{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:26Z","timestamp":1792785866949,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z141100002114050"],"award-info":[{"award-number":["Z141100002114050"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L232117"],"award-info":[{"award-number":["L232117"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170309"],"award-info":[{"award-number":["82170309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Military Health Care","award":["17BJZ08"],"award-info":[{"award-number":["17BJZ08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify comorbidity patterns in elderly Chinese patients with atrial fibrillation (AF), their clinical course, and the effectiveness of the Atrial fibrillation Better Care (ABC) pathway adherence among these phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From the ChiOTEAF Registry, we performed a latent class analysis based on 16 cardiovascular (CV) and non-CV conditions. The association between classes of patients, management, and outcomes was evaluated. The primary outcome was a composite of all-cause death and major adverse CV events. We assessed the impact of ABC adherence on outcomes in the whole cohort and among phenotypes. We included 4765 AF patients [median age 77 (68\u201383) years, 39.1% females]. Four phenotypes were identified: (i) low complexity (48.9%); (ii) atherosclerotic (19.3%); (iii) heart failure (19.4%); and (iv) high complexity (12.3%). During a 1-year follow-up, compared to the \u2018low complexity\u2019 class, the risk of adverse events was higher in \u2018high complexity\u2019 [aOR, 95% confidence interval (CI): 3.20, 2.21\u20134.66] and \u2018heart failure\u2019 classes (aOR, 95% CI: 1.50, 1.04\u20132.17). Among 2654 patients [median age 75 (66\u201381) years, 43.3% females] with available information to assess the ABC pathway, 1094 (41.2%) were adherent. ABC pathway adherence was associated with a lower risk of adverse events (aOR, 95% CI: 0.37, 0.20\u20130.65). On interaction analysis, its beneficial effect was similar across different clinical phenotypes (Pint\u00a0=\u00a00.122).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Different clinical phenotypes can be identified in Asian AF patients, with specific patterns of comorbidities and different risks of adverse events. Full ABC pathway adherence was associated with improved outcomes, regardless of the clinical phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaf014","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:28:49Z","timestamp":1744702129000},"page":"981-992","source":"Crossref","is-referenced-by-count":8,"title":["Patterns of comorbidities, clinical course, and impact of the ABC Pathway for Integrated Care in patients with atrial fibrillation: a report from the prospective Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) Registry"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7290-5361","authenticated-orcid":false,"given":"Marta","family":"Mantovani","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool, L7 8TX ,","place":["UK"]},{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena , Modena 41125 ,","place":["Italy"]},{"name":"Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia , Modena 41125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-6234","authenticated-orcid":false,"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool, L7 8TX ,","place":["UK"]},{"name":"Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo F","family":"Imberti","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool, L7 8TX ,","place":["UK"]},{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena , Modena 41125 ,","place":["Italy"]},{"name":"Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia , Modena 41125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H M","family":"Lam","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool, L7 8TX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-3187","authenticated-orcid":false,"given":"Agnieszka","family":"Babinska","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Silesian Center for Heart Diseases , 41-800 Zabrze ,","place":["Poland"]},{"name":"Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia , 40-055 Katowice ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4815","authenticated-orcid":false,"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena , Modena 41125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-7751","authenticated-orcid":false,"given":"Yutao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Vessel and Thrombotic Disease, Sixth Medical Centre, Chinese PLA General Hospital , Beijing 100853 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool, L7 8TX ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ChiOTEAF Registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taixiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congchun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuntai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang","family":"Aiming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gexin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Yutao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou","family":"Cuihong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zaoguang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyi","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Meilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yanxia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Zhiming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Xuejun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhaoliang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Xiangming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Lijuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiefu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"2025110923203201300_bib1","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1055\/s-0042-1756355","article-title":"Clinical complexity domains, anticoagulation, and outcomes in patients with atrial fibrillation: a report from the GLORIA-AF Registry phase II and III","volume":"122","author":"Romiti","year":"2022","journal-title":"Thromb Haemost"},{"key":"2025110923203201300_bib2","doi-asserted-by":"publisher","first-page":"f329","DOI":"10.1093\/europace\/eux322","article-title":"Multimorbidity and co-morbidity in atrial fibrillation and effects on survival: findings from UK Biobank cohort","volume":"20","author":"Jani","year":"2018","journal-title":"Europace"},{"key":"2025110923203201300_bib3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s42444-023-00086-2","article-title":"Managing high-risk atrial fibrillation patients with multiple comorbidities","volume":"24","author":"Lip","year":"2023","journal-title":"Int J Arrhythm"},{"key":"2025110923203201300_bib4","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.mayocp.2019.06.012","article-title":"Long-term relationship between atrial fibrillation, multimorbidity and oral anticoagulant drug use","volume":"94","author":"Proietti","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"2025110923203201300_bib5","doi-asserted-by":"publisher","first-page":"111482","DOI":"10.1016\/j.exger.2021.111482","article-title":"Relationship between multimorbidity and outcomes in atrial fibrillation","volume":"153","author":"Proietti","year":"2021","journal-title":"Exp Gerontol"},{"key":"2025110923203201300_bib6","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3390\/jcm11051370","article-title":"Impact of multimorbidity and polypharmacy on clinical outcomes of elderly Chinese patients with atrial fibrillation","volume":"11","author":"Kotalczyk","year":"2022","journal-title":"J Clin Med"},{"key":"2025110923203201300_bib7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrcardio.2017.153","article-title":"The ABC pathway: an integrated approach to improve AF management","volume":"14","author":"Lip","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2025110923203201300_bib8","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jacc.2020.01.052","article-title":"Mobile health technology to improve care for patients with atrial fibrillation","volume":"75","author":"Guo","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2025110923203201300_bib9","doi-asserted-by":"publisher","first-page":"e2140071","DOI":"10.1001\/jamanetworkopen.2021.40071","article-title":"The effects of implementing a mobile health-technology supported pathway on atrial fibrillation-related adverse events among patients with multimorbidity: the mAFA-II randomized clinical trial","volume":"4","author":"Yao","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2025110923203201300_bib10","doi-asserted-by":"publisher","first-page":"101757","DOI":"10.1016\/j.eclinm.2022.101757","article-title":"Adherence to the Atrial Fibrillation Better Care (ABC) pathway and the risk of major outcomes in patients with atrial fibrillation: a post-hoc analysis from the prospective GLORIA-AF Registry","volume":"55","author":"Romiti","year":"2023","journal-title":"EClinicalMedicine"},{"key":"2025110923203201300_bib11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1093\/europace\/euaa274","article-title":"Relation of outcomes to ABC (Atrial Fibrillation Better Care) pathway adherent care in European patients with atrial fibrillation: an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) Registry","volume":"23","author":"Proietti","year":"2021","journal-title":"Europace"},{"key":"2025110923203201300_bib12","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s12916-022-02526-7","article-title":"Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry","volume":"20","author":"Romiti","year":"2022","journal-title":"BMC Med"},{"key":"2025110923203201300_bib13","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.jacasi.2022.01.007","article-title":"Atrial fibrillation better care pathway adherent care improves outcomes in Chinese patients with Atrial fibrillation","volume":"2","author":"Guo","year":"2022","journal-title":"JACC Asia"},{"key":"2025110923203201300_bib14","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1055\/s-0043-1769612","article-title":"Mobile Health-Technology-integrated Care for Atrial fibrillation: a win ratio analysis from the mAFA-II randomized clinical trial","volume":"123","author":"Romiti","year":"2023","journal-title":"Thromb Haemost"},{"key":"2025110923203201300_bib15","doi-asserted-by":"publisher","first-page":"e13751","DOI":"10.1111\/eci.13751","article-title":"4S-AF scheme and ABC pathway guided management improves outcomes in atrial fibrillation patients","volume":"52","author":"Guo","year":"2022","journal-title":"Eur J Clin Invest"},{"key":"2025110923203201300_bib16","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"2025110923203201300_bib17","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"2025110923203201300_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-0041-1739411","article-title":"2021 Focused update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke prevention in Atrial Fibrillation: executive summary","volume":"122","author":"Chao","year":"2022","journal-title":"Thromb Haemost"},{"key":"2025110923203201300_bib19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1055\/a-2325-5923","article-title":"2024 Chinese expert consensus guidelines on the diagnosis and treatment of atrial fibrillation in the elderly, endorsed by Geriatric Society of Chinese Medical Association (Cardiovascular Group) and Chinese Society of Geriatric Health Medicine (Cardiovascular Branch): executive summary","volume":"124","author":"Wang","year":"2024","journal-title":"Thromb Haemost"},{"key":"2025110923203201300_bib20","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad226","article-title":"Atrial fibrillation and stroke prevention: 25 years of research at EP Europace journal","volume":"25","author":"Lip","year":"2023","journal-title":"Europace"},{"key":"2025110923203201300_bib21","doi-asserted-by":"publisher","first-page":"102703","DOI":"10.1016\/j.eclinm.2024.102703","article-title":"Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts","volume":"74","author":"Krauth","year":"2024","journal-title":"EClinicalMedicine"},{"key":"2025110923203201300_bib22","doi-asserted-by":"publisher","first-page":"e0169426","DOI":"10.1371\/journal.pone.0169426","article-title":"A latent class analysis of multimorbidity and the relationship to socio-demographic factors and health-related quality of life. A national population-based study of 162,283 Danish adults","volume":"12","author":"Larsen","year":"2017","journal-title":"PLoS One"},{"key":"2025110923203201300_bib23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12916-024-03373-4","article-title":"Patterns of comorbidities in patients with atrial fibrillation and impact on management and long-term prognosis: an analysis from the Prospective Global GLORIA-AF Registry","volume":"22","author":"Romiti","year":"2024","journal-title":"BMC Med"},{"key":"2025110923203201300_bib24","doi-asserted-by":"publisher","first-page":"101752","DOI":"10.1016\/j.cpcardiol.2023.101752","article-title":"Features of clinical complexity in European patients with atrial fibrillation: a report from a European observational prospective AF registry","volume":"48","author":"Proietti","year":"2023","journal-title":"Curr Probl Cardiol"},{"key":"2025110923203201300_bib25","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1093\/ehjqcco\/qcab057","article-title":"Quality indicators in the management of elderly Chinese patients with atrial fibrillation: a report from the Optimal Thromboprophylaxis in elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry","volume":"8","author":"Guo","year":"2022","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"2025110923203201300_bib26","doi-asserted-by":"publisher","first-page":"e020191","DOI":"10.1136\/bmjopen-2017-020191","article-title":"Optimal thromboprophylaxis in elderly Chinese patients with Atrial fibrillation (ChiOTEAF) registry: protocol for a prospective, observational nationwide cohort study","volume":"8","author":"Guo","year":"2018","journal-title":"BMJ Open"},{"key":"2025110923203201300_bib27","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1002\/joa3.12608","article-title":"One-year follow-up results of the optimal thromboprophylaxis in elderly Chinese patients with atrial fibrillation (ChiOTEAF) registry","volume":"37","author":"Guo","year":"2021","journal-title":"J Arrhythm"},{"key":"2025110923203201300_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/CBO9780511499531.004","article-title":"Latent class cluster analysis","volume-title":"Applied Latent Class Analysis","author":"Vermunt","year":"2002"},{"key":"2025110923203201300_bib29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"2025110923203201300_bib30","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"2025110923203201300_bib31","doi-asserted-by":"publisher","first-page":"100967","DOI":"10.1016\/j.lanepe.2024.100967","article-title":"Comparing CHA","volume":"43","author":"Teppo","year":"2024","journal-title":"Lancet Reg Health Eur"},{"key":"2025110923203201300_bib32","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/europace\/eut395","article-title":"The European Heart Rhythm Association symptom classification for atrial fibrillation: validation and improvement through a simple modification","volume":"16","author":"Wynn","year":"2014","journal-title":"Europace"},{"key":"2025110923203201300_bib33","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"efinition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"2025110923203201300_bib34","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0140-6736(13)61752-3","article-title":"The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective","volume":"383","author":"Mahmood","year":"2014","journal-title":"Lancet"},{"key":"2025110923203201300_bib35","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1136\/heartjnl-2023-322447","article-title":"Phenotyping of atrial fibrillation with cluster analysis and external validation","volume":"109","author":"Saito","year":"2023","journal-title":"Heart"},{"key":"2025110923203201300_bib36","first-page":"100883","article-title":"Identifying risk patterns in older adults with atrial fibrillation by hierarchical cluster analysis: a retrospective approach based on the risk probability for clinical events","volume":"37","author":"Suzuki","year":"2021","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2025110923203201300_bib37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/CIRCULATIONAHA.123.068576","article-title":"\u201cAsian\u201d heart failure","volume-title":"Circulation","author":"Yoo","year":"2024"},{"key":"2025110923203201300_bib38","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jacasi.2024.01.013","article-title":"Epidemiology and burden of heart failure in Asia","volume":"4","author":"Feng","year":"2024","journal-title":"JACC Asia"},{"key":"2025110923203201300_bib39","doi-asserted-by":"publisher","first-page":"e032785","DOI":"10.1161\/JAHA.123.032785","article-title":"Risk of death and cardiovascular events in Asian patients with atrial fibrillation and chronic obstructive pulmonary disease: a report from the prospective APHRS registry","volume":"13","author":"Bucci","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2025110923203201300_bib40","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/biomedicines9070843","article-title":"Clinical phenotype classification of atrial fibrillation patients using cluster analysis and associations with trial-adjudicated outcomes","volume":"9","author":"Vitolo","year":"2021","journal-title":"Biomedicines"},{"key":"2025110923203201300_bib41","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12916-021-02120-3","article-title":"Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry","volume":"19","author":"Proietti","year":"2021","journal-title":"BMC Med"},{"key":"2025110923203201300_bib42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/ehjqcco\/qcaa070","article-title":"Treatment of older patients with atrial fibrillation by morbidity burden","volume":"8","author":"Rasmussen","year":"2022","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"2025110923203201300_bib43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/ageing\/afx103","article-title":"Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-regression analysis","volume":"47","author":"Bai","year":"2018","journal-title":"Age Ageing"},{"key":"2025110923203201300_bib44","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/ageing\/afv156","article-title":"Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial","volume":"45","author":"Ng","year":"2016","journal-title":"Age Ageing"},{"key":"2025110923203201300_bib45","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1161\/STROKEAHA.116.012988","article-title":"Current status and time trends of oral anticoagulation use among Chinese patients with nonvalvular atrial fibrillation: the Chinese atrial fibrillation Registry study","volume":"47","author":"Chang","year":"2016","journal-title":"Stroke"},{"key":"2025110923203201300_bib46","doi-asserted-by":"publisher","first-page":"102039","DOI":"10.1016\/j.eclinm.2023.102039","article-title":"Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry","volume":"63","author":"Romiti","year":"2023","journal-title":"EClinicalMedicine"},{"key":"2025110923203201300_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad244","article-title":"Progress in atrial fibrillation ablation during 25 years of Eurospace journal","volume":"25","author":"Boersma","year":"2023","journal-title":"Europace"},{"key":"2025110923203201300_bib48","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae043","article-title":"2024 European Heart Rhythm Association\/Heart Rhythm Society\/Asia Pacific Heart Rhythm Society\/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"26","author":"Tzeis","year":"2024","journal-title":"Europace"},{"key":"2025110923203201300_bib49","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1093\/europace\/euac173","article-title":"Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials","volume":"25","author":"Simader","year":"2023","journal-title":"Europace"},{"key":"2025110923203201300_bib50","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter ablation for atrial fibrillation with heart failure","volume":"378","author":"Marrouche","year":"2018","journal-title":"N Engl J Med"},{"key":"2025110923203201300_bib51","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1161\/CIRCULATIONAHA.122.060274","article-title":"Early rhythm control in patients with atrial fibrillation and high comorbidity burden","volume":"146","author":"Rillig","year":"2022","journal-title":"Circulation"},{"key":"2025110923203201300_bib52","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1055\/a-1807-0336","article-title":"Early rhythm control and the risks of ischemic stroke, heart failure, mortality, and adverse events when performed Early (&lt;3 Months): a nationwide cohort study of newly diagnosed patients with atrial fibrillation","volume":"122","author":"Chao","year":"2022","journal-title":"Thromb Haemost"},{"key":"2025110923203201300_bib53","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.108.821306","article-title":"Atrial fibrillation and heart failure: treatment considerations for a dual epidemic","volume":"119","author":"Anter","year":"2009","journal-title":"Circulation"},{"key":"2025110923203201300_bib54","article-title":"The 2024 ESC Guidelines for diagnosis and management of AF: a clinicians' perspective","volume":"124","author":"Potpara","year":"2024","journal-title":"ThrombHaemost"},{"key":"2025110923203201300_bib55","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.jacasi.2023.04.008","article-title":"Integrated care for atrial fibrillation using the ABC pathway in the prospective APHRS-AF registry","volume":"3","author":"Bucci","year":"2023","journal-title":"JACC Asia"}],"container-title":["European Heart Journal - Quality of Care and Clinical Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjqcco\/advance-article-pdf\/doi\/10.1093\/ehjqcco\/qcaf014\/62934235\/qcaf014.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article-pdf\/11\/7\/981\/62934235\/qcaf014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article-pdf\/11\/7\/981\/62934235\/qcaf014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T04:20:38Z","timestamp":1762748438000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article\/11\/7\/981\/8113972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":55,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4,15]]},"published-print":{"date-parts":[[2025,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjqcco\/qcaf014","relation":{},"ISSN":["2058-5225","2058-1742"],"issn-type":[{"value":"2058-5225","type":"print"},{"value":"2058-1742","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,4,15]]}}}