{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:23Z","timestamp":1787008703472,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108015"],"award-info":[{"award-number":["82020108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871460"],"award-info":[{"award-number":["81871460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2021ZD04"],"award-info":[{"award-number":["YG2021ZD04"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["15\/RP\/2765"],"award-info":[{"award-number":["15\/RP\/2765"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate the relationship between post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) and clinical outcome using a systematic review with a study-level meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>MEDLINE, Embase, and CENTRAL were systematically searched for articles with clinical follow-up reporting mean or median final post-PCI FFR. The main outcome was a composite of major adverse cardiac events (MACE) including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). Meta-regression analyses were performed on mean post-PCI FFR values. A total of 62 studies with 12\u00a0340 patients and 12\u00a0923 stented vessels were included, with follow-ups ranging from 1 to 89 months. Post-PCI FFR was not continuously associated with the rate of 1-year MACE or 1-year TVR using meta-regression models accounting for heterogeneous follow-up lengths. For studies comparing high vs. low post-PCI FFR, low post-PCI FFR was associated with high risk ratio for MACE {1.97 [95% confidence interval (CI):1.45\u20132.67]}, all-cause death [1.59 (95% CI: 1.08\u20132.34)], MI [3.18 (95% CI: 1.84\u20135.50)], TVR [2.08 (95% CI: 1.63\u20132.65)] and angina status [2.50 (95% CI: 1.53\u20134.06)] using different optimal cut-off values spanning from 0.80 to 0.95.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found no clear continuous association between post-PCI FFR and clinical outcomes in this systematic study-level meta-analysis. In a subset of studies investigating binary classification, high post-PCI FFR was associated with a better clinical outcome than low post-PCI FFR.<\/jats:p>\n                    <jats:p>We investigated the relationship between post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) and rate of major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR), using a systematic review and study-level meta-analysis, pooling 12\u00a0340 patients from 62 studies. Mean post-PCI FFR was not continuously associated with a 1-year MACE rate accounting for heterogenous follow-up lengths. Still, the risk ratio favoured high post-PCI FFR for reduced MACE, all-cause death, MI, TVR, and better angina status using different cut-offs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcac053","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:16:12Z","timestamp":1661332572000},"page":"99-108","source":"Crossref","is-referenced-by-count":13,"title":["Predictive value of post-percutaneous coronary intervention fractional flow reserve: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"9","author":[{"given":"Birgitte Krogsgaard","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 69, 8200 Aarhus, Skejby , Denmark"},{"name":"Department of Internal Medicine, Horsens Regional Hospital , Horsens, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daixin","family":"Ding","sequence":"additional","affiliation":[{"name":"The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway , Galway , Ireland"},{"name":"Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Juul Hune","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 69, 8200 Aarhus, Skejby , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxian","family":"Tu","sequence":"additional","affiliation":[{"name":"Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Ramsing","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 69, 8200 Aarhus, Skejby , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-0844","authenticated-orcid":false,"given":"Jelmer","family":"Westra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 69, 8200 Aarhus, Skejby , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-4376","authenticated-orcid":false,"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway , Galway , 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