{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:20:53Z","timestamp":1787062853517,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple guidelines exist for the diagnosis and management of mitral regurgitation (MR), the second most common valvular heart disease in high-income countries, with recommendations that do not always match. We systematically reviewed guidelines on diagnosis and management of MR, highlighting similarities and differences to guide clinical decision-making. We searched national and international guidelines in MEDLINE and EMBASE (1 June 2010 to 1 September 2021), the Guidelines International Network, National Guideline Clearinghouse, National Library for Health Guidelines Finder, Canadian Medical Association Clinical Practice Guidelines Infobase, and websites of relevant organizations. Two reviewers independently screened the abstracts and identified articles of interest. Guidelines that were rigorously developed (as assessed with the Appraisal of Guidelines for Research and Evaluation II instrument) were retained for analysis.<\/jats:p>\n                  <jats:p>Five guidelines were retained. There was consensus on a multidisciplinary approach from the heart team and for the definition and grading of severe primary MR. There was general agreement on the thresholds for intervention in symptomatic and asymptomatic primary MR; however, discrepancies were present. There was agreement on optimization of medical therapy in severe secondary MR and intervention in patients symptomatic despite optimal medical therapy, but no consensus on the choice of intervention (surgical repair\/replacement vs. transcatheter approach). Cut-offs for high-risk intervention in MR, risk stratification of progressive MR, and guidance on mixed valvular disease were sparse.<\/jats:p>","DOI":"10.1093\/ehjqcco\/qcab082","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T15:14:23Z","timestamp":1636384463000},"page":"481-495","source":"Crossref","is-referenced-by-count":11,"title":["Mitral regurgitation management: a systematic review of clinical practice guidelines and recommendations"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-0900","authenticated-orcid":false,"given":"Victor","family":"Galusko","sequence":"first","affiliation":[{"name":"Department of Cardiology, King's College Hospital , London SE5 9RS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baskar","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gloucestershire Hospitals NHS Foundation Trust , Gloucester GL1 3NN , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-6623","authenticated-orcid":false,"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, G.d'Annunzio University , 66100 Chieti , Italy"},{"name":"Department of Clinical Sciences, Lund University , Jan Waldenstr\u00f6ms gata 35-205, Malm\u00f6 22100 , Sweden"},{"name":"Department of Cardiology, Casa di Cura Villa Serena , 65013 Citt\u00e0 Sant'Angelo, Pescara , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , West Smithfield, London EC1A 7BE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-5366","authenticated-orcid":false,"given":"Sanjeev","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , West Smithfield, London EC1A 7BE , UK"},{"name":"NIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London , London EC1A 7BE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mullen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , West Smithfield, London EC1A 7BE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Gallina","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, G.d'Annunzio University , 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