{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:23:36Z","timestamp":1791944616157,"version":"4.3.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL134885"],"award-info":[{"award-number":["HL134885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mayo Clinic Foundation for Medical Education and Research"},{"name":"Paul and Ruby Tsai Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple guidelines exist for the management of aortic stenosis (AS). We systematically reviewed current guidelines and recommendations, developed by national or international medical organizations, on management of AS to aid clinical decision-making. Publications in MEDLINE and EMBASE between 1 June 2010 and 15 January 2021 were identified. Additionally, the International Guideline Library, National Guideline Clearinghouse, National Library for Health Guidelines Finder, Canadian Medical Association Clinical Practice Guidelines Infobase, and websites of relevant organizations were searched. Two reviewers independently screened titles and abstracts. Two reviewers assessed rigour of guideline development and extracted the recommendations. Of the seven guidelines and recommendations retrieved, five showed considerable rigour of development. Those rigourously developed, agreed on the definition of severe AS and diverse haemodynamic phenotypes, indications and contraindications for intervention in symptomatic severe AS, surveillance intervals in asymptomatic severe AS, and the importance of multidisciplinary teams (MDTs) and shared decision-making. Discrepancies exist in age and surgical risk cut-offs for recommending surgical aortic valve replacement (SAVR) vs. transcatheter aortic valve implantation (TAVI), the use of biomarkers and complementary multimodality imaging for decision-making in asymptomatic patients and surveillance intervals for non-severe AS. Contemporary guidelines for AS management agree on the importance of MDT involvement and shared decision-making for individualized treatment and unanimously indicate valve replacement in severe, symptomatic AS. Discrepancies exist in thresholds for age and procedural risk used in choosing between SAVR and TAVI, role of biomarkers and complementary imaging modalities to define AS severity and risk of progression in asymptomatic patients.<\/jats:p>","DOI":"10.1093\/ehjqcco\/qcab016","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T12:21:06Z","timestamp":1614774066000},"page":"340-353","source":"Crossref","is-referenced-by-count":36,"title":["Management of aortic stenosis: a systematic review of clinical practice guidelines and recommendations"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-4454","authenticated-orcid":false,"given":"Mohammed Y","family":"Khanji","sequence":"first","affiliation":[{"name":"Department of Cardiology, Newham University Hospital, Barts Health NHS Trust, Glen Road, London E13 8SL, UK"},{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London EC1A 7BE,\u00a0UK"},{"name":"NIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London EC1A 7BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, \u201cG.d\u2019Annunzio\u201d University, 66100 Chieti, Italy"},{"name":"Department of Clinical Sciences, Lund University, Jan Waldenstr\u00f6ms gata 35, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Casa di Cura Villa Serena, 65013 Citt\u00e0 Sant\u2019Angelo, Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Galusko","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital,\u00a0Denmark Hill, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baskar","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Morriston Cardiac Regional Centre, Swansea Bay Health Board,\u00a0Heol Maes Eglwys, Swansea SA6 6NL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8827","authenticated-orcid":false,"given":"C Anwar A","family":"Chahal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London EC1A 7BE,\u00a0UK"},{"name":"Department of Cardiology, University of Pennsylvania,\u00a03400 Spruce St, Philadelphia, PA 19104, USA"},{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ceriello","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, \u201cG.d\u2019Annunzio\u201d University, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Gallina","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, \u201cG.d\u2019Annunzio\u201d University, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kennon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London EC1A 7BE,\u00a0UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael I","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London EC1A 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