{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:35:14Z","timestamp":1785461714787,"version":"3.56.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T00:00:00Z","timestamp":1589068800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union\u2019s HORIZON 2020 Programme","award":["643597"],"award-info":[{"award-number":["643597"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p\/>\n                  <jats:p>Decellularized aortic homografts (DAH) may provide an additional aortic valve replacement option for young patients due to their potential to overcome the high early failure rate of conventional allogenic and xenogenic aortic valve prostheses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A prospective, European Union-funded, single-arm, multicentre, safety study was conducted in 8 centres evaluating non-cryopreserved DAH for aortic valve replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>One hundred and forty-four patients (99 male) were prospectively enrolled between October 2015 and October 2018, mean age 33.6\u2009\u00b1\u200920.8 years; 45% had undergone previous cardiac operations. Mean implanted DAH diameter 22.6\u2009\u00b1\u20092.4\u2009mm and mean durations for the operation, cardiopulmonary bypass and cross-clamp were 341\u2009\u00b1\u2009140, 174\u2009\u00b1\u200980 and 126\u2009\u00b1\u200943\u2009min, respectively. There were 2 early deaths (1 LCA thrombus on day 3 and 1 ventricular arrhythmia 5\u2009h postop) and 1 late death due to endocarditis 4 months postoperatively, resulting in a total mortality of 2.08%. One pacemaker implantation was necessary and 1 DAH was successfully repaired after 6 weeks for early regurgitation following subcoronary implantation. All other DAH were implanted as a free-standing root. After a mean follow-up of 1.54\u2009\u00b1\u20090.81 years, the primary efficacy end points peak gradient (mean 11.8\u2009\u00b1\u20097.5\u2009mmHg) and regurgitation (mean 0.42\u2009\u00b1\u20090.49, grade 0\u20133) were excellent. At 2.5 years, freedom from explantation\/endocarditis\/bleeding\/stroke was 98.4\u2009\u00b1\u20091.1%\/99.4\u2009\u00b1\u20090.6%\/99.1\u2009\u00b1\u20090.9%\/99.2\u2009\u00b1\u20090.8%, respectively, with results almost identical to those in an age-matched Ross operation cohort of 212 patients (mean age 34 years) despite DAH patients having undergone &amp;gt;2\u00d7 more previous procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The initial results of the prospective multicentre ARISE trial show DAH to be safe for aortic valve replacement with excellent haemodynamics in the short follow-up period.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaa100","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:19:24Z","timestamp":1583497164000},"page":"1045-1053","source":"Crossref","is-referenced-by-count":42,"title":["Early results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement: the ARISE study and ARISE Registry data"],"prefix":"10.1093","volume":"58","author":[{"given":"Alexander","family":"Horke","sequence":"first","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-110X","authenticated-orcid":false,"given":"G\u00fcnther","family":"Laufer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-5432","authenticated-orcid":false,"given":"Martin","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Pomar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital Clinico de Barcelona, Barcelona, Spain"},{"name":"Department of Cardiology, Hospital Clinico de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-8722","authenticated-orcid":false,"given":"Daniel","family":"Pereda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital Clinico de Barcelona, Barcelona, Spain"},{"name":"Department of Cardiology, Hospital Clinico de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital Clinico de Barcelona, Barcelona, Spain"},{"name":"Department of Cardiology, Hospital Clinico de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-4732","authenticated-orcid":false,"given":"Marta","family":"Sitges","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital Clinico de Barcelona, Barcelona, Spain"},{"name":"Department of Cardiology, Hospital Clinico de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-2302","authenticated-orcid":false,"given":"Filip","family":"Rega","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-5007","authenticated-orcid":false,"given":"Mark","family":"Hazekamp","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"H\u00fcbler","sequence":"additional","affiliation":[{"name":"Division of Congenital Cardiovascular Surgery, University Children\u2019s Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schmiady","sequence":"additional","affiliation":[{"name":"Division of Congenital Cardiovascular Surgery, University Children\u2019s Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Rosendahl","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Lichtenberg","sequence":"additional","affiliation":[{"name":"Department for Cardiovascular Surgery, Heinrich-Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-8678","authenticated-orcid":false,"given":"Payam","family":"Akhyari","sequence":"additional","affiliation":[{"name":"Department for Cardiovascular Surgery, Heinrich-Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadan","family":"Jashari","sequence":"additional","affiliation":[{"name":"European Homograft Bank, Clinique Saint-Jean, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Boethig","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Bobylev","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Avsar","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serghei","family":"Cebotari","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Haverich","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-7597","authenticated-orcid":false,"given":"Samir","family":"Sarikouch","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"2020102110251626400_ezaa100-B1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/CIRCULATIONAHA.118.037187","article-title":"Aortic valve replacement with bovine pericardial tissue valve in children and young adults","volume":"139","author":"Saleeb","year":"2019","journal-title":"Circulation"},{"key":"2020102110251626400_ezaa100-B2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jtcvs.2019.03.094","article-title":"Current evidence for prosthesis selection: what can we really say?","volume":"158","author":"Chiu","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtcvs.2017.08.121","article-title":"Bioprosthetic aortic valve replacement: revisiting prosthesis choice in patients younger than 50 years old","volume":"155","author":"Schnittman","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B4","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1093\/eurheartj\/ehx199","article-title":"Mechanical aortic valve replacement in non-elderly adults: meta-analysis and microsimulation","volume":"38","author":"Korteland","year":"2017","journal-title":"Eur Heart J"},{"key":"2020102110251626400_ezaa100-B5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1055\/s-0038-1676816","article-title":"Antiplatelet therapy versus anticoagulation after surgical bioprosthetic aortic valve replacement: a systematic review and meta-analysis","volume":"119","author":"An","year":"2019","journal-title":"Thromb Haemost"},{"key":"2020102110251626400_ezaa100-B6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jtcvs.2018.07.014","article-title":"The Ross procedure: time to reevaluate the guidelines","volume":"157","author":"Misfeld","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B7","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jtcvs.2014.06.025","article-title":"Homograft use in reoperative aortic root and proximal aortic surgery for endocarditis: a 12-year experience in high-risk patients","volume":"148","author":"Preventza","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B8","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.athoracsur.2012.12.027","article-title":"Aortic valve and ascending aorta guidelines for management and quality measures: executive summary","volume":"95","author":"Svensson","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"2020102110251626400_ezaa100-B9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ejcts\/ezw013","article-title":"Decellularized aortic homografts for aortic valve and aorta ascendens replacement","volume":"50","author":"Tudorache","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020102110251626400_ezaa100-B10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1089\/ten.tea.2013.0316","article-title":"Early systemic cellular immune response in children and young adults receiving decellularized fresh allografts for pulmonary valve replacement","volume":"20","author":"Neumann","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"2020102110251626400_ezaa100-B11","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jtcvs.2016.03.050","article-title":"Late durability of decellularized allografts for aortic valve replacement: a word of caution","volume":"152","author":"Helder","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B12","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jtcvs.2017.01.046","article-title":"Every like is not the same","volume":"153","author":"Sarikouch","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jtcvs.2016.04.087","article-title":"A proposal for prospective late outcome analysis of decellularized aortic valves","volume":"152","author":"Bando","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B14","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1161\/CIRCULATIONAHA.110.012161","article-title":"Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: early report","volume":"124","author":"Cebotari","year":"2011","journal-title":"Circulation"},{"key":"2020102110251626400_ezaa100-B15","doi-asserted-by":"crossref","first-page":"e005481","DOI":"10.1161\/CIRCOUTCOMES.118.005481","article-title":"Bioprosthetic aortic valve replacement in nonelderly adults: a systematic review, meta-analysis, microsimulation","volume":"12","author":"Etnel","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2020102110251626400_ezaa100-B16","doi-asserted-by":"crossref","first-page":"e004748","DOI":"10.1161\/CIRCOUTCOMES.118.004748","article-title":"The Ross procedure: a systematic review, meta-analysis, and microsimulation","volume":"11","author":"Etnel","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2020102110251626400_ezaa100-B17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jtcvs.2018.06.037","article-title":"Late results of the Ross procedure","volume":"157","author":"David","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B18","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1161\/CIRCULATIONAHA.115.015939","article-title":"Characteristics and outcomes of patients with severe bioprosthetic aortic valve stenosis undergoing redo surgical aortic valve replacement","volume":"132","author":"Naji","year":"2015","journal-title":"Circulation"},{"key":"2020102110251626400_ezaa100-B19","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.jacc.2018.08.2200","article-title":"Ross procedure in adults for cardiologists and cardiac surgeons: JACC state-of-the-art review","volume":"72","author":"Mazine","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2020102110251626400_ezaa100-B20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0140-6736(10)60828-8","article-title":"Long-term outcomes after autograft versus homograft aortic root replacement in adults with aortic valve disease: a randomised controlled trial","volume":"376","author":"El-Hamamsy","year":"2010","journal-title":"Lancet"},{"key":"2020102110251626400_ezaa100-B21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jtcvs.2018.06.051","article-title":"More data on the Ross procedure","volume":"157","author":"David","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110251626400_ezaa100-B22","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.athoracsur.2014.12.038","article-title":"Outcomes of aortic root replacement after previous aortic root replacement: the \u201ctrue\u201d redo root","volume":"99","author":"Jassar","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2020102110251626400_ezaa100-B23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ejcts.2004.12.057","article-title":"Immunological and echocardiographic evaluation of decellularized versus cryopreserved allografts during the Ross operation","volume":"27","author":"da Costa","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020102110251626400_ezaa100-B24","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.athoracsur.2010.08.022","article-title":"The early and midterm function of decellularized aortic valve allografts","volume":"90","author":"da Costa","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"2020102110251626400_ezaa100-B25","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1089\/ten.tea.2012.0074","article-title":"Orthotopic replacement of aortic heart valves with tissue-engineered grafts","volume":"19","author":"Tudorache","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"2020102110251626400_ezaa100-B26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.athoracsur.2019.02.058","article-title":"Early Insight into In vivo recellularization of cell-free allogenic heart valves","volume":"108","author":"Sarikouch","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2020102110251626400_ezaa100-B27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/ejcts\/ezz054","article-title":"A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data","volume":"56","author":"Boethig","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020102110251626400_ezaa100-B28","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.athoracsur.2018.11.066","article-title":"What is the potential of tissue-engineered pulmonary valves in children?","volume":"107","author":"Huygens","year":"2019","journal-title":"Ann Thorac Surg"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/58\/5\/1045\/33976486\/ezaa100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/58\/5\/1045\/33976486\/ezaa100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T14:25:39Z","timestamp":1603290339000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/58\/5\/1045\/5835338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,9]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,9]]},"published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezaa100","relation":{},"ISSN":["1010-7940","1873-734X"],"issn-type":[{"value":"1010-7940","type":"print"},{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2020,5,9]]}}}