{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:11:57Z","timestamp":1792671117120,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Individuals recovering from COVID-19 infection have reported experiencing symptoms of postural orthostatic tachycardia syndrome (POTS). These observations have raised concerns about COVID-19 as a significant precipitating factor in the development of post-viral POTS. Given the increasing number of POTS cases reported after COVID-19, we sought to examine the baseline characteristics of POTS patients before and after COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an interrupted time series analysis on data obtained from the TriNetX database, which included a cohort of 65\u2009141\u2009065 patients aged 18 and older across 64 healthcare organizations. Monthly data on incidence rates (IR), incidence cases (IC), and prevalence cases (PC) of POTS were collected from January 2018 to June 2024, with 1 March 2020 defined as the cutoff date for pre- and post-COVID analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was a significant increase in the IR of POTS post-COVID (P\u00a0&amp;lt;\u00a00.0001), with the IR increasing from 1.42\/1000\u2009000 to 20.3\/1000\u2009000 cases per person-year. Similarly, the monthly IC trend showed a significant rise from 4.21 to 22.66 cases (P\u00a0&amp;lt;\u00a00.001). The month-to-month prevalence showed an initial decline after COVID with a robust increase starting January 2023. Additionally, the prevalence of autonomic nervous system disorders and related comorbidities significantly decreased in the post-COVID cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings demonstrate a significant increase in the incidence of POTS following the COVID-19 pandemic, suggesting a potential association between COVID-19 infection and the development of post-viral POTS. Future research should explore the underlying mechanisms and treatment strategies for POTS in the context of post-COVID recovery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcae111","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T21:21:41Z","timestamp":1736284901000},"page":"698-704","source":"Crossref","is-referenced-by-count":28,"title":["Impact of COVID-19 pandemic on the incidence and prevalence of postural orthostatic tachycardia syndrome"],"prefix":"10.1093","volume":"11","author":[{"given":"Dharmindra","family":"Dulal","sequence":"first","affiliation":[{"name":"College of Medicine and Life Sciences, University of Toledo, \u00a0 Toledo, OH 43614 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-1104","authenticated-orcid":false,"given":"Ahmed","family":"Maraey","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Toledo Medical Center , 3000 Arlington Ave, Toledo, OH 43614 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeer","family":"Elsharnoby","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Toledo , Toledo, OH 43614 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chacko","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Toledo Medical Center , 3000 Arlington Ave, Toledo, OH 43614 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Grubb","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Toledo Medical Center , 3000 Arlington Ave, Toledo, OH 43614 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