{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:15:55Z","timestamp":1754194555438,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The free margin running suture (FMRS) technique was recently proposed to treat complex degenerative mitral lesions. Limited follow-up data are available. We evaluated the midterm reliability of this technique and the associated mitral valve parameters using rest\/stress echocardiography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>One-hundred-eight consecutive patients at 2 European centres were included. Prospective follow-up was performed (266.1 patient-years, average duration 2.5\u2009\u00b1\u20092.5\u2009years). Echocardiographic scans at rest were obtained for all patients at hospital discharge and at follow-up. Stress echocardiography was also performed in 17 patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There were no operative deaths. FMRS was performed through a right minithoracotomy in 86.1% of patients, with a robotic-assisted technique in 5.6% and through a sternotomy in 8.3%. Bileaflet disease was noted in 31.4%. One patient (0.9%) presented a 2+\/4+ residual mitral regurgitation at discharge; lower-degree or no residual regurgitation was noted in the remaining patients. At the follow-up examination, 1 patient (0.9%) presented with a 2+\/4+ mitral regurgitation. Coaptation length at discharge versus that at follow-up was 1.3\u2009\u00b1\u20090.2 vs 1.3\u2009\u00b1\u20090.1\u2009cm (P\u2009=\u20090.13); the average transmitral gradient was 4.8\u2009\u00b1\u20091.5 vs 3.5\u2009\u00b1\u20090.9\u2009mmHg (P\u2009&amp;lt;\u20090.001). In a subpopulation, follow-up echocardiography indicated that the average transmitral gradient at rest versus that at peak effort was 3.2\u2009\u00b1\u20090.7 vs 5.1\u2009\u00b1\u20091.3\u2009mmHg (P\u2009&amp;lt;\u20090.001), with no appearance of significant mitral regurgitation and marginally significant increases in pulmonary artery systolic pressures (P\u2009=\u20090.049).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Data indicate effectiveness and reproducibility of FMRS, with stability of valve function at midterm. FMRS was also associated with promising outcomes in diastolic performance both at rest and during exercise.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaa122","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T12:51:39Z","timestamp":1584535899000},"page":"847-854","source":"Crossref","is-referenced-by-count":5,"title":["Continued follow-up of the free margin running suture technique for mitral repair"],"prefix":"10.1093","volume":"58","author":[{"given":"Alfonso","family":"Agnino","sequence":"first","affiliation":[{"name":"Division of Minimally Invasive and Video-Assisted Cardiac Surgery, Cliniche Humanitas Gavazzeni, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ascanio","family":"Graniero","sequence":"additional","affiliation":[{"name":"Division of Minimally Invasive and Video-Assisted Cardiac Surgery, Cliniche Humanitas Gavazzeni, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Roscitano","sequence":"additional","affiliation":[{"name":"Division of Cardiac Anesthesia, Cliniche Humanitas Gavazzeni, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Villari","sequence":"additional","affiliation":[{"name":"Division of Cardiac Anesthesia, Cliniche Humanitas Gavazzeni, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Marvelli","sequence":"additional","affiliation":[{"name":"Division of Minimally Invasive and Video-Assisted Cardiac Surgery, Cliniche Humanitas Gavazzeni, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Verhoye","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Pontchaillou University Hospital, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-6644","authenticated-orcid":false,"given":"Amedeo","family":"Anselmi","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Pontchaillou University Hospital, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"2020101419244821400_ezaa122-B1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/ejcts\/ezx324","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"52","author":"Falk","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020101419244821400_ezaa122-B2","doi-asserted-by":"crossref","first-page":"I-8","DOI":"10.1161\/01.CIR.104.suppl_1.I-8","article-title":"Very long-term results (more than 20 years) of valve repair with carpentier\u2019s techniques in 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