{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:24:01Z","timestamp":1761578641445,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been shown to reduce angina and improve quality of life, but the frequency of new or residual angina after CTO PCI and its relationship with titration of anti-anginal medications (AAMs) has not been described.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Among consecutive CTO PCI patients treated at 12 US centres in the OPEN CTO registry, angina was assessed 6\u2009months after the index PCI using the Seattle Angina Questionnaire (SAQ) Angina Frequency scale (a score &lt;100 defined new or residual angina). We then compared the proportion of patients with AAM escalation (defined as an increase in the number or dosage of AAMs between discharge and follow-up) between those with and without 6-month angina. Of 901 patients who underwent CTO PCI, 197 (21.9%) reported angina at 6-months, of whom 80 (40.6%) had de-escalation, 66 (33.5%) had no change, and only 51 (25.9%) had escalation of their AAM by the 6-month follow-up. Rates of AAM escalation were similar when stratifying patients by the ultimate success of the CTO PCI, completeness of physiologic revascularization, presence or absence of angina at baseline, history of heart failure, and by degree of symptomatic improvement after CTO PCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>One in five patients reported angina 6\u2009months after CTO PCI. Although patients with new or residual angina were more likely to have escalation of AAMs in follow-up compared with those without residual symptoms, only one in four patients with residual angina had escalation of AAMs. Although it is unclear whether this finding reflects maximal tolerated therapy at baseline or therapeutic inertia, these findings suggest an important potential opportunity to further improve symptom control in patients with complex stable ischaemic heart disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcz015","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T20:43:59Z","timestamp":1552941839000},"page":"370-379","source":"Crossref","is-referenced-by-count":4,"title":["Anti-anginal medication titration among patients with residual angina 6-months after chronic total occlusion percutaneous coronary intervention: insights from OPEN CTO registry"],"prefix":"10.1093","volume":"5","author":[{"given":"Justin P","family":"Sheehy","sequence":"first","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Qintar","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne V","family":"Arnold","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Hirai","sequence":"additional","affiliation":[{"name":"Section of Cardiology, University of Chicago Medical Center, 924 East 57th Street, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Sapontis","sequence":"additional","affiliation":[{"name":"Monash Heart, Cardiovascular Research Centre, Monash Medical Centre, 246 Clayton Road, Clayton Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G","family":"Jones","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitiri","family":"Karmpaliotis","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Presbyterian Hospital, 161 Fort Washington Ave, New York, NY, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W","family":"Moses","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Presbyterian Hospital, 161 Fort Washington Ave, New York, NY, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Patterson","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit P","family":"Amin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Washington University in Saint Louis, 660 S Euclid Ave, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, York Hospital, 1001 S George St, York, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Spertus","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Aaron","family":"Grantham","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam C","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Missouri-Kansas City, 2464 Charlotte St., Kansas City, MO, USA"},{"name":"Saint Luke\u2019s Mid America Heart Institute, 4401 Wornall Road, CV Research 9th floor, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"2019100309220180900_qcz015-B1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jcin.2017.05.065","article-title":"Early procedural and health status outcomes after chronic total occlusion angioplasty: a report from the OPEN-CTO registry (outcomes, patient health status, and efficiency in chronic total occlusion hybrid procedures)","volume":"10","author":"Sapontis","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"2019100309220180900_qcz015-B2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jacc.2011.12.007","article-title":"Current perspectives on coronary chronic total occlusions: the Canadian Multicenter Chronic Total Occlusions 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