{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:15:56Z","timestamp":1777482956430,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>In patients undergoing heart valve surgery, subsequent bacteraemia and infective endocarditis (IE) are feared events. Data on the incidence and bacterial microbiological etiology following left-sided heart valve surgery are sparse.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Between 2010 and 2021, all patients undergoing left-sided valve surgery were identified using Danish nationwide registries. Incidence and type bacteraemia within 1-year post-surgery was analysed. Secondary outcome of interest was IE. Cumulative incidence curves were stratified for bacterial species and for subgroups of interest: type of valve surgery, age, and sex. A total of 14\u2009935 patients were included, of which 69% were male and the median age was 70.4 years (25th\u201375th percentile 62.4\u201376.2 years). The 1-year cumulative incidence of bacteraemia was 6.1% (95% CI 5.7\u20136.5%), and the most frequent bacteraemia was coagulase-negative staphylococci (CoNS) (27%). More than half of the bacteraemia with CoNS occurred within 30 days of follow-up. Patients developing bacteraemia had a significantly higher Charlson comorbidity score at baseline, more often underwent coronary artery bypass grafting concomitant to valve surgery, and more often had surgery on both valves. The 1-year cumulative incidence of IE was 1.5% (95% CI 1.3\u20131.7), of which 23% were caused by Enterococci, and 22% were blood culture negative. The median time from surgery to IE was 109 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Bacteraemia and infective endocarditis following left-sided heart valve surgery occurred in 6.1% and 1.5% of patients, respectively. The most frequent bacteraemia was coagulase-negative staphylococci, and more than half of these occurred within 30 days of surgery. Optimization of prophylactic strategies are warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcae080","type":"journal-article","created":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:37:06Z","timestamp":1726360626000},"page":"668-677","source":"Crossref","is-referenced-by-count":4,"title":["Bacteraemia and infective endocarditis following left-sided heart valve surgery"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5669-8889","authenticated-orcid":false,"given":"Christine","family":"Holgersson","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-1467","authenticated-orcid":false,"given":"Lauge","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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