{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:30:10Z","timestamp":1786433410774,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100018430","name":"Fondazione Istituto Europeo di Oncologia e Centro Cardiologico Monzino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018430","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["B43C24000090001"],"award-info":[{"award-number":["B43C24000090001"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiopulmonary exercise testing (CPET) is the gold standard for assessing exertional dyspnoea, providing peak oxygen uptake (VO2), and the VE\/VCO2 slope. Different metabolic carts, may introduce systematic variability, confounding longitudinal assessments and multicentre trials.<\/jats:p>\n                    <jats:p>We evaluated intra-device reliability and inter-device comparability of CPET parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this prospective, single-centre, within-subject, repeated-measures, multi-device comparison study 34 healthy adults (35 \u00b1 11 years; 59% males) completed eight CPETs: two per cart, on four systems (MGC Ultima\u2122 CPX, COSMED Quark CPET\u2122, Schiller PowerCube\u00ae Ergo, Vyaire Vyntus\u2122 CPX). Tests used randomized order, ramp protocols on cycle ergometer, and standardized calibration, masks, and timing (2\u201310 days apart; within 40 days). Breath by breath data were 10-second averaged. Analyses included paired tests for intra-device reliability, repeated-measures ANOVA for inter-device comparisons, and iso-workload evaluation at 25\u2013100% of lowest peak workload (ISO-Wpeak). Intra-device reliability was high, with no significant differences in VO2, heart rate or workload at anaerobic threshold (AT), respiratory compensation point (RCP) or peak. Minor variances occurred in resting VO2 (COSMED: 56\u2005mL\/min, P = 0.0427) and peak ventilation (Medical Graphic 9\u2005L\/min, P &amp;lt; 0.05). Inter-device comparability showed no differences in peak VO2 and the VE\/VCO2 slope calculated up to the RCP. The VE\/VCO2 slope assessed as the full slope however, showed significant differences between machines (P = 0.0048). Across standardized ISO-Wpeak (25%, 50%, 75%, and 100% of ISO-Wpeak), VO2 values were largely comparable between devices, with significant differences only for VO2 (mL\/kg\/min) at 25% ISO-Wpeak (P = 0.022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Under standardized conditions, the tested metabolic carts yield comparable values both for intra-device reliability and inter-device comparability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcag036","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:41:20Z","timestamp":1772714480000},"page":"753-764","source":"Crossref","is-referenced-by-count":1,"title":["Method validation of cardiopulmonary exercise testing: intra- and inter-device comparisons across four metabolic 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