{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:51:20Z","timestamp":1768449080188,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"German Foundation of Heart Research"},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the impact on 10-year survival of patient-reported anginal status at 1 year following percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) in patients with left main coronary artery disease (LMCAD) and\/or three-vessel CAD (3VD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In this post hoc analysis of the randomized SYNTAX Extended Survival study, patients were classified as having residual angina (RA) if their self-reported Seattle Angina Questionnaire angina frequency (SAQ-AF) scale was \u226490 at the 1-year follow-up post-revascularization with PCI or CABG. The primary endpoint of all-cause death at 10 years was compared between the RA and no-RA groups. A sensitivity analysis was performed using a 6-month SAQ-AF.<\/jats:p>\n                  <jats:p>At 1 year, 373 (26.1%) out of 1428 patients reported RA. Whilst RA at 1 year was an independent correlate of repeat revascularization at 5 years [18.3\u00a0vs. 11.5%; adjusted hazard ratio (HR): 1.54; 95% confidence interval (CI): 1.10\u20132.15], it was not associated with all-cause death at 10 years (22.1\u00a0vs. 21.6%; adjusted HR: 1.11; 95% CI: 0.83\u20131.47). These results were consistent when stratified by the modality of revascularization (PCI or CABG) or by anginal frequency. The sensitivity analysis replicating the analyses based on 6-month angina status resulted in similar findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among patients with LMCAD and\/or 3VD, patient-reported RA at 1 year post-revascularization was independently associated with repeat revascularization at 5 years; however, it did not significantly increase 10-year mortality, irrespective of the primary modality of revascularization or severity of RA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcac052","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T22:28:12Z","timestamp":1661380092000},"page":"490-501","source":"Crossref","is-referenced-by-count":6,"title":["Impact of residual angina on long-term clinical outcomes after percutaneous coronary intervention or coronary artery bypass graft for complex coronary artery disease"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-5648","authenticated-orcid":false,"given":"Masafumi","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC, Academic Medical Centre, University of Amsterdam , Meibergdreef 9, Amsterdam , The Netherlands"},{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-1104","authenticated-orcid":false,"given":"Patrick W","family":"Serruys","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"},{"name":"C\u00daRAM-SFI Centre for Research in Medical Devices , Galway , Ireland"},{"name":"National Heart and Lung Institute, Imperial College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC, Academic Medical Centre, University of Amsterdam , Meibergdreef 9, Amsterdam , The Netherlands"},{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Lunardi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"},{"name":"Department of Cardiology, Radboud University , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC, Academic Medical Centre, University of Amsterdam , Meibergdreef 9, Amsterdam , The Netherlands"},{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"},{"name":"Department of Cardiology, Radboud University , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scot","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Blackburn Hospital , Blackburn , 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R","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases and Internal Medicine, Mayo Clinic , Rochester, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Morice","sequence":"additional","affiliation":[{"name":"D\u00e9partement of Cardiologie, H\u00f4pital priv\u00e9 Jacques Cartier, Ramsay G\u00e9n\u00e9rale de Sant\u00e9 Massy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie Pieter","family":"Kappetein","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus University Medical Centre , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"Noack","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Heart Centre Leipzig , Leipzig , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piroze M","family":"Davierwala","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Heart Centre Leipzig , Leipzig , Germany"},{"name":"Department of Surgery, University of Toronto , Toronto Canada"},{"name":"Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, 15 University Health Network , Toronto, Ontario , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Spertus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saint Luke's Mid America Heart Institute\/UMKC , Kansas City, Missouri , 22 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":false,"given":"David J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clinical and Outcomes Research, Cardiovascular Research Foundation, New York NY and St. Francis Hospital , Roslyn NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland, Galway (NUIG , Galway , Ireland"},{"name":") , Galway , Ireland"},{"name":"C\u00daRAM-SFI Centre for Research in Medical Devices , Galway , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the SYNTAX Extended Survival Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piroze M","family":"Davierwala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich-Wilhelm","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W J 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