{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:30:53Z","timestamp":1790188253864,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["NET-2016-02363853"],"award-info":[{"award-number":["NET-2016-02363853"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","award":["H43D24000050007"],"award-info":[{"award-number":["H43D24000050007"]}],"id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare adherence to perindopril\/amlodipine\/atorvastatin combination administrated as a polypill (one pill) vs. separate tablets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using the healthcare utilization database of Lombardy (Italy), 1110 patients who received the perindopril\/amlodipine\/atorvastatin polypill during 2019\u20132021 were matched with 1110 patients prescribed the same combination in separate tablets or as two antihypertensive drugs in a single tablet and the lipid-lowering drug tablet separately. Adherence to treatment was assessed over the year after the first perindopril\/amlodipine\/atorvastatin dispensation as the proportion of the follow-up days covered by prescription (PDC). Patients with a PDC &amp;gt;75% and &amp;lt;25% were defined as highly and poorly adherent, respectively. Adherence dynamics over time were evaluated through group-based trajectory modelling. Cardiovascular-related healthcare costs were also assessed. Log-binomial regression models were fitted to estimate the risk ratio (RR) of treatment adherence associated with the administration strategy. Among the polypill and the separate-pill combination users, 60% and 18% of patients showed high adherence, respectively; the corresponding figures for the low adherence were 5% and 37%. Compared with the separate-pill combination, the polypill increased the propensity to be highly adherent to treatment by 3.29 times (95% confidence interval: 2.88\u20133.75) and reduced the low adherence risk (RR\u00a0=\u00a00.13, 0.10\u20130.18), irrespective of sex, age, comorbidities, and co-treatment burden also throughout the entire follow-up. The polypill was also associated with lower costs (\u20ac676 vs. \u20ac1068, P\u00a0=\u00a00.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a real-life setting, the polypill improved treatment adherence and reduced healthcare costs compared to the corresponding separate-pill combination. These findings support current guidelines in favour of the polypill.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcae116","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:15:39Z","timestamp":1735888539000},"page":"1301-1309","source":"Crossref","is-referenced-by-count":4,"title":["Adherence to perindopril\/amlodipine\/atorvastatin combination according to the administration strategy"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-2081","authenticated-orcid":false,"given":"Gabriella","family":"Morabito","sequence":"first","affiliation":[{"name":"National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca , 20126 Milan ,","place":["Italy"]},{"name":"Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca , 20126 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-5101","authenticated-orcid":false,"given":"Federico","family":"Rea","sequence":"additional","affiliation":[{"name":"National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca , 20126 Milan ,","place":["Italy"]},{"name":"Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca , 20126 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-8444","authenticated-orcid":false,"given":"Giovanni","family":"Corrao","sequence":"additional","affiliation":[{"name":"University of Milano-Bicocca (Emeritus Professor), Department of Statistics and Quantitative Methods , 20126 Milan 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