{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:22:00Z","timestamp":1793395320585,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Impact of sex-related differences on clinical outcomes after tricuspid transcatheter edge-to-edge repair (T-TEER) for severe tricuspid regurgitation (TR) remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This sub-analysis of the Transcatheter tRicuspid valve repaIr in SPAin (TRI-SPA) registry includes patients who underwent T-TEER for severe TR between June 2020 and May 2023 in Spain. Outcomes were compared by sex. The primary composite endpoint included all-cause mortality, heart failure-related hospitalization, and tricuspid valve re-intervention at 12\u2005months. Secondary endpoints included significant TR recurrence and functional improvement. Among 310 patients (mean age 75.5 \u00b1 9.1\u2005years) with severe TR treated with T-TEER, 70% were females. Males exhibited more prevalent coronary artery disease (30.4 vs. 12.8%; p &amp;lt; 0.001) and reduced right ventricular (RV) function compared with females (RV fractional area change 34.5 vs. 42.0%; p &amp;lt; 0.001). Women had larger left atrial volume (45.7 vs. 40.8\u2005mL\/m\u00b2, p = 0.038). Procedural success was high and comparable among sexes (90.7 vs. 89.3% in females and males, respectively; p = 0.71). No significant difference emerged in relation to the primary composite endpoint (absolute event rate in males 27.5 vs. 16.3% in females; adjusted HR 0.61, 95% CI: 0.31\u20131.18; p = 0.142). At 12\u2005months, comparable sustained TR reduction (grade \u22642+) rates (67.3% in males vs. 73.5% in females; p = 0.40) and functional improvement (NYHA I\/II class 75.0 vs. 82.3%; p = 0.78) were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a real-world setting, T-TEER was equally safe and effective in both sexes, achieving comparable procedural success and durable TR reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaf097","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:43:48Z","timestamp":1756295028000},"page":"68-79","source":"Crossref","is-referenced-by-count":3,"title":["Tricuspid transcatheter edge-to-edge repair for tricuspid valve regurgitation: a sex-based real-world analysis from the TRI-SPA registry"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-5398","authenticated-orcid":false,"given":"Andrea","family":"Ruberti","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Hospital Cli\u0301nic , 08036 Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cepas-Guillen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Hospital Cli\u0301nic , 08036 Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-6875","authenticated-orcid":false,"given":"Julio","family":"Echarte-Morales","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Alvaro Cunqueiro , 36316 Vigo ,","place":["Spain"]},{"name":"Cardiovascular Research Group, Department of Cardiology, University Hospital Alvaro Cunqueiro, Fundaci\u00f3n Biom\u00e9dica Galicia Sur, Servizo Galego de Saude, University of Vigo , 36312 Vigo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-5867","authenticated-orcid":false,"given":"Dabit","family":"Arzamendi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute (IIB Sant Pau), Universitat Aut\u00f2noma de Barcelona , 08025 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Mo\u00f1ivas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Puerta de Hierro-Majadahonda , 28222 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Carrasco-Chinchilla","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica del Coraz\u00f3n, Hospital Universitario Virgen de la Victoria , 29010 M\u00e1laga ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-9051","authenticated-orcid":false,"given":"Manuel","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Reina Sofi\u0301a, Universidad de Co\u0301rdoba, Instituto Maimo\u0301nides de Investigacio\u0301n Biome\u0301dica de Co\u0301rdoba (IMIBIC), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , 14004 Co\u0301rdoba ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-8907","authenticated-orcid":false,"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Hospital Cl\u00ednico San Carlos, IdISSC , 28040 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-1364","authenticated-orcid":false,"given":"Isaac","family":"Pascual","sequence":"additional","affiliation":[{"name":"Heart Area, Hospital Universitario Central de Asturias , 33011 Oviedo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-3705","authenticated-orcid":false,"given":"Manel","family":"Sabat\u00e8-Tenas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Hospital Cli\u0301nic , 08036 Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-9248","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Benito-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Le\u00f3n , 24008 Le\u00f3n ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital , 15006 A Coru\u00f1a ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"G\u00f3mez-Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital 12 Octubre , 28041 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-4129","authenticated-orcid":false,"given":"Ignacio J","family":"Amat-Santos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic Hospital, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares , 47010 Valladolid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Flores-Umanzor","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Hospital Cli\u0301nic , 08036 Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Cruz-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de Salamanca, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca , 37007 Salamanca 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Biom\u00e9dica Galicia Sur, Servizo Galego de Saude, University of Vigo , 36312 Vigo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Hospital Cli\u0301nic , 08036 Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS) , 08036 Barcelona ,","place":["Spain"]},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona (UB) , 08036 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hion","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute (IIB Sant Pau), Universitat Aut\u00f2noma de Barcelona , 08025 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Caneiro-Queija","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Alvaro Cunqueiro , 36316 Vigo ,","place":["Spain"]},{"name":"Cardiovascular Research Group, Department of Cardiology, University Hospital Alvaro Cunqueiro, Fundaci\u00f3n Biom\u00e9dica Galicia Sur, Servizo Galego de Saude, University of Vigo , 36312 Vigo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Trigo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Puerta de Hierro-Majadahonda , 28222 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 David","family":"Mart\u00ednez-Carmona","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica del Coraz\u00f3n, Hospital Universitario Virgen de la 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