{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:49:25Z","timestamp":1791492565130,"version":"4.3.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"DANCAVAS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Risk stratification in infective endocarditis (IE) does not incorporate structural substrates involved in early disease initiation. The aim of this study was to examine the association between mitral annulus calcification (MAC) burden and the risk of IE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This substudy utilized the population-based DANCAVAS cohort undergoing non-contrast computed tomography (CT) with MAC quantification with follow-up until 19 August 2025. The primary outcome was incidence rates and 10-year risk of IE across three exploratory categorical groups: No MAC (0 arbitrary units (AU)), MAC 1\u2013299\u2005AU, and MAC \u2265300\u2005AU. A total of 14 793 participants were included with mean (SD) age, 66.9 (3.8) years, and 14 053 males (95.0%). Median MAC was 13\u2005AU (IQR3.3\u201356.2) in the MAC 1\u2013299 group and 680\u2005AU (IQR447\u20131271) in the MAC \u2265300 group. IE incidence rate per 10 000 person-years was 1.92 for no MAC, 2.48 for MAC 1\u2013299, and 21.3 for MAC \u2265300 (P &amp;lt; 0.001). The 10-year cumulative risk was, 0.20%(95%CI 0.12\u20130.33) for no MAC, 0.22% (95%CI 0.10\u20130.49) for MAC 1\u2013299, and 1.85% (95%CI 0.93\u20133.69) for MAC \u2265300 (P &amp;lt; 0.001). Each 100\u2005AU increase in MAC was associated with a 3% increase in the risk of IE (HR 1.03, 95%CI 1.01\u20131.05, P = 0.011). MAC \u2265300\u2005AU remained associated with IE after adjustment for established risk factors (HR 7.05, 95%CI 2.85 to 17.4, P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater MAC burden was associated with a higher risk of IE. In exploratory categorical analyses, MAC \u2265300\u2005AU was associated with the highest observed risk, although these findings should be interpreted with caution given the limited number of events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeag140","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:51:20Z","timestamp":1788616280000},"source":"Crossref","is-referenced-by-count":0,"title":["Mitral annulus calcification and the risk of infective endocarditis: insights from DANCAVAS screening trials"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-9779","authenticated-orcid":false,"given":"Lytfi","family":"Krasniqi","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital , J. B. Winsl\u00f8wsvej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Department of Clinical Research, University of Southern Denmark , Campusvej 55, Odense 5000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-4826","authenticated-orcid":false,"given":"Axel C P","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark , Campusvej 55, Odense 5000 ,","place":["Denmark"]},{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-4488","authenticated-orcid":false,"given":"Jes S","family":"Lindholt","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital , J. B. Winsl\u00f8wsvej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Department of Clinical Research, University of Southern Denmark , Campusvej 55, Odense 5000 ,","place":["Denmark"]},{"name":"Elite Centre for Individualized Medicine in Arterial Disease (CIMA), Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4210-8593","authenticated-orcid":false,"given":"Camilla","family":"Engelsgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark , Campusvej 55, Odense 5000 ,","place":["Denmark"]},{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-394X","authenticated-orcid":false,"given":"Martin","family":"Busk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vejle Hospital , Beriderbakken 4, Vejle 7100 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9796","authenticated-orcid":false,"given":"Lars","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Diagnostic Centre, Regional Hospital Silkeborg , Falkevej 1D, Silkeborg 8600 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-9981","authenticated-orcid":false,"given":"Jess","family":"Lambrechtsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , Baag\u00f8es Alle 15, Svendborg 5700 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-1256","authenticated-orcid":false,"given":"Marek","family":"Karon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nykoebing Falster Hospital , Fjordvej 15, Nykoebing Falster 4800 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-204X","authenticated-orcid":false,"given":"Jordi Sanchez","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark , Campusvej 55, Odense 5000 ,","place":["Denmark"]},{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 1st St SW, Rochester, MN 55901 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2026100816024870900_oeag140-B1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0140-6736(24)01098-5","article-title":"Infective endocarditis","volume":"404","author":"Li","year":"2024","journal-title":"Lancet"},{"key":"2026100816024870900_oeag140-B2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMcp2000400","article-title":"Native-valve infective endocarditis","volume":"383","author":"Chambers","year":"2020","journal-title":"N Engl J Med"},{"key":"2026100816024870900_oeag140-B3","doi-asserted-by":"crossref","first-page":"774224","DOI":"10.3389\/fmed.2022.774224","article-title":"The global, regional, and national burden and trends of 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