{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:40:37Z","timestamp":1775936437712,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["NIH R01-013422"],"award-info":[{"award-number":["NIH R01-013422"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Center for Advancing Translational Sciences Colorado Clinical and Translational Science Awards","award":["UL1 TR001082"],"award-info":[{"award-number":["UL1 TR001082"]}]},{"name":"Veterans Affairs Health Services Research and Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with heart failure often have under-recognized symptoms, depression, anxiety, and poorer spiritual well-being (\u2018QoL domains\u2019). Ideally all patients should have heart failure-specific health status and quality of life (QoL) domains routinely evaluated; however, lack of time and resources are limiting in most clinical settings. Therefore, we aimed to evaluate whether heart failure-specific health status was associated with QoL domains and to identify a score warranting further evaluation of QoL domain deficits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Participants (N\u2009=\u2009314) enrolled in the Collaborative Care to Alleviate Symptoms and Adjust to Illness trial completed measures of heart failure-specific health status [Kansas City Cardiomyopathy Questionnaire, KCCQ (score 0\u2013100, 0\u2009=\u2009worst health status)], additional symptoms (Memorial Symptom Assessment Scale), depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), and spiritual well-being (Facit-Sp) at baseline. Mean \u00b1 standard deviation (SD) KCCQ score was 46.9\u2009\u00b1\u200919.3, mean age was 65.5 \u00b1 11.4, and 79% were male. Prevalence of QoL domain deficits ranged from 11% (nausea) to 47% (depression). Sensitivity\/specificity of KCCQ for each QoL domain ranged from 20\u201340%\/80\u201396% for KCCQ\u2009\u2264\u200925, 61\u201384%\/48\u201362% for KCCQ\u2009\u2264\u200950, 84\u201397%\/26\u201340% for KCCQ\u2009\u2264\u200960, and 96\u2013100%\/8\u201313% for KCCQ\u2009\u2264\u200975. Patients with KCCQ\u2009\u2264\u200960 had mean \u00b1 SD 4.5\u2009\u00b1\u20092.5 QoL domain deficits (maximum 12), vs. 1.6\u2009\u00b1\u20091.6 for KCCQ\u2009&gt;\u200960 (P\u2009&lt;\u20090.001). Similar results were seen for KCCQ \u226425 (6.6\u2009\u00b1\u20092.4 vs. 3.3\u2009\u00b1\u20092.4), KCCQ\u2009\u2264\u200950 (4.8\u2009\u00b1\u20092.6 vs. 2.5\u2009\u00b1\u20092) and KCCQ\u2009\u2264\u200975 (4.0\u2009\u00b1\u20092.6 vs. 1.0\u2009\u00b1\u20091.2) (all P\u2009&lt;\u200900001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>KCCQ\u2009\u2264\u200960 had good sensitivity for each QoL domain deficit and for patients with at least one QoL domain deficit. Screening for QoL domain deficits should target patients with lower KCCQ scores based on a clinic\u2019s KCCQ score distribution and clinical resources for addressing QoL domain deficits.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcy061","type":"journal-article","created":{"date-parts":[[2018,12,29]],"date-time":"2018-12-29T15:08:17Z","timestamp":1546096097000},"page":"233-241","source":"Crossref","is-referenced-by-count":19,"title":["Does heart failure-specific health status identify patients with bothersome symptoms, depression, anxiety, and\/or poorer spiritual well-being?"],"prefix":"10.1093","volume":"5","author":[{"given":"Kelsey M","family":"Flint","sequence":"first","affiliation":[{"name":"Rocky Mountain Regional VA Medical Center, Cardiology, Department of Medicine, 1700 North Wheeling Street, Aurora, CO, USA"},{"name":"Colorado Cardiovascular Outcomes Research Consortium, 13199 E Montview Blvd, Suite 300, Mail Stop F443, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane L","family":"Fairclough","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Informatics, Colorado School of Public Health, 13199 E Montview Blvd, Suite 339, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute, University of Missouri-Kansas City, 4401 Wornall Rd, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B","family":"Bekelman","sequence":"additional","affiliation":[{"name":"Colorado Cardiovascular Outcomes Research Consortium, 13199 E Montview Blvd, Suite 300, Mail Stop F443, Denver, CO, USA"},{"name":"Rocky Mountain Regional VA Medical Center, Palliative Care, Department of Medicine, 1700 North Wheeling Street, Aurora, CO, USA"},{"name":"Division of General Internal Medicine, Department of 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