{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:19:49Z","timestamp":1770229189704,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Up to 40% of patients with aortic stenosis (AS) present with discordant grading of AS severity based on common transthoracic echocardiography (TTE) measures. Our aim was to evaluate the utility of TTE and multi-detector computed tomography (MDCT) measures in predicting symptomatic improvement in patients with AS undergoing transcatheter aortic valve replacement (TAVR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A retrospective review of 201 TAVR patients from January 2017 to November 2018 was performed. Pre- and post-intervention quality-of-life was measured using the Kansas City Cardiomyopathy Questionnaire (KCCQ-12). Pre-intervention measures including dimensionless index (DI), stroke volume index (SVI), mean transaortic gradient, peak transaortic velocity, indexed aortic valve area (AVA), aortic valve calcium score, and AVA based on hybrid MDCT-Doppler calculations were obtained and correlated with change in KCCQ-12 at 30-day follow-up. Among the 201 patients studied, median KCCQ-12 improved from 54.2 pre-intervention to 85.9 post-intervention. In multivariable analysis, patients with a mean gradient &amp;gt;40\u2009mmHg experienced significantly greater improvement in KCCQ-12 at follow-up than those with mean gradient \u226440\u2009mmHg (28.1 vs. 16.4, P\u2009=\u20090.015). Patients with MDCT-Doppler-calculated AVA of \u22641.2 cm2 had greater improvements in KCCQ-12 scores than those with computed tomography-measured AVA of &amp;gt;1.2 cm2 (23.4 vs. 14.1, P = 0.049) on univariate but not multivariable analysis. No association was detected between DI, SVI, peak velocity, calcium score, or AVA index and change in KCCQ-12.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Mean transaortic gradient is predictive of improvement in quality-of-life after TAVR. This measure of AS severity may warrant greater relative consideration when selecting the appropriateness of patients for TAVR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcab017","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T20:10:49Z","timestamp":1614802249000},"page":"143-149","source":"Crossref","is-referenced-by-count":4,"title":["Association between multimodality measures of aortic stenosis severity and quality-of-life improvement outcomes after transcatheter aortic valve replacement"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-6352","authenticated-orcid":false,"given":"Michael A","family":"Catalano","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahryar G","family":"Saba","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Radiology, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Rutkin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinda","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pey-Jen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra\/Northwell, 300 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"2022030200000204800_qcab017-B1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jcmg.2018.11.027","article-title":"How do we reconcile echocardiography, computed tomography, and hybrid imaging in assessing discordant grading of aortic stenosis severity?","volume":"12","author":"Delgado","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022030200000204800_qcab017-B2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jcmg.2015.01.009","article-title":"Aortic valve area calculation in aortic stenosis by CT and Doppler echocardiography","volume":"8","author":"Clavel","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022030200000204800_qcab017-B3","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/eurheartj\/ehv188","article-title":"Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data","volume":"36","author":"Kamperidis","year":"2015","journal-title":"Eur Heart J"},{"key":"2022030200000204800_qcab017-B4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCIMAGING.111.964916","article-title":"Integration of 3D imaging data in the assessment of aortic stenosis: impact on classification of disease severity","volume":"4","author":"O'Brien","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022030200000204800_qcab017-B5","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jtcvs.2011.09.075","article-title":"Aortic valve stenosis in community medical practice: determinants of outcome and implications for aortic valve replacement","volume":"144","author":"Malouf","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022030200000204800_qcab017-B6","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0735-1097(88)90286-0","article-title":"Prediction of the severity of aortic stenosis by Doppler aortic valve area determination: prospective Doppler-catheterization correlation in 100 patients","volume":"11","author":"Oh","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"2022030200000204800_qcab017-B7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.CIR.78.2.435","article-title":"Experimental validation of Doppler echocardiographic measurement of volume flow through the stenotic aortic valve","volume":"78","author":"Otto","year":"1988","journal-title":"Circulation"},{"key":"2022030200000204800_qcab017-B8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/hrt.67.2.193","article-title":"Continuity equation and Gorlin formula compared with directly observed orifice area in native and prosthetic aortic valves","volume":"67","author":"Chambers","year":"1992","journal-title":"Br Heart J"},{"key":"2022030200000204800_qcab017-B9","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1540-8175.2007.00479.x","article-title":"Demonstration of left ventricular outflow tract eccentricity by real time 3D echocardiography: implications for the determination of aortic valve area","volume":"24","author":"Doddamani","year":"2007","journal-title":"Echocardiography"},{"key":"2022030200000204800_qcab017-B10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10554-008-9362-9","article-title":"Demonstration of left ventricular outflow tract eccentricity by 64-slice multi-detector CT","volume":"25","author":"Doddamani","year":"2009","journal-title":"Int J Cardiovasc Imaging"},{"key":"2022030200000204800_qcab017-B11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.echo.2012.05.001","article-title":"Three-dimensional imaging of the left ventricular outflow tract: impact on aortic valve area estimation by the continuity equation","volume":"25","author":"Gaspar","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"key":"2022030200000204800_qcab017-B12","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0735-1097(00)00531-3","article-title":"Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure","volume":"35","author":"Green","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2022030200000204800_qcab017-B13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/jamacardio.2016.5302","article-title":"Quality-of-life outcomes after transcatheter aortic valve replacement in an unselected population: a report from the STS\/ACC transcatheter valve therapy registry","volume":"2","author":"Arnold","year":"2017","journal-title":"JAMA Cardiol"},{"key":"2022030200000204800_qcab017-B14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ahj.2017.08.006","article-title":"Durability of quality of life benefits of transcatheter aortic valve replacement: long-term results from the CoreValve US extreme risk trial","volume":"194","author":"Baron","year":"2017","journal-title":"Am Heart J"},{"key":"2022030200000204800_qcab017-B15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ahj.2004.12.010","article-title":"Monitoring clinical changes in patients with heart failure: a comparison of methods","volume":"150","author":"Spertus","year":"2005","journal-title":"Am Heart J"},{"key":"2022030200000204800_qcab017-B16","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.jacc.2014.02.537","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal - Quality of Care and Clinical Outcomes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjqcco\/advance-article-pdf\/doi\/10.1093\/ehjqcco\/qcab017\/36644112\/qcab017.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article-pdf\/8\/2\/143\/42619125\/qcab017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article-pdf\/8\/2\/143\/42619125\/qcab017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:55Z","timestamp":1646179255000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article\/8\/2\/143\/6159612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,3,5]]},"published-print":{"date-parts":[[2022,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjqcco\/qcab017","relation":{},"ISSN":["2058-5225","2058-1742"],"issn-type":[{"value":"2058-5225","type":"print"},{"value":"2058-1742","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3]]},"published":{"date-parts":[[2021,3,5]]}}}