{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:42:27Z","timestamp":1789753347499,"version":"4.0.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100019718","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014091","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020604","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020604","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Early diagnosis of heart failure (HF) remains challenging, as symptoms are often nonspecific or absent. We aimed to evaluate the performance of a two-step screening strategy combining a symptom-based questionnaire\u2014based on the acronym EPOF (dyspnoea, weight gain, oedema, fatigue in French)\u2014and capillary NT-proBNP fingerstick testing to identify individuals with elevated cardiovascular risk or preclinical HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We screened 2481 adults without known HF during a nationwide, community-based campaign held in 21 hospital cardiology centres across France. All participants underwent capillary NT-proBNP testing using a point-of-care assay. A threshold of &amp;gt;125\u2005pg\/mL, per European Society of Cardiology guidelines for ruling out HF in ambulatory settings, was exceeded in 419 individuals (16.9%), of whom 36.5% were asymptomatic. Conversely, 30.5% of those with NT-proBNP \u2264125\u2005pg\/mL reported at least one symptom.<\/jats:p>\n                    <jats:p>Symptom-based screening alone had limited diagnostic accuracy for detecting NT-proBNP &amp;gt;125\u2005pg\/mL. The presence of \u22651 symptom yielded a sensitivity of 63.2% and a specificity of 42.4%. Dyspnoea was the most sensitive symptom (47.7%), while weight gain had the highest specificity (84.7%). In contrast, the absence of both symptoms and NT-proBNP elevation was associated with a high negative predictive value (85.4%).<\/jats:p>\n                    <jats:p>Among the 198 participants with NT-proBNP &amp;gt;125\u2005pg\/mL who underwent cardiologist-led evaluation, 40.9% were classified as symptomatic HF (Stage C) and 24.2% as preclinical HF (Stage B).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining symptom assessment with NT-proBNP testing improves early identification of at-risk individuals and may help uncover a significant proportion of undiagnosed or early-stage HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaf164","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:26:10Z","timestamp":1767443170000},"page":"468-476","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of a combined symptom-based questionnaire and capillary natriuretic peptides testing for early detection of heart failure: a Heart Failure Awareness Days nationwide screening study (DEPIC FR)"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-3110","authenticated-orcid":false,"given":"Emmanuelle","family":"Berthelot","sequence":"first","affiliation":[{"name":"Cardiology Department, H\u00f4pital Bic\u00eatre, AP-HP , 78 rue du G\u00e9n\u00e9ral Leclerc, Le Kremlin-Bic\u00eatre 94270 ,","place":["France"]},{"name":"Faculty of Medicine, Universit\u00e9 Paris-Saclay , 94270 Le Kremlin-Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-8129","authenticated-orcid":false,"given":"Nathan","family":"Mewton","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie des Hospices Civils de Lyon, Universit\u00e9 Claude Bernard, 69500 Lyon 1 (Bron) ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-9687","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"Cardiology Department, INI-CRT, CHU de Montpellier, PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS , Montpellier 34295 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Logeart","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lariboisi\u00e8re, AP-HP , 75010 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mansencal","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ambroise Par\u00e9, AP-HP, Centre de r\u00e9f\u00e9rence des cardiomyopathies, UVSQ, INSERM U1018 , 92100 Boulogne-Billancourt ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Jagu","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint-Joseph , 75014 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-C\u00e9line","family":"Martin","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure Unit, Cardiology Department, AP-HP European Hospital Georges Pompidou, Universit\u00e9 Paris Cit\u00e9, INSERM_1140 , Paris F-75015 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Legrand","sequence":"additional","affiliation":[{"name":"H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Fauvel","sequence":"additional","affiliation":[{"name":"H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, INSERM U1096, Univ Rouen Normandie, CHU Rouen , Rouen ,","place":["France"]},{"name":"CHU de Rennes, 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-0887","authenticated-orcid":false,"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-962X","authenticated-orcid":false,"given":"Amina","family":"Rakisheva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Qonaev City Hospital , Qonaev 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Transplantation Cardiaque, Service de Cardiologie, CHU de Toulouse, H\u00f4pital Rangueil , 1 avenue du Pr Jean-Poulh\u00e8s, TSA 50032, Toulouse Cedex 9 31059 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Canoui Poitrine","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lairez","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Insuffisance Cardiaque, Assistance et Transplantation Cardiaque, Service de Cardiologie, CHU de Toulouse, H\u00f4pital Rangueil , 1 avenue du Pr Jean-Poulh\u00e8s, TSA 50032, Toulouse Cedex 9 31059 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Tarti\u00e8re","sequence":"additional","affiliation":[{"name":"CHITS, Department of Cardiology, H\u00f4pital Sainte-Musse , Toulon 83100 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A clinical consensus statement of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"25","author":"Docherty","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"2026062310165544900_qcaf164-B4","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2026062310165544900_qcaf164-B5","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ejhf.1494","article-title":"Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations","volume":"21","author":"Mueller","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026062310165544900_qcaf164-B6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/14737159.2023.2216386","article-title":"An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure","volume":"23","author":"N\u00fa\u00f1ez-Mar\u00edn","year":"2023","journal-title":"Expert Rev Mol Diagn"},{"key":"2026062310165544900_qcaf164-B7","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/ejhf.2848","article-title":"Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society","volume":"25","author":"Tsutsui","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"2026062310165544900_qcaf164-B8","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/ejhf.2950","article-title":"Unlocking the potential of natriuretic peptide testing in primary care: a roadmap for early heart failure diagnosis","volume":"25","author":"Bayes-Genis","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"2026062310165544900_qcaf164-B9","article-title":"Validation of a novel point-of-care testing device designed for assessment of NT-pro BNP","volume":"7","author":"Larsson","year":"2023","journal-title":"Fam Med Prim Care Open Access"},{"key":"2026062310165544900_qcaf164-B10","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/ehf2.14390","article-title":"Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score","volume":"10","author":"Ofstad","year":"2023","journal-title":"ESC Heart Fail"},{"key":"2026062310165544900_qcaf164-B11","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/eurheartj\/ehaf034","article-title":"Suspected de novo heart failure in outpatient care: the REVOLUTION HF study","volume":"46","author":"Anderson","year":"2025","journal-title":"Eur Heart J"},{"key":"2026062310165544900_qcaf164-B12","doi-asserted-by":"crossref","DOI":"10.38125\/OAJBS.000339","article-title":"A comparison of capillary versus venous n-terminal prohormone brain natriuretic peptide","volume":"4","author":"Mh","year":"2021","journal-title":"Open Access J Biomed Sci"},{"key":"2026062310165544900_qcaf164-B13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.jacc.2013.05.069","article-title":"PONTIAC (NT-proBNP Selected PreventiOn of cardiac eveNts in a populaTion of dIabetic patients without a history of cardiac disease)","volume":"62","author":"Huelsmann","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026062310165544900_qcaf164-B14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jama.2013.7588","article-title":"Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF randomized trial","volume":"310","author":"Ledwidge","year":"2013","journal-title":"JAMA"},{"key":"2026062310165544900_qcaf164-B15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/eurjhf\/hft019","article-title":"Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy","volume":"15","author":"Gulati","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026062310165544900_qcaf164-B16","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jacc.2005.08.077","article-title":"Prediction of cardiovascular outcomes with left atrial size: is volume superior to area or diameter?","volume":"47","author":"Tsang","year":"2006","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal - 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