{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:59:09Z","timestamp":1790744349364,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Mentored Patient-Oriented Research Career Development Award","award":["K23 HL125991"],"award-info":[{"award-number":["K23 HL125991"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL150315"],"award-info":[{"award-number":["K23HL150315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The impact of diabetes mellitus (DM) on outcomes of lower extremity revascularization (LER) for peripheral artery disease (PAD) is uncertain. We characterized associations between DM and post-procedural outcomes in PAD patients undergoing LER.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Adults undergoing surgical or endovascular LER were identified from the 2014 Nationwide Readmissions Database. DM was defined by ICD-9 diagnosis codes and sub-classified based on the presence or absence of complications (poor glycaemic control or end-organ damage). Major adverse cardiovascular and limb events (MACLEs) were defined as the composite of death, myocardial infarction, ischaemic stroke, or major limb amputation during the index hospitalization for LER. For survivors, all-cause 6-month hospital readmission was determined. Among 39\u00a0441 patients with PAD hospitalized for LER, 50.8% had DM. The composite of MACLE after LER was not different in patients with and without DM after covariate adjustment, but patients with DM were more likely to require major limb amputation [5.5% vs. 3.2%, P\u2009&amp;lt;\u20090.001; adjusted odds ratio (aOR) 1.22, 95% confidence interval (CI) 1.03\u20131.44] and hospital readmission (59.2% vs. 41.3%, P\u2009&amp;lt;\u20090.001; aOR 1.44, 95% CI 1.34\u20131.55). Of 20\u00a0039 patients with DM hospitalized for LER, 55.7% had DM with complications. These patients were more likely to have MACLE after LER (11.1% vs. 5.2%, P\u2009&amp;lt;\u20090.001; aOR 1.56 95% CI 1.28\u20131.89) and require hospital readmission (61.1% vs. 47.2%, P\u2009&amp;lt;\u20090.001; aOR 1.41 95% CI 1.27\u20131.57) than patients with uncomplicated DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>DM is present in \u224850% of patients undergoing LER for PAD and is an independent risk factor for major limb amputation and 6-month hospital readmission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaa095","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T12:57:56Z","timestamp":1608123476000},"page":"298-306","source":"Crossref","is-referenced-by-count":22,"title":["Diabetes mellitus and outcomes of lower extremity revascularization for peripheral artery disease"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-9070","authenticated-orcid":false,"given":"Nipun","family":"Bhandari","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine , 423 East 23rd Street, Room 12020-W, New York, NY 10010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Newman","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine , 423 East 23rd Street, Room 12020-W, New York, NY 10010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Berger","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine , 423 East 23rd Street, Room 12020-W, New York, NY 10010, USA"},{"name":"Department of Surgery, New York University School of Medicine , 550 1st Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel R","family":"Smilowitz","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine , 423 East 23rd Street, Room 12020-W, New York, NY 10010, USA"},{"name":"Division of Cardiology, Department of Medicine, Veterans Affairs New York Harbor Health Care System , 423 E 23rd St, New York, NY 10010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2022111813301309600_qcaa095-B1","doi-asserted-by":"crossref","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","article-title":"Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis","volume":"7","author":"Song","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2022111813301309600_qcaa095-B2","first-page":"e726","article-title":"2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease: a report of 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