{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:25:25Z","timestamp":1774549525279,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p\/><jats:p>Our goal was to report the midterm results of hybrid treatment of extensive thoracic aortic aneurysm (ETAA) with the completion of thoracic endovascular aortic repair after proximal ascending-arch graft replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a multicentre, observational study. Data were collected prospectively between January 2002 and March 2019 and analysed retrospectively. Inclusion criteria for the final analysis were the treatment of elective or urgent ETAA performed in a single-stage or a planned two-stage approach. Early and late survival rates were the primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Indications for repair were degenerative ETAA in 27 (64.3%) patients and dissection-related ETAA in 15 (35.7%). The mean aortic diameter was 68 \u00b1 16\u2009mm (interquartile range 60\u201375). Five (11.9%) patients had a single-stage repair; and 37 underwent a two-stage approach. Three (7.1%) patients died in-hospital. The median follow-up was 49\u2009months (range 0\u2013204). During the follow-up period, 4 (9.5%) patients underwent aortic reintervention after a median of 32\u2009months; however, no aortic rupture of the treated segment occurred. Overall, the estimated survival rate was 85% \u00b1 6% [95% confidence interval (CI) 70.8\u201393] at 12 and 36\u2009months and 69.5% \u00b1 9% (95% CI 49.7\u201384) at 60\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Hybrid repair of ETAA had satisfactory early results in this cohort of patients. At the midterm follow-up, the aneurysm-related mortality rate was acceptable with the reconstruction proving to be durable and safe with few distal aortic events.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejcts\/ezaa178","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T19:21:59Z","timestamp":1589570519000},"page":"940-948","source":"Crossref","is-referenced-by-count":7,"title":["Hybrid repair of extensive thoracic aortic aneurysms"],"prefix":"10.1093","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-4658","authenticated-orcid":false,"given":"Gabriele","family":"Piffaretti","sequence":"first","affiliation":[{"name":"Vascular Surgery, Department of Medicine and Surgery, ASST Settelaghi University Teaching Hospital, University of Insubria School of Medicine, Varese, 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