{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:17:25Z","timestamp":1794561445984,"version":"4.9.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Philips Healthcare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Use of intravascular ultrasound (IVUS) during percutaneous coronary intervention (PCI) is associated with improved clinical outcomes over angiography alone. Despite this, the adoption of IVUS in clinical practice remains low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the cost-effectiveness of IVUS-guided PCI compared to angiography alone in patients with acute coronary syndromes (ACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A 1-year decision tree and lifetime Markov model were constructed to compare the cost-effectiveness of IVUS-guided PCI to angiography alone for two hypothetical adult populations consisting of 1000 individuals: ST-elevation myocardial infarction (STEMI) and unstable angina\/non-ST-elevation myocardial infarction (UA\/NSTEMI) patients undergoing drug-eluting stent (DES) implantation. The United Kingdom (UK) healthcare system perspective was applied using 2019\/20 costs. All-cause death, myocardial infarction (MI), repeat PCI, lifetime costs, life expectancy, and quality-adjusted life-years (QALYs) were assessed. Over a lifetime horizon, IVUS-guided PCI was cost-effective compared to angiography alone in both populations, yielding an incremental cost-effectiveness ratio of \u00a33649 and \u00a35706 per-patient in STEMI and UA\/NSTEMI patients, respectively.<\/jats:p>\n                    <jats:p>In the 1-year time horizon, the model suggested that IVUS was associated with reductions in mortality, MI, and repeat PCI by 51%, 33%, and 52% in STEMI and by 50%, 29%, and 57% in UA\/NSTEMI patients, respectively. Sensitivity analyses demonstrated the robustness of the model with IVUS being 100% cost-effective at a willingness to pay threshold of \u00a320\u00a0000 per QALY-gained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>From a UK healthcare perspective, an IVUS-guided PCI strategy was highly cost-effective over angiography alone amongst ACS patients undergoing DES implantation due to the medium- and long-term reduction in repeat PCI, death, and MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcad073","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T10:14:47Z","timestamp":1702721687000},"page":"677-688","source":"Crossref","is-referenced-by-count":20,"title":["Cost-effectiveness of intravascular ultrasound-guided percutaneous intervention in patients with acute coronary syndromes: a UK perspective"],"prefix":"10.1093","volume":"10","author":[{"given":"Andrew S P","family":"Sharp","sequence":"first","affiliation":[{"name":"University Hospital of Wales, Cardiff and Cardiff University , CF103AT","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Kinnaird","sequence":"additional","affiliation":[{"name":"University Hospital of Wales, Cardiff and Cardiff University , CF103AT","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-7829","authenticated-orcid":false,"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust and School of Medicine, University of Southampton , Southampton , SO171BJ","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruba","family":"Ayyub","sequence":"additional","affiliation":[{"name":"Deloitte , Brussels , 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