{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:04:54Z","timestamp":1785427494745,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Utilization of transcatheter aortic valve replacement (TAVR) has expanded from high-risk patients to intermediate- and select low-risk candidates with severe aortic stenosis (AS). TAVR is currently not indicated for patients with aortic insufficiency, and its outcomes in mixed aortic valve disease (MAVD) are unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A systematic search of PubMed, Medline, CINHAL, and Cochrane databases was performed to identify studies comparing TAVR outcomes in patients with AS vs. MAVD. Primary outcomes included 30-day and late all-cause mortality, and paravalvular regurgitation (PVR). Secondary outcomes were major bleeding, vascular complications, device implantation success, permanent pacemaker, and stroke. Pooled odds ratios (OR) and 95% confidence intervals (CIs) were calculated using Der Simonian-Laird random-effects model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Six observational studies with 58 879 patients were included in the analysis. There was no significant difference in 30-day all-cause mortality [OR 1.03 (95% CI 0.92\u20131.15); P = 0.63], however, MAVD group had higher odds of moderate-to-severe PVR [1.81 (1.41\u20132.31); P &amp;lt; 0.01]. MAVD patients had lower odds of device implantation success [0.60 (0.40\u20130.91); P = 0.02] while other secondary outcomes were similar in the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>TAVR in MAVD is associated with increased odds of paravalvular regurgitation and lower odds of device implantation success when compared to severe aortic stenosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcab080","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T20:14:23Z","timestamp":1636402463000},"page":"169-176","source":"Crossref","is-referenced-by-count":14,"title":["Transcatheter aortic valve replacement in mixed aortic valve disease: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"8","author":[{"given":"Raviteja R","family":"Guddeti","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases, Creighton University School of Medicine, Omaha, NE 68154, USA"},{"name":"Division of Cardiovascular Diseases, Minneapolis Heart Institute, Minneapolis, MN 55407, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-6418","authenticated-orcid":false,"given":"Gauravpal S","family":"Gill","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Creighton University School of Medicine, Omaha, NE 68154, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M","family":"Garcia-Garcia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Georgetown University, Washington, DC 20057, USA"},{"name":"Division of Cardiovascular Medicine, MedStar Washington Hospital Center, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Mahesh","family":"Alla","sequence":"additional","affiliation":[{"name":"Division of 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