false,"given":"Florim","family":"Cuculi","sequence":"additional","affiliation":[{"name":"Cardiology Division, Heart Center 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