{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:28:12Z","timestamp":1790962092855,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Johnson & Johnson Pharmaceutical Research and Development"},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/ehjqcco\/qcy040","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T15:11:53Z","timestamp":1536765113000},"page":"145-152","source":"Crossref","is-referenced-by-count":110,"title":["Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF"],"prefix":"10.1093","volume":"5","author":[{"given":"Sean T","family":"Chen","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Department of Medicine, 2400 Pratt St, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne S","family":"Hellkamp","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Department of Medicine, 2400 Pratt St, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Health and Diseases, University of Cincinnati College of Medicine, 3590 Lucille Drive Suite 2700, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Thrombosis and Hemostasis Group, Bayer U.S. LLC, 11 Waterview Blvd., Parsippany, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Breithardt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of M\u00fcnster, Albert-Schweitzer-Campus 1, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A A","family":"Fox","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh and Royal Infirmary of Edinburgh, 51 Little France Cres, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Hacke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ruprecht-Karls-University, Im Neuenheimer Feld 672, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L","family":"Halperin","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Mount Sinai Medical Center, 1190 Fifth Avenue - 1 West, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J","family":"Hankey","sequence":"additional","affiliation":[{"name":"The University of Western Australia, School of Medicine and Pharmacology, 35 Stirling Highway Perth WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C","family":"Nessel","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC, 1000 US-202, Raritan, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Department of Medicine, 2400 Pratt St, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manesh R","family":"Patel","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Department of Medicine, 2400 Pratt St, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Melloni","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Department of Medicine, 2400 Pratt St, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B3","doi-asserted-by":"crossref","first-page":"e102861.","DOI":"10.1371\/journal.pone.0102861","article-title":"Atrial fibrillation as a marker of occult cancer","volume":"9","author":"Ostenfeld","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B4","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/europace\/eup300","article-title":"Introducing a new entity: chemotherapy-induced arrhythmia","volume":"11","author":"Guglin","year":"2009","journal-title":"Europace"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.athoracsur.2010.03.100","article-title":"Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons General Thoracic Surgery Database","volume":"90","author":"Onaitis","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B6","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.amjcard.2015.01.540","article-title":"Relation between cancer and atrial fibrillation (from the REasons for Geographic And Racial Differences in Stroke Study)","volume":"115","author":"O'Neal","year":"2015","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9343(02)01029-X","article-title":"Colorectal cancer and atrial fibrillation: a case-control study","volume":"112","author":"Guzzetti","year":"2002","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B8","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jacc.2013.11.026","article-title":"Insights into onco-cardiology: atrial fibrillation in cancer","volume":"63","author":"Farmakis","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B9","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archinte.160.6.809","article-title":"Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study","volume":"160","author":"Heit","year":"2000","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ijcard.2015.10.166","article-title":"Bleeding risk and major adverse events in patients with cancer on oral anticoagulation therapy","volume":"203","author":"Lee","year":"2016","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ahj.2009.11.025","article-title":". Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study","volume":"159","year":"2010","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/2047487318759858","article-title":"CHA2DS2-VASc score and risk of thromboembolism and bleeding in patients with atrial fibrillation and recent cancer","volume":"25","author":"D\u2019Souza","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ehjqcco\/qcx004","article-title":"Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry","volume":"3","author":"Melloni","year":"2017","journal-title":"Eur Hear J Qual Care Clin Outcomes"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B15","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.amjmed.2017.06.026","article-title":"Efficacy and safety of apixaban versus warfarin in patients with atrial fibrillation and a history of cancer: insights from the ARISTOTLE trial","volume":"130","author":"Melloni","year":"2017","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B16","doi-asserted-by":"crossref","first-page":"325.","DOI":"10.1016\/S0735-1097(17)33714-2","article-title":"Efficacy and safety of edoxaban in patients with active malignancy and atrial fibrillation: analysis of the ENGAGE AF-TIMI 48 Trial","volume":"69","author":"Fanola","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijcard.2018.07.138","article-title":"Patients with cancer and atrial fibrillation treated with DOACs: a prospective cohort study","volume":"269","author":"Vedovati","year":"2018","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jacc.2017.06.047","article-title":"Risk of arterial thromboembolism in patients with cancer","volume":"70","author":"Navi","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B19","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jacc.2014.05.065","article-title":"Laboratory measurement of the anticoagulant activity of the non-vitamin K oral anticoagulants","volume":"64","author":"Cuker","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B20","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.jacc.2013.02.058","article-title":"The P-glycoprotein transport system and cardiovascular drugs","volume":"61","author":"Wessler","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1634\/theoncologist.2013-0239","article-title":"New oral anticoagulants and the cancer patient","volume":"19","author":"Short","year":"2014","journal-title":"Oncologist"},{"key":"key\n\t\t\t\t2019032909594732700_qcy040-B22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1182\/bloodadvances.2017010694","article-title":"Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation","volume":"2","author":"Shah","year":"2018","journal-title":"Blood Adv"}],"container-title":["European Heart Journal - Quality of Care and Clinical Outcomes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjqcco\/article-pdf\/5\/2\/145\/28245729\/qcy040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T10:00:02Z","timestamp":1553853602000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjqcco\/article\/5\/2\/145\/5097870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,9,14]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjqcco\/qcy040","relation":{},"ISSN":["2058-5225","2058-1742"],"issn-type":[{"value":"2058-5225","type":"print"},{"value":"2058-1742","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2018,9,14]]}}}