{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:10:44Z","timestamp":1772727044164,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000090","name":"Department of Defense Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["PR171210"],"award-info":[{"award-number":["PR171210"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Department of Defense Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH-18-1-0725"],"award-info":[{"award-number":["W81XWH-18-1-0725"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The impact of menopausal hormone therapy (HT), and its timing on cardiovascular disease (CVD) remains controversial in women. The aim of the study is to examine the association of HT with incident CVD in women veterans (WV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Veterans Health Administration (VHA) electronic records were used to identify WV aged \u226545 years who engaged with VHA from 1\/1\/2000-12\/31\/2017. HT was defined as any oral or transdermal oestrogen-containing product or combined oestrogen\u2013progestin. Incident CVD was defined as new-onset ischaemic heart disease (IHD), stroke, heart failure (HF), atrial fibrillation\/flutter (AF), aortic stenosis (AS), pulmonary hypertension (PHTN), venous thromboembolism (VTE), and peripheral arterial disease (PAD). Propensity score matching was used to match WV with and without HT on demographics, CVD risk factors, mental health conditions, and cardiovascular medication use. Cox proportional hazards models were used to estimate hazard ratios. Stratified analyses were conducted across distinct age categories. A total of 241 943 WV met the inclusion criteria, including 9295 with HT. After 1:2 propensity score matching, the HT cohort had significantly higher rates of CVD compared to the non-HT cohort (22.4% vs. 11.7%, P &amp;lt; 0.001), and all-cause mortality (8.0% vs. 5.2%, P &amp;lt; 0.001). In the Cox proportional hazards regression model, HT was independently associated with a greater risk of CVD (HR = 1.74, 95% CI: 1.63\u20131.85), Death (HR = 1.25 95% CI: 1.13\u20131.39), and IHD, stroke, HF, AF, AS, PHTN, PAD, and VTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that menopausal HT is associated with increased risk of a broad range of CVD and death in WV 45 years and older.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaf136","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:11:42Z","timestamp":1762647102000},"page":"261-270","source":"Crossref","is-referenced-by-count":1,"title":["Association of menopausal hormone therapy with incident cardiovascular disease in women veterans"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-8371","authenticated-orcid":false,"given":"Lingyu","family":"Xu","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislau","family":"Hrybouski","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuancheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Baoan District Central Hospital of Shenzhen , Shenzhen, Guangdong 518100 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-1339","authenticated-orcid":false,"given":"Ramin","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiology Section, Greater Los Angeles VA Healthcare System , 11301 Wilshire Blvd, Los Angeles, CA 90073 ,","place":["USA"]},{"name":"Department of Medicine, Cardiology Section, University of California Los Angeles , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"2026030502063502500_qcaf136-B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1161\/CIR.0000000000001303","article-title":"2025 Heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"2026030502063502500_qcaf136-B2","doi-asserted-by":"publisher","first-page":"e506","DOI":"10.1161\/CIR.0000000000000912","article-title":"Menopause transition and cardiovascular disease risk: implications for timing of early prevention: a scientific statement from the American Heart Association","volume":"142","author":"El Khoudary","year":"2020","journal-title":"Circulation"},{"key":"2026030502063502500_qcaf136-B3","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3390\/medicina55090602","article-title":"The controversial history of hormone replacement therapy","volume":"55","author":"Cagnacci","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"2026030502063502500_qcaf136-B4","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1001\/jama.279.9.688","article-title":"Estrogen therapy in postmenopausal women: effects on cognitive function and dementia","volume":"279","author":"Yaffe","year":"1998","journal-title":"JAMA"},{"key":"2026030502063502500_qcaf136-B5","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. 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