{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:01:46Z","timestamp":1787846506659,"version":"build-2784847793"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125004"],"award-info":[{"award-number":["82125004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Guangdong Introducing Innovative and Entrepreneurial Teams","award":["2019ZT08Y481"],"award-info":[{"award-number":["2019ZT08Y481"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["GSP-TS-6"],"award-info":[{"award-number":["GSP-TS-6"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332022125"],"award-info":[{"award-number":["3332022125"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To assess the trends in calcific aortic valve disease (CAVD) epidemiology, with an emphasis on CAVD mortality, leading risk factors, and their associations with age, period, and birth cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Prevalence, disability-adjusted life years, and mortality were derived from the Global Burden of Disease Study 2019. The age\u2013period\u2013cohort model was employed to study the detailed trends of CAVD mortality and its leading risk factors. Globally, CAVD showed unsatisfactory results from 1990 to 2019, with the CAVD deaths of 127\u00a0000 in 2019. CAVD mortality was substantially reduced in high socio-demographic index (SDI) countries [\u22121.45%, 95% confidence interval (CI) (\u22121.61 to \u22121.30)], mildly increased in high-middle SDI countries [0.22%, 95% CI (0.06\u20130.37)], and unchanged in other SDI quintiles. There was a noticeable transition in CAVD deaths from younger to older populations globally. The CAVD mortality increased exponentially with age, and the male had higher mortality than the female before 80 years old. Favourable period [0.69, 95% CI (0.66\u20130.72)] and birth effects [0.30, 95% CI (0.22\u20130.43)] were mainly observed in high SDI countries, while unfavourable effects were mostly noticed in high-middle SDI countries. High systolic blood pressure was the leading risk factor of CAVD deaths globally, and it showed favourable trends in high SDI regions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although CAVD mortality reduction was observed globally, unfavourable period, and cohort effects were found in many countries. Increase of mortality rate among the population \u226585 years was the common challenge across all SDI quintiles, stressing the necessity to further improve health care for CAVD patients worldwide.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcad018","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T22:53:24Z","timestamp":1678229604000},"page":"459-473","source":"Crossref","is-referenced-by-count":34,"title":["Alerting trends in epidemiology for calcific aortic valve disease, 1990\u20132019: An age\u2013period\u2013cohort analysis for the Global Burden of Disease Study 2019"],"prefix":"10.1093","volume":"9","author":[{"given":"Songren","family":"Shu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center , Beijing , China"},{"name":"for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"The 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Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxia","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center , Beijing , China"},{"name":"for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"The Cardiomyopathy Research Group, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center , Beijing , China"},{"name":"for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"The Cardiomyopathy Research Group, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences , Shenzhen , 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