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In a nationwide TAVI registry, we assessed the proportion of patients experiencing either a deterioration in quality of life (QoL) or death 1 year after TAVI, and the factors associated with these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This prospective substudy of the FRANCE TAVI registry included patients enrolled between 2018 and 2019 who completed the EuroQoL-5-dimension-5-level (EQ-5D-5L) questionnaire at baseline and 1 year. Among the 3159 patients (median age 83 years), EQ-5D-5L visual analogue scale increased significantly from 60 (IQR 50\u201370) at baseline to 70 (IQR 50\u201380) at follow-up (P &amp;lt; 0.001). However, 459 patients (14.5%) experienced a deterioration in QoL, and 596 (18.9%) died within 1 year. According to a multivariable logistic model, factors significantly associated with poor outcome were frailty [OR 1.40, 95% confidence interval (CI) (1.08\u20131.83)], diabetes [OR 1.41, 95% CI (1.06\u20131.88)], chronic pulmonary disease [OR 1.55, 95% CI (1.09\u20132.20)], critical pre-operative status [OR 0.42, 95% CI (0.21\u20130.83)], left ventricular ejection fraction [OR 1.01, 95% CI (1.00\u20131.02)], mean aortic gradient at discharge [OR 0.97, 95% CI (0.95\u20131.00)], need for pacemaker implantation [OR 1.51, 95% CI (1.10\u20132.06)], anticoagulation therapy at discharge [OR 1.65, 95% CI (1.23\u20132.22)], and time to discharge [OR 1.04, 95% CI (1.01\u20131.07)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although TAVI improved overall QoL, 14.5% of patients experienced a deterioration in QoL and 18.9% died within 1 year. Predictors included baseline comorbidities and post-procedural factors (anticoagulation at discharge and time to discharge), which are largely unpredictable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaf041","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T07:48:55Z","timestamp":1749887335000},"page":"12-24","source":"Crossref","is-referenced-by-count":5,"title":["Poor outcome after transcatheter aortic valve implantation using the EuroQoL-5-dimension-5-level: insights from the FRANCE TAVI registry"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-1528","authenticated-orcid":false,"given":"Gaspard","family":"Suc","sequence":"first","affiliation":[{"name":"Cardiology Department, Bichat Hospital, APHP, LVTS U1148 INSERM , 46 rue Henri Huchard, 75018 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Boureau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHU Rouen , Rouen F-76000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-7959","authenticated-orcid":false,"given":"Eric","family":"Durand","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Univ Rouen Normandie, INSERM U1096, CHU Rouen , Rouen F-76000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-4793","authenticated-orcid":false,"given":"Hakim","family":"Benamer","sequence":"additional","affiliation":[{"name":"ICPS Jacques Cartier, Groupe Ramsay G\u00e9n\u00e9rale de Sant\u00e9, Massy. 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