{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:29:52Z","timestamp":1777350592899,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Non-acute chest pain is a common complaint and can be caused by various conditions. With the rising healthcare expenditures of today, it is necessary to use our healthcare resources effectively. This study aims to give insight into the diagnostic effort and costs for patients with non-acute chest pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Financial data of patients without a cardiac history from four hospitals (January 2012\u2013October 2018), who were registered with the national diagnostic code \u2018no cardiac pathology\u2019 (ICD-10 Z13.6), \u2018chest wall syndrome\u2019 (ICD-10 R07.4), or \u2018stable angina pectoris\u2019 (ICD-10 I20.9) were extracted. In total, 74\u00a0091 patients were included for analysis and divided into the following final diagnosis groups: no cardiac pathology: N\u2009=\u200919\u00a0688 (age 53\u2009\u00b1\u200918), 46% male; chest wall syndrome: N\u2009=\u200940\u00a0858 (age 56\u2009\u00b1\u200915), 45% male; and stable angina pectoris (AP): N\u2009=\u200913\u00a0545 (age 67\u2009\u00b1\u200911), 61% male. A total of approximately \u20ac142.7 million was spent during diagnostic work-up. The total expenditure during diagnostic effort was \u20ac1.97, \u20ac8.13, and \u20ac10.7 million, respectively for no cardiac pathology, chest wall syndrome, and stable AP per year. After 8\u2009years of follow-up, \u226595% of the patients diagnosed with no cardiac pathology or chest wall syndrome had an (cardiac) ischaemic-free survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The diagnostic expenditure and clinical effort to ascertain non-cardiac chest pain are high. We should define what we as society find acceptable as \u2018assurance costs\u2019 with an increasing pressure on the healthcare system and costs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaa064","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:33:26Z","timestamp":1597260806000},"page":"583-590","source":"Crossref","is-referenced-by-count":17,"title":["Utilization of diagnostic resources and costs in patients with suspected cardiac chest pain"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-4427","authenticated-orcid":false,"given":"Marijke P M","family":"Vester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00eblle C","family":"Eindhoven","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , PO Box 9600, 2300 RC Leiden, The 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