{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:53:25Z","timestamp":1790999605692,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recommendations on atrial fibrillation (AF) screening by various scientific societies are inconsistent due to uncertainty about its benefit. This study aimed to summarize data from randomized controlled trials (RCTs) on the impact of AF screening on thromboembolism, major bleeding, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We searched PubMed\/MEDLINE and Embase to identify studies providing relevant data through 5 September 2024. Risk ratios (RRs) for each reported outcome of interest were pooled through a meta-analysis with random effects models. We included six RCTs reporting data from 74\u2009145 individuals. AF screening was associated with higher AF detection compared with no intervention [RR 2.54, 95% confidence interval (CI): 1.57\u20134.11, P\u00a0&amp;lt;\u00a00.001], and more common initiation of oral anticoagulation (RR 2.19, 1.51\u20133.18, P\u00a0&amp;lt;\u00a00.001). Incident ischaemic stroke (RR 0.93, 0.87\u20131.00, P\u00a0=\u00a00.048) and thromboembolism including ischaemic stroke, transient ischaemic attack, or systemic embolism (0.93, 95% CI: 0.87\u20130.99, P\u00a0=\u00a00.026) were less frequent in individuals who underwent AF screening vs. controls. There was no difference for major bleeding, (RR 0.99, 95% CI: 0.93\u20131.06, P\u00a0=\u00a00.830), haemorrhagic stroke (RR 0.94, 95% CI: 0.80\u20131.11, P\u00a0=\u00a00.497) and all-cause mortality (RR 0.99, 95% CI: 0.95\u20131.02, P\u00a0=\u00a00.411).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AF screening might be beneficial, especially in reducing thromboembolic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcae114","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T23:16:47Z","timestamp":1735946207000},"page":"282-290","source":"Crossref","is-referenced-by-count":8,"title":["Atrial fibrillation screening and clinical outcomes: a meta-analysis of randomized controlled trials"],"prefix":"10.1093","volume":"11","author":[{"given":"Ulrich Flore","family":"Nyaga","sequence":"first","affiliation":[{"name":"Health Data Acumen , Nairobi 22003-00400 ,","place":["Kenya"]},{"name":"Edea Regional Hospital Department of Medicine, , Edea 100 ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kamtchum-Tatuene","sequence":"additional","affiliation":[{"name":"University of Oxford Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, , Oxford OX14 3GA ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Nouthe","sequence":"additional","affiliation":[{"name":"University of British Columbia Department of Medicine, , Vancouver V5Z 1M9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-6712","authenticated-orcid":false,"given":"Clovis","family":"Nkoke","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Buea Department of Internal Medicine, , Buea 63 ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-9757","authenticated-orcid":false,"given":"Jean Jacques","family":"Noubiap","sequence":"additional","affiliation":[{"name":"University of California-San Francisco Division of Cardiology, Department of Medicine, , San Francisco CA 94143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"2025050111120383000_bib1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.jacc.2024.07.014","article-title":"Minimum national prevalence of diagnosed atrial fibrillation inferred from California Acute Care facilities","volume":"84","author":"Noubiap","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2025050111120383000_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000506396","article-title":"Global, regional and country-specific burden of ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage: a systematic analysis of the Global Burden of Disease Study 2017","volume":"54","author":"Krishnamurthi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"2025050111120383000_bib3","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1016\/j.jacc.2019.10.040","article-title":"Ischemic stroke risk in patients with nonvalvular atrial fibrillation: JACC review topic of the week","volume":"74","author":"Alkhouli","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025050111120383000_bib4","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1161\/01.STR.27.10.1765","article-title":"Acute stroke with atrial fibrillation. 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