{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:28Z","timestamp":1792512928099,"version":"4.5.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The impact of sex-related differences on outcomes following transcatheter aortic valve replacement (TAVR) remains inconclusive. This study investigates sex-related differences in survival and safety outcomes in patients with aortic stenosis undergoing TAVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We systematically searched PubMed, Embase, Scopus, and Cochrane Library until November 2024. Individual patient data (IPD) were reconstructed from published Kaplan\u2013Meier curves and compared using Cox-proportional hazards model for overall survival and cardiovascular mortality. Pooled risk ratios (RR) for safety outcomes at 30-days and 1 year were estimated using a random-effects model. A total of 48 studies (69 355 women and 65 580 men) were included. Meta-analysis of reconstructed IPD showed that men were at higher risk of all-cause mortality at 5 years [hazard ratio (HR): 1.24, 95% confidence interval (CI): 1.20\u20131.28, P &amp;lt; 0.001] and cardiovascular mortality at 4 years (HR: 1.34, 95% CI: 1.21\u20131.49, P &amp;lt; 0.001) compared with women. In random-effects meta-analysis, men faced a higher risk of permanent pacemaker implantation (RR: 1.29, 95% CI: 1.16\u20131.44, P &amp;lt; 0.001) during the first year. Men experienced a lower risk of stroke (RR: 0.75, 95% CI: 0.64\u20130.87, P &amp;lt; 0.001) and major vascular complications (RR: 0.58, 95% CI: 0.49\u20130.69, P &amp;lt; 0.001) at 30 days, and a lower risk of major bleeding (RR: 0.77, 95% CI: 0.70\u20130.84, P &amp;lt; 0.001) as well as major vascular complications (RR: 0.54, 95% CI: 0.43\u20130.68, P &amp;lt; 0.001) within the first year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Men demonstrated poorer 5-year overall survival and 4-year cardiovascular survival following TAVR compared with women. Future research with extended follow-up is needed to understand the mechanism underlying sex-specific TAVR outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaf022","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:58:35Z","timestamp":1745319515000},"page":"642-653","source":"Crossref","is-referenced-by-count":11,"title":["Sex-related differences in survival and safety outcomes after transcatheter aortic valve replacement: a meta-analysis of reconstructed time-to-event data"],"prefix":"10.1093","volume":"11","author":[{"given":"Kiarash","family":"Tavakoli","sequence":"first","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin Sadat","family":"Hosseini Mohammadi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Fallahtafti","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima Shamshiri","family":"Khamene","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4615-9380","authenticated-orcid":false,"given":"Maryam","family":"Taheri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cardiology Research Center, Hamadan University of Medical Sciences , Hamadan ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Accident and Emergency Department (A&E), Royal Hampshire County Hospital , Winchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Bahiraie","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Karimi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mobin","family":"Alishahi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Islamic Azad University, Tehran Medical Branch , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Pazoki","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Anaraki","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-0858","authenticated-orcid":false,"given":"Sina","family":"Kazemian","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramtin","family":"Khanipour","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, HCA Florida Bayonet Point Hospital, University of South Florida , Hudson, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar K","family":"Khalique","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital & Heart Center , Roslyn, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Thomas","family":"May","sequence":"additional","affiliation":[{"name":"Intermountain Heart Institute, Intermountain Medical Center , Murray, UT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy","family":"Thachil","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Elmhurst Hospital\/Mount Sinai College of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina H","family":"Iskander","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Medical College of Wisconsin , Milwaukee, WI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Waheed","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Pennsylvania State University , Hershey, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-3099","authenticated-orcid":false,"given":"Kaveh","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Karegar Ave , Tehran 1411713138 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"2025081218294445200_qcaf022-B1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J Am Coll 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