{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:52:13Z","timestamp":1792806733841,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/17\/81\/33 318"],"award-info":[{"award-number":["FS\/17\/81\/33 318"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014461","name":"Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We used the Multiple Cause of Death database, accessed through the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research resource. We included 629\u00a0308 decedents with cardiovascular disease (CVD) recorded as the primary cause of death and active malignancy listed as a contributing cause of death. We created disease-specific CVD categories and grouped cancers by site. We calculated the proportion of CVD deaths attributed to each disease category stratified by sex, age, and cancer site. We also examined disease-specific temporal trends by cancer site. Ischaemic heart disease (IHD) was the most common cardiovascular cause of death across all cancer types (55.6%), being more common in men (59.8%), older ages, and in those with lung (67.8%) and prostate (58.3%) cancers. Cerebrovascular disease (12.9%) and hypertensive diseases (7.6%) were other common causes of death. The proportion of deaths due to heart failure was greatest in haematological (7.7%) and breast (6.3%) cancers. There was a decreasing temporal trend in the proportion of cardiovascular deaths attributed to IHD across all cancer types. The proportion of deaths due to hypertensive diseases showed the greatest percentage increase, with the largest change in breast cancer patients (+191.1%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We demonstrate differential cardiovascular mortality risk by cancer site and demographics, providing insight into the evolving healthcare needs of this growing high-cardiovascular risk population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcac016","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:08:22Z","timestamp":1649934502000},"page":"54-63","source":"Crossref","is-referenced-by-count":43,"title":["Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-5465","authenticated-orcid":false,"given":"Zahra","family":"Raisi-Estabragh","sequence":"first","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK"},{"name":"Barts Heart Centre, St Bartholomew's Hospital , Barts Health NHS Trust, West Smithfield, London EC1A 7BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Kobo","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Hillel Yaffe Medical Center, Hadera, Israel"},{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University , Keele, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Freeman","sequence":"additional","affiliation":[{"name":"Cardiology Department, Aalborg University Hospital , Hobrovej 18-22, 9100 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen E","family":"Petersen","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK"},{"name":"Barts Heart Centre, St Bartholomew's Hospital , Barts Health NHS Trust, West Smithfield, London EC1A 7BE, UK"},{"name":"Health Data Research UK , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Kolman","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute of Alberta , Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J H","family":"Miller","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute of Alberta , Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Roguin","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Hillel Yaffe Medical Center, Hadera, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriette G C","family":"Van Spall","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact, Department of Medicine, Population Health Research Institute, Research Institute of St , Hamilton, ON, Canada"},{"name":". Joe's, McMaster University , Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Vuong","sequence":"additional","affiliation":[{"name":"UCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-7454","authenticated-orcid":false,"given":"Eric H","family":"Yang","sequence":"additional","affiliation":[{"name":"UCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University , Keele, UK"},{"name":"Department of Cardiology, Thomas Jefferson University, Philadelphia, PA, USA"},{"name":"Institute of Population Health, University of Manchester , Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"2022121310172440700_bib1","article-title":"Jointly issued by the American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the North American Association of Central Cancer Registries (NAACCR), and the National Cancer Institute","author":"Annual Report to the Nation on the Status of Cancer"},{"key":"2022121310172440700_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(19)31674-5","article-title":"Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases","volume":"394","author":"Strongman","year":"2019","journal-title":"Lancet North Am Ed"},{"key":"2022121310172440700_bib3","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","article-title":"Shared risk factors in cardiovascular disease and cancer","volume":"133","author":"Koene","year":"2016","journal-title":"Circulation"},{"key":"2022121310172440700_bib4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.arcmed.2017.03.005","article-title":"Atherosclerosis and cancer; 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